Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4

The RNAse III endonuclease Dicer is crucial for processing of pre-miRNAs in health and disease. Here the authors show that endothelial Dicer promotes atherosclerosis by increasing miR-103 levels leading to suppression of the anti-inflammatory transcription factor KLF4, thus suggesting a novel approa...

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Autores principales:	Petra Hartmann, Zhe Zhou, Lucia Natarelli, Yuanyuan Wei, Maliheh Nazari-Jahantigh, Mengyu Zhu, Jochen Grommes, Sabine Steffens, Christian Weber, Andreas Schober
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/72009970f9fa4165be7c03cb3838e159
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spelling	oai:doaj.org-article:72009970f9fa4165be7c03cb3838e1592021-12-02T16:58:23ZEndothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF410.1038/ncomms105212041-1723https://doaj.org/article/72009970f9fa4165be7c03cb3838e1592016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10521https://doaj.org/toc/2041-1723The RNAse III endonuclease Dicer is crucial for processing of pre-miRNAs in health and disease. Here the authors show that endothelial Dicer promotes atherosclerosis by increasing miR-103 levels leading to suppression of the anti-inflammatory transcription factor KLF4, thus suggesting a novel approach to treat this disease.Petra HartmannZhe ZhouLucia NatarelliYuanyuan WeiMaliheh Nazari-JahantighMengyu ZhuJochen GrommesSabine SteffensChristian WeberAndreas SchoberNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Petra Hartmann Zhe Zhou Lucia Natarelli Yuanyuan Wei Maliheh Nazari-Jahantigh Mengyu Zhu Jochen Grommes Sabine Steffens Christian Weber Andreas Schober Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4
description	The RNAse III endonuclease Dicer is crucial for processing of pre-miRNAs in health and disease. Here the authors show that endothelial Dicer promotes atherosclerosis by increasing miR-103 levels leading to suppression of the anti-inflammatory transcription factor KLF4, thus suggesting a novel approach to treat this disease.
format	article
author	Petra Hartmann Zhe Zhou Lucia Natarelli Yuanyuan Wei Maliheh Nazari-Jahantigh Mengyu Zhu Jochen Grommes Sabine Steffens Christian Weber Andreas Schober
author_facet	Petra Hartmann Zhe Zhou Lucia Natarelli Yuanyuan Wei Maliheh Nazari-Jahantigh Mengyu Zhu Jochen Grommes Sabine Steffens Christian Weber Andreas Schober
author_sort	Petra Hartmann
title	Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4
title_short	Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4
title_full	Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4
title_fullStr	Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4
title_full_unstemmed	Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4
title_sort	endothelial dicer promotes atherosclerosis and vascular inflammation by mirna-103-mediated suppression of klf4
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/72009970f9fa4165be7c03cb3838e159
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Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4

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