Macular dysfunction in drusen maculopathy assessed with multifocal electroretinogram and optical coherence tomography

Jose G Garcia-Garcia,1,2 Jose M Ruiz-Moreno,1 Kristina Holm,2 Sten Andréasson,2 Monica Lövestam-Adrian21Department of Ophthalmology, University of Castilla La Mancha, Albacete, Spain; 2Department of Ophthalmology, University of Lund, Lund, SwedenPurpose: To study the relationship...

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Autores principales:	Garcia-Garcia JG, Ruiz-Moreno JM, Holm K, Andreasson S, L&ouml;vestam-Adrian M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/721315902e774fe195d157a319d5a92c
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spelling	oai:doaj.org-article:721315902e774fe195d157a319d5a92c2021-12-02T02:01:08ZMacular dysfunction in drusen maculopathy assessed with multifocal electroretinogram and optical coherence tomography1177-54671177-5483https://doaj.org/article/721315902e774fe195d157a319d5a92c2013-07-01T00:00:00Zhttp://www.dovepress.com/macular-dysfunction-in-drusen-maculopathy-assessed-with-multifocal-ele-a13520https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Jose G Garcia-Garcia,1,2 Jose M Ruiz-Moreno,1 Kristina Holm,2 Sten Andréasson,2 Monica Lövestam-Adrian21Department of Ophthalmology, University of Castilla La Mancha, Albacete, Spain; 2Department of Ophthalmology, University of Lund, Lund, SwedenPurpose: To study the relationship between macular function assessed by multifocal electroretinogram (mfERG) and morphological changes evaluated with optical coherence tomography (OCT) and fundus photography in patients with drusen maculopathy.Methods: Ten patients (age 71 ± 5 years) with drusen maculopathy were compared to fifteen healthy control patients (age 67 ± 7 years). One eye per patient was examined with OCT, color fundus pictures, and mfERG (103 hexagons) recorded in nine areas corresponding to the nine areas of the OCT retinal map. Drusen density for every separated area was registered.Results: All nine areas in the maculopathy group demonstrated prolonged implicit time compared to healthy controls; the mean value for the maculopathy group was 31.3 milliseconds (95% confidence intervals [CI]: 30.9–31.6) vs 27.9 milliseconds (95% CI: 27.5–28.2; P = 0.006) for the control group. The amplitude in the foveal area was lower in the maculopathy group; the mean value for the maculopathy group was 25.1 nV/deg2 (95% CI: 18.4–31.7) vs 33.9 nV/deg2 (95% CI: 27–40.9; P = 0.03) for the control group. mfERG in the maculopathy group demonstrated no differences in areas with or without drusen. There was no correlation between the retinal thickness assessed with OCT and the mfERG response.Conclusion: Eyes with drusen maculopathy demonstrated functional changes compared to healthy controls evaluated with mfERG. Drusen seems to be associated with general macular dysfunction.Keywords: multifocal electroretinogram, drusen maculopathy, optical coherence tomography, macular dysfunctionGarcia-Garcia JGRuiz-Moreno JMHolm KAndreasson SL&ouml;vestam-Adrian MDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 1303-1309 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Garcia-Garcia JG Ruiz-Moreno JM Holm K Andreasson S L&ouml;vestam-Adrian M Macular dysfunction in drusen maculopathy assessed with multifocal electroretinogram and optical coherence tomography
description	Jose G Garcia-Garcia,1,2 Jose M Ruiz-Moreno,1 Kristina Holm,2 Sten Andréasson,2 Monica Lövestam-Adrian21Department of Ophthalmology, University of Castilla La Mancha, Albacete, Spain; 2Department of Ophthalmology, University of Lund, Lund, SwedenPurpose: To study the relationship between macular function assessed by multifocal electroretinogram (mfERG) and morphological changes evaluated with optical coherence tomography (OCT) and fundus photography in patients with drusen maculopathy.Methods: Ten patients (age 71 ± 5 years) with drusen maculopathy were compared to fifteen healthy control patients (age 67 ± 7 years). One eye per patient was examined with OCT, color fundus pictures, and mfERG (103 hexagons) recorded in nine areas corresponding to the nine areas of the OCT retinal map. Drusen density for every separated area was registered.Results: All nine areas in the maculopathy group demonstrated prolonged implicit time compared to healthy controls; the mean value for the maculopathy group was 31.3 milliseconds (95% confidence intervals [CI]: 30.9–31.6) vs 27.9 milliseconds (95% CI: 27.5–28.2; P = 0.006) for the control group. The amplitude in the foveal area was lower in the maculopathy group; the mean value for the maculopathy group was 25.1 nV/deg2 (95% CI: 18.4–31.7) vs 33.9 nV/deg2 (95% CI: 27–40.9; P = 0.03) for the control group. mfERG in the maculopathy group demonstrated no differences in areas with or without drusen. There was no correlation between the retinal thickness assessed with OCT and the mfERG response.Conclusion: Eyes with drusen maculopathy demonstrated functional changes compared to healthy controls evaluated with mfERG. Drusen seems to be associated with general macular dysfunction.Keywords: multifocal electroretinogram, drusen maculopathy, optical coherence tomography, macular dysfunction
format	article
author	Garcia-Garcia JG Ruiz-Moreno JM Holm K Andreasson S L&ouml;vestam-Adrian M
author_facet	Garcia-Garcia JG Ruiz-Moreno JM Holm K Andreasson S L&ouml;vestam-Adrian M
author_sort	Garcia-Garcia JG
title	Macular dysfunction in drusen maculopathy assessed with multifocal electroretinogram and optical coherence tomography
title_short	Macular dysfunction in drusen maculopathy assessed with multifocal electroretinogram and optical coherence tomography
title_full	Macular dysfunction in drusen maculopathy assessed with multifocal electroretinogram and optical coherence tomography
title_fullStr	Macular dysfunction in drusen maculopathy assessed with multifocal electroretinogram and optical coherence tomography
title_full_unstemmed	Macular dysfunction in drusen maculopathy assessed with multifocal electroretinogram and optical coherence tomography
title_sort	macular dysfunction in drusen maculopathy assessed with multifocal electroretinogram and optical coherence tomography
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/721315902e774fe195d157a319d5a92c
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Macular dysfunction in drusen maculopathy assessed with multifocal electroretinogram and optical coherence tomography

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