OSA treatment history in an upper airway stimulation trial cohort

Objectives: Analyze the obstructive sleep apnea (OSA) treatment history in a group of participants who enrolled in a hypoglossal nerve stimulation trial. Methods: Moderate-severe OSA patients with difficulty adhering to CPAP presented for enrollment in a multicenter trial. Self-reported history on p...

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Autores principales:	Ryan J. Soose, Tapan A. Padhya, M. Boyd Gillespie, Oleg Froymovich, Ho-sheng Lin, B. Tucker Woodson
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2017
Materias:	Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/71f58b933444405993bd18265abab759
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spelling	oai:doaj.org-article:71f58b933444405993bd18265abab7592021-12-02T12:55:56ZOSA treatment history in an upper airway stimulation trial cohort2095-881110.1016/j.wjorl.2017.05.001https://doaj.org/article/71f58b933444405993bd18265abab7592017-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881117300483https://doaj.org/toc/2095-8811Objectives: Analyze the obstructive sleep apnea (OSA) treatment history in a group of participants who enrolled in a hypoglossal nerve stimulation trial. Methods: Moderate-severe OSA patients with difficulty adhering to CPAP presented for enrollment in a multicenter trial. Self-reported history on prior OSA medical therapy was collected at enrollment, including OSA diagnosis date, CPAP start and stop dates, oral appliance trial, and reasons for discontinuation or non-adherence. Results: The cohort consisted of 929 participants, 83% male, with a mean age (53.9 ± 10.5) years. Ninety percent (n = 835) had complete CPAP information including 47% (n = 435) who discontinued therapy prior to enrollment and 43% (n = 400) who were still attempting CPAP but had inadequate adherence. Abandonment rates were 60% at 1-year, 73% at 3-years, and 86% at 5-years. Oral appliance therapy was attempted by 171 patients for mean (1.8 ± 2.3) years, with 81% abandonment at 1 year, 89% at 3-years, and 94% at 5-years. Conclusions: In this CPAP-refractory cohort, high rates of CPAP abandonment were reported in the first several years with approximately half of the participants not receiving any treatment despite being diagnosed for >5 years. Close clinical follow-up and consideration of alternative treatment options is indicated in all OSA patients in order to ensure adequate longitudinal care. Keywords: Upper airway stimulation, Hypoglossal nerve stimulation, STAR trial, Obstructive sleep apnea, CPAP failureRyan J. SooseTapan A. PadhyaM. Boyd GillespieOleg FroymovichHo-sheng LinB. Tucker WoodsonKeAi Communications Co., Ltd.articleOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 3, Iss 2, Pp 79-84 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Otorhinolaryngology RF1-547 Surgery RD1-811 Ryan J. Soose Tapan A. Padhya M. Boyd Gillespie Oleg Froymovich Ho-sheng Lin B. Tucker Woodson OSA treatment history in an upper airway stimulation trial cohort
description	Objectives: Analyze the obstructive sleep apnea (OSA) treatment history in a group of participants who enrolled in a hypoglossal nerve stimulation trial. Methods: Moderate-severe OSA patients with difficulty adhering to CPAP presented for enrollment in a multicenter trial. Self-reported history on prior OSA medical therapy was collected at enrollment, including OSA diagnosis date, CPAP start and stop dates, oral appliance trial, and reasons for discontinuation or non-adherence. Results: The cohort consisted of 929 participants, 83% male, with a mean age (53.9 ± 10.5) years. Ninety percent (n = 835) had complete CPAP information including 47% (n = 435) who discontinued therapy prior to enrollment and 43% (n = 400) who were still attempting CPAP but had inadequate adherence. Abandonment rates were 60% at 1-year, 73% at 3-years, and 86% at 5-years. Oral appliance therapy was attempted by 171 patients for mean (1.8 ± 2.3) years, with 81% abandonment at 1 year, 89% at 3-years, and 94% at 5-years. Conclusions: In this CPAP-refractory cohort, high rates of CPAP abandonment were reported in the first several years with approximately half of the participants not receiving any treatment despite being diagnosed for >5 years. Close clinical follow-up and consideration of alternative treatment options is indicated in all OSA patients in order to ensure adequate longitudinal care. Keywords: Upper airway stimulation, Hypoglossal nerve stimulation, STAR trial, Obstructive sleep apnea, CPAP failure
format	article
author	Ryan J. Soose Tapan A. Padhya M. Boyd Gillespie Oleg Froymovich Ho-sheng Lin B. Tucker Woodson
author_facet	Ryan J. Soose Tapan A. Padhya M. Boyd Gillespie Oleg Froymovich Ho-sheng Lin B. Tucker Woodson
author_sort	Ryan J. Soose
title	OSA treatment history in an upper airway stimulation trial cohort
title_short	OSA treatment history in an upper airway stimulation trial cohort
title_full	OSA treatment history in an upper airway stimulation trial cohort
title_fullStr	OSA treatment history in an upper airway stimulation trial cohort
title_full_unstemmed	OSA treatment history in an upper airway stimulation trial cohort
title_sort	osa treatment history in an upper airway stimulation trial cohort
publisher	KeAi Communications Co., Ltd.
publishDate	2017
url	https://doaj.org/article/71f58b933444405993bd18265abab759
work_keys_str_mv	AT ryanjsoose osatreatmenthistoryinanupperairwaystimulationtrialcohort AT tapanapadhya osatreatmenthistoryinanupperairwaystimulationtrialcohort AT mboydgillespie osatreatmenthistoryinanupperairwaystimulationtrialcohort AT olegfroymovich osatreatmenthistoryinanupperairwaystimulationtrialcohort AT hoshenglin osatreatmenthistoryinanupperairwaystimulationtrialcohort AT btuckerwoodson osatreatmenthistoryinanupperairwaystimulationtrialcohort
_version_	1718393571384492032

OSA treatment history in an upper airway stimulation trial cohort

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