DEMOGRAPHICS AND CORRELATION OF RISK FACTORS FOR HEPATOCELLULAR CARCINOMA IN PATIENTS PRESENTING TO A TERTIARY CARE FACILITY IN PAKISTAN

Objective: Demographics of HCC in Pakistan. Correlation of HCC with its possible etiology. Correlation of tumor aggressiveness with PCR status and anti-viral treatment. Study Design: Cross sectional study. Place and Duration of Study: Pak Emirates Military Hospital, Rawalpindi from Jul 2017 to...

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Autores principales:	Hafsa Rashid, Laima Alam, Muhammad Asif Farooq, Muhammad Zafar Ali
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	hcv hcc hbv Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/71f0427d049142d9a40e9e18c4ec4719
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spelling	oai:doaj.org-article:71f0427d049142d9a40e9e18c4ec47192021-12-02T16:32:52ZDEMOGRAPHICS AND CORRELATION OF RISK FACTORS FOR HEPATOCELLULAR CARCINOMA IN PATIENTS PRESENTING TO A TERTIARY CARE FACILITY IN PAKISTAN0030-96482411-884210.51253/pafmj.v71i2.2724https://doaj.org/article/71f0427d049142d9a40e9e18c4ec47192021-04-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/2724https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: Demographics of HCC in Pakistan. Correlation of HCC with its possible etiology. Correlation of tumor aggressiveness with PCR status and anti-viral treatment. Study Design: Cross sectional study. Place and Duration of Study: Pak Emirates Military Hospital, Rawalpindi from Jul 2017 to Jun 2018. Methodology: Patients with age >18 years presenting with space occupying lesion(s) of liver were confirmed to be HCC according to standard guidelines. The variables such as age, gender, presence of cirrhosis, etiology of cirrhosis, tumor staging, viral status through PCR study and the treatment offered were documented. Baseline descriptive data was reported as mean with SD for continuous variables. Chi square test was used to compare qualitative data. Results: A total of 195 patients were enrolled for one year. Male population with HCC was in predominance (75.9%). Sixty one percent of the afflicted population was having liver cirrhosis, 34.9% had decompensated cirrhosis and 3.8% had no cirrhosis. HCV accounted for the bulk of patients with cirrhosis (82%) followed by HBV (9.2%), HBV and HCV co-infection (3.1%), NASH and cryptogenic cirrhosis (1.5% each). Majority got diagnosed with triphasic CECT scan Abdomen, only 3.6% needed liver biopsy for diagnosis. Majority (43.6%) belonged to BCLC B. Viral PCR was positive for 58.5% and 73.8% of the patients were treatment naïve. Conclusion: HCC shows highest rates seen in male patients presenting in old age. Gender, classes of cirrhosis, number of lesions, portal vein thrombosis and extrahepatic metastasis correlated with possible risk factors of HCC. Tumor aggressiveness correlated with PCR status..............Hafsa RashidLaima AlamMuhammad Asif FarooqMuhammad Zafar AliArmy Medical College RawalpindiarticlehcvhcchbvMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 2, Pp 614-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hcv hcc hbv Medicine R Medicine (General) R5-920
spellingShingle	hcv hcc hbv Medicine R Medicine (General) R5-920 Hafsa Rashid Laima Alam Muhammad Asif Farooq Muhammad Zafar Ali DEMOGRAPHICS AND CORRELATION OF RISK FACTORS FOR HEPATOCELLULAR CARCINOMA IN PATIENTS PRESENTING TO A TERTIARY CARE FACILITY IN PAKISTAN
description	Objective: Demographics of HCC in Pakistan. Correlation of HCC with its possible etiology. Correlation of tumor aggressiveness with PCR status and anti-viral treatment. Study Design: Cross sectional study. Place and Duration of Study: Pak Emirates Military Hospital, Rawalpindi from Jul 2017 to Jun 2018. Methodology: Patients with age >18 years presenting with space occupying lesion(s) of liver were confirmed to be HCC according to standard guidelines. The variables such as age, gender, presence of cirrhosis, etiology of cirrhosis, tumor staging, viral status through PCR study and the treatment offered were documented. Baseline descriptive data was reported as mean with SD for continuous variables. Chi square test was used to compare qualitative data. Results: A total of 195 patients were enrolled for one year. Male population with HCC was in predominance (75.9%). Sixty one percent of the afflicted population was having liver cirrhosis, 34.9% had decompensated cirrhosis and 3.8% had no cirrhosis. HCV accounted for the bulk of patients with cirrhosis (82%) followed by HBV (9.2%), HBV and HCV co-infection (3.1%), NASH and cryptogenic cirrhosis (1.5% each). Majority got diagnosed with triphasic CECT scan Abdomen, only 3.6% needed liver biopsy for diagnosis. Majority (43.6%) belonged to BCLC B. Viral PCR was positive for 58.5% and 73.8% of the patients were treatment naïve. Conclusion: HCC shows highest rates seen in male patients presenting in old age. Gender, classes of cirrhosis, number of lesions, portal vein thrombosis and extrahepatic metastasis correlated with possible risk factors of HCC. Tumor aggressiveness correlated with PCR status..............
format	article
author	Hafsa Rashid Laima Alam Muhammad Asif Farooq Muhammad Zafar Ali
author_facet	Hafsa Rashid Laima Alam Muhammad Asif Farooq Muhammad Zafar Ali
author_sort	Hafsa Rashid
title	DEMOGRAPHICS AND CORRELATION OF RISK FACTORS FOR HEPATOCELLULAR CARCINOMA IN PATIENTS PRESENTING TO A TERTIARY CARE FACILITY IN PAKISTAN
title_short	DEMOGRAPHICS AND CORRELATION OF RISK FACTORS FOR HEPATOCELLULAR CARCINOMA IN PATIENTS PRESENTING TO A TERTIARY CARE FACILITY IN PAKISTAN
title_full	DEMOGRAPHICS AND CORRELATION OF RISK FACTORS FOR HEPATOCELLULAR CARCINOMA IN PATIENTS PRESENTING TO A TERTIARY CARE FACILITY IN PAKISTAN
title_fullStr	DEMOGRAPHICS AND CORRELATION OF RISK FACTORS FOR HEPATOCELLULAR CARCINOMA IN PATIENTS PRESENTING TO A TERTIARY CARE FACILITY IN PAKISTAN
title_full_unstemmed	DEMOGRAPHICS AND CORRELATION OF RISK FACTORS FOR HEPATOCELLULAR CARCINOMA IN PATIENTS PRESENTING TO A TERTIARY CARE FACILITY IN PAKISTAN
title_sort	demographics and correlation of risk factors for hepatocellular carcinoma in patients presenting to a tertiary care facility in pakistan
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/71f0427d049142d9a40e9e18c4ec4719
work_keys_str_mv	AT hafsarashid demographicsandcorrelationofriskfactorsforhepatocellularcarcinomainpatientspresentingtoatertiarycarefacilityinpakistan AT laimaalam demographicsandcorrelationofriskfactorsforhepatocellularcarcinomainpatientspresentingtoatertiarycarefacilityinpakistan AT muhammadasiffarooq demographicsandcorrelationofriskfactorsforhepatocellularcarcinomainpatientspresentingtoatertiarycarefacilityinpakistan AT muhammadzafarali demographicsandcorrelationofriskfactorsforhepatocellularcarcinomainpatientspresentingtoatertiarycarefacilityinpakistan
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DEMOGRAPHICS AND CORRELATION OF RISK FACTORS FOR HEPATOCELLULAR CARCINOMA IN PATIENTS PRESENTING TO A TERTIARY CARE FACILITY IN PAKISTAN

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