NY-ESO-1-specific circulating CD4+ T cells in ovarian cancer patients are prevalently T(H)1 type cells undetectable in the CD25+ FOXP3+ Treg compartment.

Spontaneous CD4(+) T-cell responses to the tumor-specific antigen NY-ESO-1 (ESO) are frequently found in patients with epithelial ovarian cancer (EOC). If these responses are of effector or/and Treg type, however, has remained unclear. Here, we have used functional approaches together with recently...

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Autores principales:	Nassima Redjimi, Karine Duperrier-Amouriaux, Isabelle Raimbaud, Immanuel Luescher, Danijel Dojcinovic, Jean-Marc Classe, Dominique Berton-Rigaud, Jean-Sébastien Frenel, Emmanuelle Bourbouloux, Danila Valmori, Maha Ayyoub
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/72191bbdfda1414c9260fa0ce840fd80
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spelling	oai:doaj.org-article:72191bbdfda1414c9260fa0ce840fd802021-11-18T06:49:01ZNY-ESO-1-specific circulating CD4+ T cells in ovarian cancer patients are prevalently T(H)1 type cells undetectable in the CD25+ FOXP3+ Treg compartment.1932-620310.1371/journal.pone.0022845https://doaj.org/article/72191bbdfda1414c9260fa0ce840fd802011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21829534/?tool=EBIhttps://doaj.org/toc/1932-6203Spontaneous CD4(+) T-cell responses to the tumor-specific antigen NY-ESO-1 (ESO) are frequently found in patients with epithelial ovarian cancer (EOC). If these responses are of effector or/and Treg type, however, has remained unclear. Here, we have used functional approaches together with recently developed MHC class II/ESO tetramers to assess the frequency, phenotype and function of ESO-specific cells in circulating lymphocytes from EOC patients. We found that circulating ESO-specific CD4(+) T cells in EOC patients with spontaneous immune responses to the antigen are prevalently T(H)1 type cells secreting IFN-γ but no IL-17 or IL-10 and are not suppressive. We detected tetramer(+) cells ex vivo, at an average frequency of 1:25,000 memory cells, that is, significantly lower than in patients immunized with an ESO vaccine. ESO tetramer(+) cells were mostly effector memory cells at advanced stages of differentiation and were not detected in circulating CD25(+)FOXP3(+)Treg. Thus, spontaneous CD4(+) T-cell responses to ESO in cancer patients are prevalently of T(H)1 type and not Treg. Their relatively low frequency and advanced differentiation stage, however, may limit their efficacy, that may be boosted by immunogenic ESO vaccines.Nassima RedjimiKarine Duperrier-AmouriauxIsabelle RaimbaudImmanuel LuescherDanijel DojcinovicJean-Marc ClasseDominique Berton-RigaudJean-Sébastien FrenelEmmanuelle BourboulouxDanila ValmoriMaha AyyoubPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e22845 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nassima Redjimi Karine Duperrier-Amouriaux Isabelle Raimbaud Immanuel Luescher Danijel Dojcinovic Jean-Marc Classe Dominique Berton-Rigaud Jean-Sébastien Frenel Emmanuelle Bourbouloux Danila Valmori Maha Ayyoub NY-ESO-1-specific circulating CD4+ T cells in ovarian cancer patients are prevalently T(H)1 type cells undetectable in the CD25+ FOXP3+ Treg compartment.
description	Spontaneous CD4(+) T-cell responses to the tumor-specific antigen NY-ESO-1 (ESO) are frequently found in patients with epithelial ovarian cancer (EOC). If these responses are of effector or/and Treg type, however, has remained unclear. Here, we have used functional approaches together with recently developed MHC class II/ESO tetramers to assess the frequency, phenotype and function of ESO-specific cells in circulating lymphocytes from EOC patients. We found that circulating ESO-specific CD4(+) T cells in EOC patients with spontaneous immune responses to the antigen are prevalently T(H)1 type cells secreting IFN-γ but no IL-17 or IL-10 and are not suppressive. We detected tetramer(+) cells ex vivo, at an average frequency of 1:25,000 memory cells, that is, significantly lower than in patients immunized with an ESO vaccine. ESO tetramer(+) cells were mostly effector memory cells at advanced stages of differentiation and were not detected in circulating CD25(+)FOXP3(+)Treg. Thus, spontaneous CD4(+) T-cell responses to ESO in cancer patients are prevalently of T(H)1 type and not Treg. Their relatively low frequency and advanced differentiation stage, however, may limit their efficacy, that may be boosted by immunogenic ESO vaccines.
format	article
author	Nassima Redjimi Karine Duperrier-Amouriaux Isabelle Raimbaud Immanuel Luescher Danijel Dojcinovic Jean-Marc Classe Dominique Berton-Rigaud Jean-Sébastien Frenel Emmanuelle Bourbouloux Danila Valmori Maha Ayyoub
author_facet	Nassima Redjimi Karine Duperrier-Amouriaux Isabelle Raimbaud Immanuel Luescher Danijel Dojcinovic Jean-Marc Classe Dominique Berton-Rigaud Jean-Sébastien Frenel Emmanuelle Bourbouloux Danila Valmori Maha Ayyoub
author_sort	Nassima Redjimi
title	NY-ESO-1-specific circulating CD4+ T cells in ovarian cancer patients are prevalently T(H)1 type cells undetectable in the CD25+ FOXP3+ Treg compartment.
title_short	NY-ESO-1-specific circulating CD4+ T cells in ovarian cancer patients are prevalently T(H)1 type cells undetectable in the CD25+ FOXP3+ Treg compartment.
title_full	NY-ESO-1-specific circulating CD4+ T cells in ovarian cancer patients are prevalently T(H)1 type cells undetectable in the CD25+ FOXP3+ Treg compartment.
title_fullStr	NY-ESO-1-specific circulating CD4+ T cells in ovarian cancer patients are prevalently T(H)1 type cells undetectable in the CD25+ FOXP3+ Treg compartment.
title_full_unstemmed	NY-ESO-1-specific circulating CD4+ T cells in ovarian cancer patients are prevalently T(H)1 type cells undetectable in the CD25+ FOXP3+ Treg compartment.
title_sort	ny-eso-1-specific circulating cd4+ t cells in ovarian cancer patients are prevalently t(h)1 type cells undetectable in the cd25+ foxp3+ treg compartment.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/72191bbdfda1414c9260fa0ce840fd80
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NY-ESO-1-specific circulating CD4+ T cells in ovarian cancer patients are prevalently T(H)1 type cells undetectable in the CD25+ FOXP3+ Treg compartment.

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