Visualizing conformation transitions of the Lipid II flippase MurJ

MurJ is the flippase for the lipid-linked peptidoglycan precursor Lipid II, a key player in bacterial cell wall synthesis, but the flipping mechanism remains poorly understood. Here authors report crystal structures of MurJ in different conformations which shed light on the MurJ transitions that med...

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Autores principales:	Alvin C. Y. Kuk, Aili Hao, Ziqiang Guan, Seok-Yong Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/71f0ddd37909443ba24e3d041861cfbf
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id	oai:doaj.org-article:71f0ddd37909443ba24e3d041861cfbf
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spelling	oai:doaj.org-article:71f0ddd37909443ba24e3d041861cfbf2021-12-02T16:58:14ZVisualizing conformation transitions of the Lipid II flippase MurJ10.1038/s41467-019-09658-02041-1723https://doaj.org/article/71f0ddd37909443ba24e3d041861cfbf2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09658-0https://doaj.org/toc/2041-1723MurJ is the flippase for the lipid-linked peptidoglycan precursor Lipid II, a key player in bacterial cell wall synthesis, but the flipping mechanism remains poorly understood. Here authors report crystal structures of MurJ in different conformations which shed light on the MurJ transitions that mediate lipid flipping.Alvin C. Y. KukAili HaoZiqiang GuanSeok-Yong LeeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alvin C. Y. Kuk Aili Hao Ziqiang Guan Seok-Yong Lee Visualizing conformation transitions of the Lipid II flippase MurJ
description	MurJ is the flippase for the lipid-linked peptidoglycan precursor Lipid II, a key player in bacterial cell wall synthesis, but the flipping mechanism remains poorly understood. Here authors report crystal structures of MurJ in different conformations which shed light on the MurJ transitions that mediate lipid flipping.
format	article
author	Alvin C. Y. Kuk Aili Hao Ziqiang Guan Seok-Yong Lee
author_facet	Alvin C. Y. Kuk Aili Hao Ziqiang Guan Seok-Yong Lee
author_sort	Alvin C. Y. Kuk
title	Visualizing conformation transitions of the Lipid II flippase MurJ
title_short	Visualizing conformation transitions of the Lipid II flippase MurJ
title_full	Visualizing conformation transitions of the Lipid II flippase MurJ
title_fullStr	Visualizing conformation transitions of the Lipid II flippase MurJ
title_full_unstemmed	Visualizing conformation transitions of the Lipid II flippase MurJ
title_sort	visualizing conformation transitions of the lipid ii flippase murj
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/71f0ddd37909443ba24e3d041861cfbf
work_keys_str_mv	AT alvincykuk visualizingconformationtransitionsofthelipidiiflippasemurj AT ailihao visualizingconformationtransitionsofthelipidiiflippasemurj AT ziqiangguan visualizingconformationtransitionsofthelipidiiflippasemurj AT seokyonglee visualizingconformationtransitionsofthelipidiiflippasemurj
_version_	1718382335298109440

Visualizing conformation transitions of the Lipid II flippase MurJ

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