Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites

Microbial DNA glycosylases associated with the biosynthesis of DNA-damaging antibiotics have evolved self-resistance for their cognate natural products. Here, the authors provide evidence that cellular self-resistance is enabled by reduced affinity of the glycosylases for the excision products of th...

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Autores principales:	Elwood A. Mullins, Jonathan Dorival, Gong-Li Tang, Dale L. Boger, Brandt F. Eichman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/720d0a38f220438cbce58c8a50392b7b
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spelling	oai:doaj.org-article:720d0a38f220438cbce58c8a50392b7b2021-11-28T12:31:29ZStructural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites10.1038/s41467-021-27284-72041-1723https://doaj.org/article/720d0a38f220438cbce58c8a50392b7b2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27284-7https://doaj.org/toc/2041-1723Microbial DNA glycosylases associated with the biosynthesis of DNA-damaging antibiotics have evolved self-resistance for their cognate natural products. Here, the authors provide evidence that cellular self-resistance is enabled by reduced affinity of the glycosylases for the excision products of the corresponding DNA lesions.Elwood A. MullinsJonathan DorivalGong-Li TangDale L. BogerBrandt F. EichmanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elwood A. Mullins Jonathan Dorival Gong-Li Tang Dale L. Boger Brandt F. Eichman Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites
description	Microbial DNA glycosylases associated with the biosynthesis of DNA-damaging antibiotics have evolved self-resistance for their cognate natural products. Here, the authors provide evidence that cellular self-resistance is enabled by reduced affinity of the glycosylases for the excision products of the corresponding DNA lesions.
format	article
author	Elwood A. Mullins Jonathan Dorival Gong-Li Tang Dale L. Boger Brandt F. Eichman
author_facet	Elwood A. Mullins Jonathan Dorival Gong-Li Tang Dale L. Boger Brandt F. Eichman
author_sort	Elwood A. Mullins
title	Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites
title_short	Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites
title_full	Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites
title_fullStr	Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites
title_full_unstemmed	Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites
title_sort	structural evolution of a dna repair self-resistance mechanism targeting genotoxic secondary metabolites
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/720d0a38f220438cbce58c8a50392b7b
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Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites

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