Chlamydia pneumoniae-specific IgE is prevalent in asthma and is associated with disease severity.

<h4>Background</h4>Several Chlamydia pneumoniae (Cp) biomarkers have been associated with asthma but Cp-specific IgE (Cp IgE) has not been investigated extensively. Our objective was to investigate Cp IgE in community adult asthma patients.<h4>Methods</h4>(1) Prevalence of Cp...

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Autores principales:	David L Hahn, Allison Schure, Katir Patel, Tawanna Childs, Eduard Drizik, Wilmore Webley
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7210eaf058d44e42b1c01a06f2bc703f
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spelling	oai:doaj.org-article:7210eaf058d44e42b1c01a06f2bc703f2021-11-18T07:21:05ZChlamydia pneumoniae-specific IgE is prevalent in asthma and is associated with disease severity.1932-620310.1371/journal.pone.0035945https://doaj.org/article/7210eaf058d44e42b1c01a06f2bc703f2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22545149/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Several Chlamydia pneumoniae (Cp) biomarkers have been associated with asthma but Cp-specific IgE (Cp IgE) has not been investigated extensively. Our objective was to investigate Cp IgE in community adult asthma patients.<h4>Methods</h4>(1) Prevalence of Cp IgE (measured by immunoblotting) and Cp DNA (by polymerase chain reaction) in peripheral blood, and biomarker associations with asthma severity. (2) Case-control studies of Cp IgE association with asthma using healthy blood donor (study 1) and non-asthmatic clinic patient (study 2) controls.<h4>Results</h4>Of 66 asthma subjects (mean age 40.9 years, range 5-75, 59% male, 45% ever-smokers) 33 (50%) were Cp IgE positive and 16 (24%) were Cp DNA positive (P = 0.001 for association of Cp IgE and DNA). Cp IgE was detected in 21% of mild intermittent asthma v 79% of severe persistent asthma (test for trend over severity categories, P = 0.002). Cp IgE detection was significantly (P = 0.001) associated with asthma when compared to healthy blood donor controls but not when compared to clinic controls.<h4>Conclusions</h4>Half of this sample of community asthma patients had detectable IgE against C. pneumoniae. Cp IgE was strongly and positively associated with asthma severity and with asthma when healthy blood donor controls were used. These results support the inclusion of Cp IgE as a biomarker in future studies of infectious contributions to asthma pathogenesis.David L HahnAllison SchureKatir PatelTawanna ChildsEduard DrizikWilmore WebleyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e35945 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q David L Hahn Allison Schure Katir Patel Tawanna Childs Eduard Drizik Wilmore Webley Chlamydia pneumoniae-specific IgE is prevalent in asthma and is associated with disease severity.
description	<h4>Background</h4>Several Chlamydia pneumoniae (Cp) biomarkers have been associated with asthma but Cp-specific IgE (Cp IgE) has not been investigated extensively. Our objective was to investigate Cp IgE in community adult asthma patients.<h4>Methods</h4>(1) Prevalence of Cp IgE (measured by immunoblotting) and Cp DNA (by polymerase chain reaction) in peripheral blood, and biomarker associations with asthma severity. (2) Case-control studies of Cp IgE association with asthma using healthy blood donor (study 1) and non-asthmatic clinic patient (study 2) controls.<h4>Results</h4>Of 66 asthma subjects (mean age 40.9 years, range 5-75, 59% male, 45% ever-smokers) 33 (50%) were Cp IgE positive and 16 (24%) were Cp DNA positive (P = 0.001 for association of Cp IgE and DNA). Cp IgE was detected in 21% of mild intermittent asthma v 79% of severe persistent asthma (test for trend over severity categories, P = 0.002). Cp IgE detection was significantly (P = 0.001) associated with asthma when compared to healthy blood donor controls but not when compared to clinic controls.<h4>Conclusions</h4>Half of this sample of community asthma patients had detectable IgE against C. pneumoniae. Cp IgE was strongly and positively associated with asthma severity and with asthma when healthy blood donor controls were used. These results support the inclusion of Cp IgE as a biomarker in future studies of infectious contributions to asthma pathogenesis.
format	article
author	David L Hahn Allison Schure Katir Patel Tawanna Childs Eduard Drizik Wilmore Webley
author_facet	David L Hahn Allison Schure Katir Patel Tawanna Childs Eduard Drizik Wilmore Webley
author_sort	David L Hahn
title	Chlamydia pneumoniae-specific IgE is prevalent in asthma and is associated with disease severity.
title_short	Chlamydia pneumoniae-specific IgE is prevalent in asthma and is associated with disease severity.
title_full	Chlamydia pneumoniae-specific IgE is prevalent in asthma and is associated with disease severity.
title_fullStr	Chlamydia pneumoniae-specific IgE is prevalent in asthma and is associated with disease severity.
title_full_unstemmed	Chlamydia pneumoniae-specific IgE is prevalent in asthma and is associated with disease severity.
title_sort	chlamydia pneumoniae-specific ige is prevalent in asthma and is associated with disease severity.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/7210eaf058d44e42b1c01a06f2bc703f
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Chlamydia pneumoniae-specific IgE is prevalent in asthma and is associated with disease severity.

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