Treatment of neurological complications in patients with type 2 diabetes mellitus at the stage of rehabilitation after COVID-19

Although the predominant clinical manifestation of COVID-19 is a respiratory disease, various neurological symptoms are increasingly being diagnosed, in particular, diabetic polyneuropathy is diagnosed in most patients with diabetes, affecting large and small nerve fibers. Drugs that are traditional...

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Autor principal:	V.I. Pankiv
Formato:	article
Lenguaje:	EN RU UK
Publicado:	Publishing House Zaslavsky 2021
Materias:	diabetes mellitus, neuropathies, rehabilitation, covid-19 Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/720772e7e2394961a8e894e208adf48a
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spelling	oai:doaj.org-article:720772e7e2394961a8e894e208adf48a2021-11-22T11:26:20ZTreatment of neurological complications in patients with type 2 diabetes mellitus at the stage of rehabilitation after COVID-192224-07212307-142710.22141/2224-0721.17.6.2021.243214https://doaj.org/article/720772e7e2394961a8e894e208adf48a2021-10-01T00:00:00Zhttp://iej.zaslavsky.com.ua/article/view/243214https://doaj.org/toc/2224-0721https://doaj.org/toc/2307-1427Although the predominant clinical manifestation of COVID-19 is a respiratory disease, various neurological symptoms are increasingly being diagnosed, in particular, diabetic polyneuropathy is diagnosed in most patients with diabetes, affecting large and small nerve fibers. Drugs that are traditionally used for neuropathic pain (tricyclic antidepressants, gabapentinoids, etc.), despite their positive effect in eliminating the symptoms of polyneuropathy, often cause side effects and do not impact nerve regeneration. Over the last decade, a group of nucleotides has been used quite actively. Additional information on the effects of this group of drugs was accumulated and there is a gradual transformation, including their compositions. Thus, recently the attention of researchers has been devoted to the study of the effectiveness of the combination of uridine, choline, vitamins B1, B6, B12, and folic acid, which is characterized by a fairly high safety profile and regenerative potential. The review highlights the mechanisms of action and results of clinical use of this combination. Uridine monophosphate, B vitamins, folic acid are involved in metabolic processes, enhancing nerve regeneration. This contributes to the development of indirect (secondary) analgesic effect. In addition, the data of new studies indicate the ability of uridine monophosphate derivatives to impact purinergic P2Y receptors, which causes a direct analgesic and direct regenerative effect. Studies have demonstrated the clinical efficacy of this combination in the main types of peripheral neuropathic pain. The combination did not cause side effects and was well tolerated. There was a reduction or complete withdrawal of concomitant analgesics against the background of improving the quality of life of patients. The combination of uridine, choline, vitamin B1, vitamin B6, vitamin B12, and folic acid is a very effective addition to the standard therapy of peripheral neuropathic pain of various genesis and rehabilitation after COVID-19.V.I. PankivPublishing House Zaslavskyarticlediabetes mellitus, neuropathies, rehabilitation, covid-19Diseases of the endocrine glands. Clinical endocrinologyRC648-665ENRUUKMìžnarodnij Endokrinologìčnij Žurnal, Vol 17, Iss 6, Pp 491-495 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU UK
topic	diabetes mellitus, neuropathies, rehabilitation, covid-19 Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	diabetes mellitus, neuropathies, rehabilitation, covid-19 Diseases of the endocrine glands. Clinical endocrinology RC648-665 V.I. Pankiv Treatment of neurological complications in patients with type 2 diabetes mellitus at the stage of rehabilitation after COVID-19
description	Although the predominant clinical manifestation of COVID-19 is a respiratory disease, various neurological symptoms are increasingly being diagnosed, in particular, diabetic polyneuropathy is diagnosed in most patients with diabetes, affecting large and small nerve fibers. Drugs that are traditionally used for neuropathic pain (tricyclic antidepressants, gabapentinoids, etc.), despite their positive effect in eliminating the symptoms of polyneuropathy, often cause side effects and do not impact nerve regeneration. Over the last decade, a group of nucleotides has been used quite actively. Additional information on the effects of this group of drugs was accumulated and there is a gradual transformation, including their compositions. Thus, recently the attention of researchers has been devoted to the study of the effectiveness of the combination of uridine, choline, vitamins B1, B6, B12, and folic acid, which is characterized by a fairly high safety profile and regenerative potential. The review highlights the mechanisms of action and results of clinical use of this combination. Uridine monophosphate, B vitamins, folic acid are involved in metabolic processes, enhancing nerve regeneration. This contributes to the development of indirect (secondary) analgesic effect. In addition, the data of new studies indicate the ability of uridine monophosphate derivatives to impact purinergic P2Y receptors, which causes a direct analgesic and direct regenerative effect. Studies have demonstrated the clinical efficacy of this combination in the main types of peripheral neuropathic pain. The combination did not cause side effects and was well tolerated. There was a reduction or complete withdrawal of concomitant analgesics against the background of improving the quality of life of patients. The combination of uridine, choline, vitamin B1, vitamin B6, vitamin B12, and folic acid is a very effective addition to the standard therapy of peripheral neuropathic pain of various genesis and rehabilitation after COVID-19.
format	article
author	V.I. Pankiv
author_facet	V.I. Pankiv
author_sort	V.I. Pankiv
title	Treatment of neurological complications in patients with type 2 diabetes mellitus at the stage of rehabilitation after COVID-19
title_short	Treatment of neurological complications in patients with type 2 diabetes mellitus at the stage of rehabilitation after COVID-19
title_full	Treatment of neurological complications in patients with type 2 diabetes mellitus at the stage of rehabilitation after COVID-19
title_fullStr	Treatment of neurological complications in patients with type 2 diabetes mellitus at the stage of rehabilitation after COVID-19
title_full_unstemmed	Treatment of neurological complications in patients with type 2 diabetes mellitus at the stage of rehabilitation after COVID-19
title_sort	treatment of neurological complications in patients with type 2 diabetes mellitus at the stage of rehabilitation after covid-19
publisher	Publishing House Zaslavsky
publishDate	2021
url	https://doaj.org/article/720772e7e2394961a8e894e208adf48a
work_keys_str_mv	AT vipankiv treatmentofneurologicalcomplicationsinpatientswithtype2diabetesmellitusatthestageofrehabilitationaftercovid19
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Treatment of neurological complications in patients with type 2 diabetes mellitus at the stage of rehabilitation after COVID-19

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