Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish

Butti et al. generate a C9orf72 loss-of-function model in zebrafish. They find that that C9orf72 is required for presynaptic vesicle trafficking and release at the zebrafish larval neuromuscular junctions. This study provides functional insights into the pathogenesis of amyotrophic lateral sclerosis...

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Autores principales:	Zoé Butti, Yingzhou Edward Pan, Jean Giacomotto, Shunmoogum A. Patten
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/721401a8b8eb4a4ea4abee48a68082dc
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spelling	oai:doaj.org-article:721401a8b8eb4a4ea4abee48a68082dc2021-12-02T18:02:53ZReduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish10.1038/s42003-021-02302-y2399-3642https://doaj.org/article/721401a8b8eb4a4ea4abee48a68082dc2021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02302-yhttps://doaj.org/toc/2399-3642Butti et al. generate a C9orf72 loss-of-function model in zebrafish. They find that that C9orf72 is required for presynaptic vesicle trafficking and release at the zebrafish larval neuromuscular junctions. This study provides functional insights into the pathogenesis of amyotrophic lateral sclerosis and fronto-temporal dementia.Zoé ButtiYingzhou Edward PanJean GiacomottoShunmoogum A. PattenNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Zoé Butti Yingzhou Edward Pan Jean Giacomotto Shunmoogum A. Patten Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish
description	Butti et al. generate a C9orf72 loss-of-function model in zebrafish. They find that that C9orf72 is required for presynaptic vesicle trafficking and release at the zebrafish larval neuromuscular junctions. This study provides functional insights into the pathogenesis of amyotrophic lateral sclerosis and fronto-temporal dementia.
format	article
author	Zoé Butti Yingzhou Edward Pan Jean Giacomotto Shunmoogum A. Patten
author_facet	Zoé Butti Yingzhou Edward Pan Jean Giacomotto Shunmoogum A. Patten
author_sort	Zoé Butti
title	Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish
title_short	Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish
title_full	Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish
title_fullStr	Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish
title_full_unstemmed	Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish
title_sort	reduced c9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/721401a8b8eb4a4ea4abee48a68082dc
work_keys_str_mv	AT zoebutti reducedc9orf72functionleadstodefectivesynapticvesiclereleaseandneuromusculardysfunctioninzebrafish AT yingzhouedwardpan reducedc9orf72functionleadstodefectivesynapticvesiclereleaseandneuromusculardysfunctioninzebrafish AT jeangiacomotto reducedc9orf72functionleadstodefectivesynapticvesiclereleaseandneuromusculardysfunctioninzebrafish AT shunmoogumapatten reducedc9orf72functionleadstodefectivesynapticvesiclereleaseandneuromusculardysfunctioninzebrafish
_version_	1718378814217650176

Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish

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