Endogenous Oxytocin Levels in Autism—A Meta-Analysis

Oxytocin (OT) circuitry plays a major role in the mediation of prosocial behavior. Individuals with autism spectrum disorder (ASD) are characterized by impairments in social interaction and communication and have been suggested to display deficiencies in central OT mechanisms. The current preregiste...

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Autores principales:	Matthijs Moerkerke, Mathieu Peeters, Lyssa de Vries, Nicky Daniels, Jean Steyaert, Kaat Alaerts, Bart Boets
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	endogenous oxytocin autism spectrum disorder biological marker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/72022981ce014a298f6f2d02cdf3360d
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spelling	oai:doaj.org-article:72022981ce014a298f6f2d02cdf3360d2021-11-25T16:59:22ZEndogenous Oxytocin Levels in Autism—A Meta-Analysis10.3390/brainsci111115452076-3425https://doaj.org/article/72022981ce014a298f6f2d02cdf3360d2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1545https://doaj.org/toc/2076-3425Oxytocin (OT) circuitry plays a major role in the mediation of prosocial behavior. Individuals with autism spectrum disorder (ASD) are characterized by impairments in social interaction and communication and have been suggested to display deficiencies in central OT mechanisms. The current preregistered meta-analysis evaluated potential group differences in endogenous OT levels between individuals with ASD and neurotypical (NT) controls. We included 18 studies comprising a total of 1422 participants. We found that endogenous OT levels are lower in children with ASD as compared to NT controls (n = 1123; g = −0.60; <i>p</i> = 0.006), but this effect seems to disappear in adolescent (n = 152; g = −0.20; <i>p</i> = 0.53) and adult populations (n = 147; g = 0.27; <i>p</i> = 0.45). Secondly, while no significant subgroup differences were found in regard to sex, the group difference in OT levels of individuals with versus without ASD seems to be only present in the studies with male participants (n = 814; g = −0.44; <i>p</i> = 0.08) and not female participants (n = 192; g = 0.11; <i>p</i> = 0.47). More research that employs more homogeneous methods is necessary to investigate potential developmental changes in endogenous OT levels, both in typical and atypical development, and to explore the possible use of OT level measurement as a diagnostic marker of ASD.Matthijs MoerkerkeMathieu PeetersLyssa de VriesNicky DanielsJean SteyaertKaat AlaertsBart BoetsMDPI AGarticleendogenous oxytocinautism spectrum disorderbiological markerNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1545, p 1545 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	endogenous oxytocin autism spectrum disorder biological marker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	endogenous oxytocin autism spectrum disorder biological marker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Matthijs Moerkerke Mathieu Peeters Lyssa de Vries Nicky Daniels Jean Steyaert Kaat Alaerts Bart Boets Endogenous Oxytocin Levels in Autism—A Meta-Analysis
description	Oxytocin (OT) circuitry plays a major role in the mediation of prosocial behavior. Individuals with autism spectrum disorder (ASD) are characterized by impairments in social interaction and communication and have been suggested to display deficiencies in central OT mechanisms. The current preregistered meta-analysis evaluated potential group differences in endogenous OT levels between individuals with ASD and neurotypical (NT) controls. We included 18 studies comprising a total of 1422 participants. We found that endogenous OT levels are lower in children with ASD as compared to NT controls (n = 1123; g = −0.60; <i>p</i> = 0.006), but this effect seems to disappear in adolescent (n = 152; g = −0.20; <i>p</i> = 0.53) and adult populations (n = 147; g = 0.27; <i>p</i> = 0.45). Secondly, while no significant subgroup differences were found in regard to sex, the group difference in OT levels of individuals with versus without ASD seems to be only present in the studies with male participants (n = 814; g = −0.44; <i>p</i> = 0.08) and not female participants (n = 192; g = 0.11; <i>p</i> = 0.47). More research that employs more homogeneous methods is necessary to investigate potential developmental changes in endogenous OT levels, both in typical and atypical development, and to explore the possible use of OT level measurement as a diagnostic marker of ASD.
format	article
author	Matthijs Moerkerke Mathieu Peeters Lyssa de Vries Nicky Daniels Jean Steyaert Kaat Alaerts Bart Boets
author_facet	Matthijs Moerkerke Mathieu Peeters Lyssa de Vries Nicky Daniels Jean Steyaert Kaat Alaerts Bart Boets
author_sort	Matthijs Moerkerke
title	Endogenous Oxytocin Levels in Autism—A Meta-Analysis
title_short	Endogenous Oxytocin Levels in Autism—A Meta-Analysis
title_full	Endogenous Oxytocin Levels in Autism—A Meta-Analysis
title_fullStr	Endogenous Oxytocin Levels in Autism—A Meta-Analysis
title_full_unstemmed	Endogenous Oxytocin Levels in Autism—A Meta-Analysis
title_sort	endogenous oxytocin levels in autism—a meta-analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/72022981ce014a298f6f2d02cdf3360d
work_keys_str_mv	AT matthijsmoerkerke endogenousoxytocinlevelsinautismametaanalysis AT mathieupeeters endogenousoxytocinlevelsinautismametaanalysis AT lyssadevries endogenousoxytocinlevelsinautismametaanalysis AT nickydaniels endogenousoxytocinlevelsinautismametaanalysis AT jeansteyaert endogenousoxytocinlevelsinautismametaanalysis AT kaatalaerts endogenousoxytocinlevelsinautismametaanalysis AT bartboets endogenousoxytocinlevelsinautismametaanalysis
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Endogenous Oxytocin Levels in Autism—A Meta-Analysis

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