Novel nanotech antioxidant cocktail prevents medical diagnostic procedures ionizing radiation effects

Abstract Ionizing radiation (IR) exposure results in oxidative damage causing cytotoxic and genotoxic effects. Double-strand breaks (DSBs) are considered the most significant DNA lesions induced by ionizing radiation. The present study evaluates the radio protective effect of a novel antioxidant coc...

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Autores principales:	Miguel Gorenberg, Abed Agbarya, David Groshar, Ilya Volovik, Ofir Avitan, Igor Sukhotnik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/71f8f1a4967e4bb6b8dcbeb39fc1804c
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spelling	oai:doaj.org-article:71f8f1a4967e4bb6b8dcbeb39fc1804c2021-12-02T13:30:50ZNovel nanotech antioxidant cocktail prevents medical diagnostic procedures ionizing radiation effects10.1038/s41598-021-84596-w2045-2322https://doaj.org/article/71f8f1a4967e4bb6b8dcbeb39fc1804c2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84596-whttps://doaj.org/toc/2045-2322Abstract Ionizing radiation (IR) exposure results in oxidative damage causing cytotoxic and genotoxic effects. Double-strand breaks (DSBs) are considered the most significant DNA lesions induced by ionizing radiation. The present study evaluates the radio protective effect of a novel antioxidant cocktail through quantification of DSB in peripheral blood lymphocytes (PBL) in vivo. The study included 16 consecutive patients who were divided into 2 groups, 6 patients received the novel antioxidant cocktail and 10 control patients. Blood samples were drawn from the patients undergoing bone scan, before the injection of the 99mTc MDP tracer and 2 h after the injection. Quantification of the IR damage was done by Immunofluorescence analysis of the phosphorylated histone, γ-H2AX, used to monitor DSB induction and repair in PBL. The radiation effect of the control group was measured by 2 variables, the average DBSs foci per nucleus and the percent of the DSB bearing cells in PBL. The findings showed a significant increase in the DSBs after isotope injection with an average increment of 0.29 ± 0.13 of foci/nucleus and 17.07% ± 7.68 more DSB bearing cells (p < 0.05). The cocktail treated group showed a lower difference average of − 2.79% ± 6.13 DSB bearing cells. A paired t-test revealed a significant difference between the groups (p < 0.005) confirming the cocktail’s protective effect. The novel anti-oxidant treatment decreases the oxidative stress-induced DNA damage and can be considered as a preventative treatment before radiation exposure.Miguel GorenbergAbed AgbaryaDavid GrosharIlya VolovikOfir AvitanIgor SukhotnikNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Miguel Gorenberg Abed Agbarya David Groshar Ilya Volovik Ofir Avitan Igor Sukhotnik Novel nanotech antioxidant cocktail prevents medical diagnostic procedures ionizing radiation effects
description	Abstract Ionizing radiation (IR) exposure results in oxidative damage causing cytotoxic and genotoxic effects. Double-strand breaks (DSBs) are considered the most significant DNA lesions induced by ionizing radiation. The present study evaluates the radio protective effect of a novel antioxidant cocktail through quantification of DSB in peripheral blood lymphocytes (PBL) in vivo. The study included 16 consecutive patients who were divided into 2 groups, 6 patients received the novel antioxidant cocktail and 10 control patients. Blood samples were drawn from the patients undergoing bone scan, before the injection of the 99mTc MDP tracer and 2 h after the injection. Quantification of the IR damage was done by Immunofluorescence analysis of the phosphorylated histone, γ-H2AX, used to monitor DSB induction and repair in PBL. The radiation effect of the control group was measured by 2 variables, the average DBSs foci per nucleus and the percent of the DSB bearing cells in PBL. The findings showed a significant increase in the DSBs after isotope injection with an average increment of 0.29 ± 0.13 of foci/nucleus and 17.07% ± 7.68 more DSB bearing cells (p < 0.05). The cocktail treated group showed a lower difference average of − 2.79% ± 6.13 DSB bearing cells. A paired t-test revealed a significant difference between the groups (p < 0.005) confirming the cocktail’s protective effect. The novel anti-oxidant treatment decreases the oxidative stress-induced DNA damage and can be considered as a preventative treatment before radiation exposure.
format	article
author	Miguel Gorenberg Abed Agbarya David Groshar Ilya Volovik Ofir Avitan Igor Sukhotnik
author_facet	Miguel Gorenberg Abed Agbarya David Groshar Ilya Volovik Ofir Avitan Igor Sukhotnik
author_sort	Miguel Gorenberg
title	Novel nanotech antioxidant cocktail prevents medical diagnostic procedures ionizing radiation effects
title_short	Novel nanotech antioxidant cocktail prevents medical diagnostic procedures ionizing radiation effects
title_full	Novel nanotech antioxidant cocktail prevents medical diagnostic procedures ionizing radiation effects
title_fullStr	Novel nanotech antioxidant cocktail prevents medical diagnostic procedures ionizing radiation effects
title_full_unstemmed	Novel nanotech antioxidant cocktail prevents medical diagnostic procedures ionizing radiation effects
title_sort	novel nanotech antioxidant cocktail prevents medical diagnostic procedures ionizing radiation effects
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/71f8f1a4967e4bb6b8dcbeb39fc1804c
work_keys_str_mv	AT miguelgorenberg novelnanotechantioxidantcocktailpreventsmedicaldiagnosticproceduresionizingradiationeffects AT abedagbarya novelnanotechantioxidantcocktailpreventsmedicaldiagnosticproceduresionizingradiationeffects AT davidgroshar novelnanotechantioxidantcocktailpreventsmedicaldiagnosticproceduresionizingradiationeffects AT ilyavolovik novelnanotechantioxidantcocktailpreventsmedicaldiagnosticproceduresionizingradiationeffects AT ofiravitan novelnanotechantioxidantcocktailpreventsmedicaldiagnosticproceduresionizingradiationeffects AT igorsukhotnik novelnanotechantioxidantcocktailpreventsmedicaldiagnosticproceduresionizingradiationeffects
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Novel nanotech antioxidant cocktail prevents medical diagnostic procedures ionizing radiation effects

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