Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice

Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice

Post-transcriptional modification of RNA can contribute to regulating behavior. Here, the authors show that modulating the expression of Fto results in epitranscriptomic changes in the mouse hippocampus associated with depression-like behavior.

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Autores principales: Shu Liu, Jianbo Xiu, Caiyun Zhu, Kexin Meng, Chen Li, Rongrong Han, Tingfu Du, Lanlan Li, Lingdan Xu, Renjie Liu, Wanwan Zhu, Yan Shen, Qi Xu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/71f4d2ea3f6b44e1a1921e645f08bb41
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spelling oai:doaj.org-article:71f4d2ea3f6b44e1a1921e645f08bb412021-11-28T12:31:35ZFat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice10.1038/s41467-021-27044-72041-1723https://doaj.org/article/71f4d2ea3f6b44e1a1921e645f08bb412021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27044-7https://doaj.org/toc/2041-1723Post-transcriptional modification of RNA can contribute to regulating behavior. Here, the authors show that modulating the expression of Fto results in epitranscriptomic changes in the mouse hippocampus associated with depression-like behavior.Shu LiuJianbo XiuCaiyun ZhuKexin MengChen LiRongrong HanTingfu DuLanlan LiLingdan XuRenjie LiuWanwan ZhuYan ShenQi XuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shu Liu
Jianbo Xiu
Caiyun Zhu
Kexin Meng
Chen Li
Rongrong Han
Tingfu Du
Lanlan Li
Lingdan Xu
Renjie Liu
Wanwan Zhu
Yan Shen
Qi Xu
Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice
description Post-transcriptional modification of RNA can contribute to regulating behavior. Here, the authors show that modulating the expression of Fto results in epitranscriptomic changes in the mouse hippocampus associated with depression-like behavior.
format article
author Shu Liu
Jianbo Xiu
Caiyun Zhu
Kexin Meng
Chen Li
Rongrong Han
Tingfu Du
Lanlan Li
Lingdan Xu
Renjie Liu
Wanwan Zhu
Yan Shen
Qi Xu
author_facet Shu Liu
Jianbo Xiu
Caiyun Zhu
Kexin Meng
Chen Li
Rongrong Han
Tingfu Du
Lanlan Li
Lingdan Xu
Renjie Liu
Wanwan Zhu
Yan Shen
Qi Xu
author_sort Shu Liu
title Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice
title_short Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice
title_full Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice
title_fullStr Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice
title_full_unstemmed Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice
title_sort fat mass and obesity-associated protein regulates rna methylation associated with depression-like behavior in mice
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/71f4d2ea3f6b44e1a1921e645f08bb41
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