MicroRNAs: Their Role in Metabolism, Tumor Microenvironment, and Therapeutic Implications in Head and Neck Squamous Cell Carcinoma

MicroRNAs (miRNAs) are endogenous small non-coding RNA molecules that negatively regulate gene expression by binding to target mRNAs. Deregulated miRNAs can act as either oncogenic miRNAs or tumor suppressor miRNAs in controlling proliferation, differentiation, apoptosis, metastasis, epithelial–mese...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shine-Gwo Shiah, Sung-Tau Chou, Jang-Yang Chang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	miRNA HNSCC metabolism exosomes tumor microenvironment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/7213bfb800ac4f36a6d932fffd763348
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7213bfb800ac4f36a6d932fffd763348
record_format	dspace
spelling	oai:doaj.org-article:7213bfb800ac4f36a6d932fffd7633482021-11-25T17:01:14ZMicroRNAs: Their Role in Metabolism, Tumor Microenvironment, and Therapeutic Implications in Head and Neck Squamous Cell Carcinoma10.3390/cancers132256042072-6694https://doaj.org/article/7213bfb800ac4f36a6d932fffd7633482021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5604https://doaj.org/toc/2072-6694MicroRNAs (miRNAs) are endogenous small non-coding RNA molecules that negatively regulate gene expression by binding to target mRNAs. Deregulated miRNAs can act as either oncogenic miRNAs or tumor suppressor miRNAs in controlling proliferation, differentiation, apoptosis, metastasis, epithelial–mesenchymal transition, and immune responses, which are all involved in the carcinogenesis process of HNSCC. Recent findings have shown that metabolic reprogramming is an important hallmark of cancer, which is necessary for malignant transformation and tumor development. Some reprogrammed metabolisms are believed to be required for HNSCC against an unfavorable tumor microenvironment (TME). The TME is composed of various cell types embedded in the altered extracellular matrix, among which exosomes, secreted by cancer cells, are one of the most important factors. Tumor-derived exosomes reshape the tumor microenvironment and play a crucial role in cell-to-cell communication during HNSCC development. Exosomes encapsulate many biomolecules, including miRNAs, circulate in body fluids, and can transmit intercellular regulatory messages to nearby and distant sites, which indicates that exosomal miRNAs have the potential to become non-invasive biomarkers. This review aims to clarify the functions of diverse miRNAs in HNSCC metabolic reprogramming and tumor-derived exosomes. In addition, it also emphasizes the potential role of miRNA as a biomarker in the diagnosis, prognosis, and treatment of HNSCC cancer.Shine-Gwo ShiahSung-Tau ChouJang-Yang ChangMDPI AGarticlemiRNAHNSCCmetabolismexosomestumor microenvironmentNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5604, p 5604 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	miRNA HNSCC metabolism exosomes tumor microenvironment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	miRNA HNSCC metabolism exosomes tumor microenvironment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Shine-Gwo Shiah Sung-Tau Chou Jang-Yang Chang MicroRNAs: Their Role in Metabolism, Tumor Microenvironment, and Therapeutic Implications in Head and Neck Squamous Cell Carcinoma
description	MicroRNAs (miRNAs) are endogenous small non-coding RNA molecules that negatively regulate gene expression by binding to target mRNAs. Deregulated miRNAs can act as either oncogenic miRNAs or tumor suppressor miRNAs in controlling proliferation, differentiation, apoptosis, metastasis, epithelial–mesenchymal transition, and immune responses, which are all involved in the carcinogenesis process of HNSCC. Recent findings have shown that metabolic reprogramming is an important hallmark of cancer, which is necessary for malignant transformation and tumor development. Some reprogrammed metabolisms are believed to be required for HNSCC against an unfavorable tumor microenvironment (TME). The TME is composed of various cell types embedded in the altered extracellular matrix, among which exosomes, secreted by cancer cells, are one of the most important factors. Tumor-derived exosomes reshape the tumor microenvironment and play a crucial role in cell-to-cell communication during HNSCC development. Exosomes encapsulate many biomolecules, including miRNAs, circulate in body fluids, and can transmit intercellular regulatory messages to nearby and distant sites, which indicates that exosomal miRNAs have the potential to become non-invasive biomarkers. This review aims to clarify the functions of diverse miRNAs in HNSCC metabolic reprogramming and tumor-derived exosomes. In addition, it also emphasizes the potential role of miRNA as a biomarker in the diagnosis, prognosis, and treatment of HNSCC cancer.
format	article
author	Shine-Gwo Shiah Sung-Tau Chou Jang-Yang Chang
author_facet	Shine-Gwo Shiah Sung-Tau Chou Jang-Yang Chang
author_sort	Shine-Gwo Shiah
title	MicroRNAs: Their Role in Metabolism, Tumor Microenvironment, and Therapeutic Implications in Head and Neck Squamous Cell Carcinoma
title_short	MicroRNAs: Their Role in Metabolism, Tumor Microenvironment, and Therapeutic Implications in Head and Neck Squamous Cell Carcinoma
title_full	MicroRNAs: Their Role in Metabolism, Tumor Microenvironment, and Therapeutic Implications in Head and Neck Squamous Cell Carcinoma
title_fullStr	MicroRNAs: Their Role in Metabolism, Tumor Microenvironment, and Therapeutic Implications in Head and Neck Squamous Cell Carcinoma
title_full_unstemmed	MicroRNAs: Their Role in Metabolism, Tumor Microenvironment, and Therapeutic Implications in Head and Neck Squamous Cell Carcinoma
title_sort	micrornas: their role in metabolism, tumor microenvironment, and therapeutic implications in head and neck squamous cell carcinoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7213bfb800ac4f36a6d932fffd763348
work_keys_str_mv	AT shinegwoshiah micrornastheirroleinmetabolismtumormicroenvironmentandtherapeuticimplicationsinheadandnecksquamouscellcarcinoma AT sungtauchou micrornastheirroleinmetabolismtumormicroenvironmentandtherapeuticimplicationsinheadandnecksquamouscellcarcinoma AT jangyangchang micrornastheirroleinmetabolismtumormicroenvironmentandtherapeuticimplicationsinheadandnecksquamouscellcarcinoma
_version_	1718412782578171904

MicroRNAs: Their Role in Metabolism, Tumor Microenvironment, and Therapeutic Implications in Head and Neck Squamous Cell Carcinoma

Ejemplares similares