Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes

Triple-negative breast cancers (TNBC) have enhanced migratory behaviour. Here, the authors perform a phenotypic imaging-based RNAi screen to identify several genes associated with regulation of migratory phenotypes and show that one of the regulators, PRPF4B, mediates metastasis in TNBC in mice.

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Detalles Bibliográficos
Autores principales:	Esmee Koedoot, Michiel Fokkelman, Vasiliki-Maria Rogkoti, Marcel Smid, Iris van de Sandt, Hans de Bont, Chantal Pont, Janna E. Klip, Steven Wink, Mieke A. Timmermans, Erik A. C. Wiemer, Peter Stoilov, John A. Foekens, Sylvia E. Le Dévédec, John W. M. Martens, Bob van de Water
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/720606fcf5f54cc0ae38a7db6f491bec
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spelling	oai:doaj.org-article:720606fcf5f54cc0ae38a7db6f491bec2021-12-02T14:35:30ZUncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes10.1038/s41467-019-11020-32041-1723https://doaj.org/article/720606fcf5f54cc0ae38a7db6f491bec2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11020-3https://doaj.org/toc/2041-1723Triple-negative breast cancers (TNBC) have enhanced migratory behaviour. Here, the authors perform a phenotypic imaging-based RNAi screen to identify several genes associated with regulation of migratory phenotypes and show that one of the regulators, PRPF4B, mediates metastasis in TNBC in mice.Esmee KoedootMichiel FokkelmanVasiliki-Maria RogkotiMarcel SmidIris van de SandtHans de BontChantal PontJanna E. KlipSteven WinkMieke A. TimmermansErik A. C. WiemerPeter StoilovJohn A. FoekensSylvia E. Le DévédecJohn W. M. MartensBob van de WaterNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Esmee Koedoot Michiel Fokkelman Vasiliki-Maria Rogkoti Marcel Smid Iris van de Sandt Hans de Bont Chantal Pont Janna E. Klip Steven Wink Mieke A. Timmermans Erik A. C. Wiemer Peter Stoilov John A. Foekens Sylvia E. Le Dévédec John W. M. Martens Bob van de Water Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes
description	Triple-negative breast cancers (TNBC) have enhanced migratory behaviour. Here, the authors perform a phenotypic imaging-based RNAi screen to identify several genes associated with regulation of migratory phenotypes and show that one of the regulators, PRPF4B, mediates metastasis in TNBC in mice.
format	article
author	Esmee Koedoot Michiel Fokkelman Vasiliki-Maria Rogkoti Marcel Smid Iris van de Sandt Hans de Bont Chantal Pont Janna E. Klip Steven Wink Mieke A. Timmermans Erik A. C. Wiemer Peter Stoilov John A. Foekens Sylvia E. Le Dévédec John W. M. Martens Bob van de Water
author_facet	Esmee Koedoot Michiel Fokkelman Vasiliki-Maria Rogkoti Marcel Smid Iris van de Sandt Hans de Bont Chantal Pont Janna E. Klip Steven Wink Mieke A. Timmermans Erik A. C. Wiemer Peter Stoilov John A. Foekens Sylvia E. Le Dévédec John W. M. Martens Bob van de Water
author_sort	Esmee Koedoot
title	Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes
title_short	Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes
title_full	Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes
title_fullStr	Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes
title_full_unstemmed	Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes
title_sort	uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/720606fcf5f54cc0ae38a7db6f491bec
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Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes

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