Effects of gallus epidermal growth factor（gEGF）from chicken embryos on growth performance, serum biochemical indices, immune function and intestinal morphology of broilers

We aimed to investigate the effects of dietary supplementation with gallus epidermal growth factor (gEGF) from chicken embryos on growth performance, immunity, and intestinal morphology in broilers. 480 1-day-old AA broilers were randomly divided into 5 groups with 6 replicates of 16 chicks each. Th...

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Autores principales:	Luhong Bai, Xiaoqing Ding, Chuansong Sun, Jianyong Zhou, Jianjun Lu
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	gegf broilers growth performance immunity intestinal morphology Animal culture SF1-1100
Acceso en línea:	https://doaj.org/article/71f70f6e5ebc4beaa04083ef7dd25ffa
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spelling	oai:doaj.org-article:71f70f6e5ebc4beaa04083ef7dd25ffa2021-11-11T14:23:42ZEffects of gallus epidermal growth factor（gEGF）from chicken embryos on growth performance, serum biochemical indices, immune function and intestinal morphology of broilers1594-40771828-051X10.1080/1828051X.2021.1976684https://doaj.org/article/71f70f6e5ebc4beaa04083ef7dd25ffa2021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/1828051X.2021.1976684https://doaj.org/toc/1594-4077https://doaj.org/toc/1828-051XWe aimed to investigate the effects of dietary supplementation with gallus epidermal growth factor (gEGF) from chicken embryos on growth performance, immunity, and intestinal morphology in broilers. 480 1-day-old AA broilers were randomly divided into 5 groups with 6 replicates of 16 chicks each. The control group was fed basal diet and other treatment diets were supplemented with 4, 6, 8, 12 ng/kg gEGF, respectively. The whole experiment lasted for 42 d. Broilers were harvested at the end of the experiment, and spleen, thymus, bursa, serum samples and small intestine were collected. Results showed that average daily growth (ADG) of 1–21d at the 4, 6 and 12 ng/kg groups were significantly increased (p < .05); ADG (22–42d, 1–42d) and ADFI of 1–42d at the 4 ng/kg group were also increased (p < .05). Dietary gEGF at 4 and 6 ng/kg groups improved catalase (CAT) activity, and total antioxidant capacity (T-AOC), glutathione peroxidase (GSH-PX) activity were significantly increased (p < .05) while malondialdehyde (MDA) concentration significantly decreased (p < .05) at 12 ng/kg group. Compared with the control group, the thymus index of the 8 ng/kg group was significantly increased (p < .05). Dietary gEGF at less than or equal to 8 ng/kg level improved Bursa of Fabricius (BF) index (p < .05). Moreover, at the 8 ng/kg group, serum immunoglobulin A (IgA) and immunoglobulin M (IgM) concentrations were significantly higher (p < .05) than in the control group. Intestinal development was enhanced by gEGF inclusion. These findings demonstrated that dietary gEGF supplementation improved growth performance, antioxidant capacity, immunity and the development of the intestine in broilers. And the suitable dosage of gEGF in broiler diets is 8 ng/kg. The gEGF has the potential to be used as a feed additive in broilers.Highlights 4 ng/kg gEGF dietary supplementation had a positive effect (P < 0.05) on growth performance of broilers. Antioxidant capacity (T-AOC, GSH-PX, CAT) of serum significantly increased, and MDA decreased at 12 ng/kg group. Dietary gEGF exhibited positive influence on immunity of broilers. Dietary gEGF improved the development of small intestinal by increasing the villus height and reducing the crypt depth of small intestine in broilers.Luhong BaiXiaoqing DingChuansong SunJianyong ZhouJianjun LuTaylor & Francis Grouparticlegegfbroilersgrowth performanceimmunityintestinal morphologyAnimal cultureSF1-1100ENItalian Journal of Animal Science, Vol 20, Iss 1, Pp 1645-1655 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gegf broilers growth performance immunity intestinal morphology Animal culture SF1-1100
spellingShingle	gegf broilers growth performance immunity intestinal morphology Animal culture SF1-1100 Luhong Bai Xiaoqing Ding Chuansong Sun Jianyong Zhou Jianjun Lu Effects of gallus epidermal growth factor（gEGF）from chicken embryos on growth performance, serum biochemical indices, immune function and intestinal morphology of broilers
description	We aimed to investigate the effects of dietary supplementation with gallus epidermal growth factor (gEGF) from chicken embryos on growth performance, immunity, and intestinal morphology in broilers. 480 1-day-old AA broilers were randomly divided into 5 groups with 6 replicates of 16 chicks each. The control group was fed basal diet and other treatment diets were supplemented with 4, 6, 8, 12 ng/kg gEGF, respectively. The whole experiment lasted for 42 d. Broilers were harvested at the end of the experiment, and spleen, thymus, bursa, serum samples and small intestine were collected. Results showed that average daily growth (ADG) of 1–21d at the 4, 6 and 12 ng/kg groups were significantly increased (p < .05); ADG (22–42d, 1–42d) and ADFI of 1–42d at the 4 ng/kg group were also increased (p < .05). Dietary gEGF at 4 and 6 ng/kg groups improved catalase (CAT) activity, and total antioxidant capacity (T-AOC), glutathione peroxidase (GSH-PX) activity were significantly increased (p < .05) while malondialdehyde (MDA) concentration significantly decreased (p < .05) at 12 ng/kg group. Compared with the control group, the thymus index of the 8 ng/kg group was significantly increased (p < .05). Dietary gEGF at less than or equal to 8 ng/kg level improved Bursa of Fabricius (BF) index (p < .05). Moreover, at the 8 ng/kg group, serum immunoglobulin A (IgA) and immunoglobulin M (IgM) concentrations were significantly higher (p < .05) than in the control group. Intestinal development was enhanced by gEGF inclusion. These findings demonstrated that dietary gEGF supplementation improved growth performance, antioxidant capacity, immunity and the development of the intestine in broilers. And the suitable dosage of gEGF in broiler diets is 8 ng/kg. The gEGF has the potential to be used as a feed additive in broilers.Highlights 4 ng/kg gEGF dietary supplementation had a positive effect (P < 0.05) on growth performance of broilers. Antioxidant capacity (T-AOC, GSH-PX, CAT) of serum significantly increased, and MDA decreased at 12 ng/kg group. Dietary gEGF exhibited positive influence on immunity of broilers. Dietary gEGF improved the development of small intestinal by increasing the villus height and reducing the crypt depth of small intestine in broilers.
format	article
author	Luhong Bai Xiaoqing Ding Chuansong Sun Jianyong Zhou Jianjun Lu
author_facet	Luhong Bai Xiaoqing Ding Chuansong Sun Jianyong Zhou Jianjun Lu
author_sort	Luhong Bai
title	Effects of gallus epidermal growth factor（gEGF）from chicken embryos on growth performance, serum biochemical indices, immune function and intestinal morphology of broilers
title_short	Effects of gallus epidermal growth factor（gEGF）from chicken embryos on growth performance, serum biochemical indices, immune function and intestinal morphology of broilers
title_full	Effects of gallus epidermal growth factor（gEGF）from chicken embryos on growth performance, serum biochemical indices, immune function and intestinal morphology of broilers
title_fullStr	Effects of gallus epidermal growth factor（gEGF）from chicken embryos on growth performance, serum biochemical indices, immune function and intestinal morphology of broilers
title_full_unstemmed	Effects of gallus epidermal growth factor（gEGF）from chicken embryos on growth performance, serum biochemical indices, immune function and intestinal morphology of broilers
title_sort	effects of gallus epidermal growth factor（gegf）from chicken embryos on growth performance, serum biochemical indices, immune function and intestinal morphology of broilers
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/71f70f6e5ebc4beaa04083ef7dd25ffa
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_version_	1718438944790544384

Effects of gallus epidermal growth factor（gEGF）from chicken embryos on growth performance, serum biochemical indices, immune function and intestinal morphology of broilers

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