The association between psychological stress and miscarriage: A systematic review and meta-analysis

Abstract This systematic review and meta-analysis was designed to investigate whether maternal psychological stress and recent life events are associated with an increased risk of miscarriage. A literature search was conducted to identify studies reporting miscarriage in women with and without histo...

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Autores principales:	Fan Qu, Yan Wu, Yu-Hang Zhu, John Barry, Tao Ding, Gianluca Baio, Ruth Muscat, Brenda K. Todd, Fang-Fang Wang, Paul J Hardiman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/722140c0cf634ca7bc837ce05016982f
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spelling	oai:doaj.org-article:722140c0cf634ca7bc837ce05016982f2021-12-02T12:30:52ZThe association between psychological stress and miscarriage: A systematic review and meta-analysis10.1038/s41598-017-01792-32045-2322https://doaj.org/article/722140c0cf634ca7bc837ce05016982f2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01792-3https://doaj.org/toc/2045-2322Abstract This systematic review and meta-analysis was designed to investigate whether maternal psychological stress and recent life events are associated with an increased risk of miscarriage. A literature search was conducted to identify studies reporting miscarriage in women with and without history of exposure to psychological stress (the only exposure considered). The search produced 1978 studies; 8 studies were suitable for analysis. A meta-analysis was performed using a random-effects model with effect sizes weighted by the sampling variance. The risk of miscarriage was significantly higher in women with a history of exposure to psychological stress (OR 1.42, 95% CI 1.19–1.70). These findings remained after controlling for study type (cohort and nested case-control study OR 1.33 95% CI 1.14–1.54), exposure types (work stress OR 1.27, 95% CI 1.10–1.47), types of controls included (live birth OR 2.82 95% CI: 1.64–4.86). We found no evidence that publication bias or study heterogeneity significantly influenced the results. Our finding provides the most robust evidence to date, that prior psychological stress is harmful to women in early pregnancy.Fan QuYan WuYu-Hang ZhuJohn BarryTao DingGianluca BaioRuth MuscatBrenda K. ToddFang-Fang WangPaul J HardimanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fan Qu Yan Wu Yu-Hang Zhu John Barry Tao Ding Gianluca Baio Ruth Muscat Brenda K. Todd Fang-Fang Wang Paul J Hardiman The association between psychological stress and miscarriage: A systematic review and meta-analysis
description	Abstract This systematic review and meta-analysis was designed to investigate whether maternal psychological stress and recent life events are associated with an increased risk of miscarriage. A literature search was conducted to identify studies reporting miscarriage in women with and without history of exposure to psychological stress (the only exposure considered). The search produced 1978 studies; 8 studies were suitable for analysis. A meta-analysis was performed using a random-effects model with effect sizes weighted by the sampling variance. The risk of miscarriage was significantly higher in women with a history of exposure to psychological stress (OR 1.42, 95% CI 1.19–1.70). These findings remained after controlling for study type (cohort and nested case-control study OR 1.33 95% CI 1.14–1.54), exposure types (work stress OR 1.27, 95% CI 1.10–1.47), types of controls included (live birth OR 2.82 95% CI: 1.64–4.86). We found no evidence that publication bias or study heterogeneity significantly influenced the results. Our finding provides the most robust evidence to date, that prior psychological stress is harmful to women in early pregnancy.
format	article
author	Fan Qu Yan Wu Yu-Hang Zhu John Barry Tao Ding Gianluca Baio Ruth Muscat Brenda K. Todd Fang-Fang Wang Paul J Hardiman
author_facet	Fan Qu Yan Wu Yu-Hang Zhu John Barry Tao Ding Gianluca Baio Ruth Muscat Brenda K. Todd Fang-Fang Wang Paul J Hardiman
author_sort	Fan Qu
title	The association between psychological stress and miscarriage: A systematic review and meta-analysis
title_short	The association between psychological stress and miscarriage: A systematic review and meta-analysis
title_full	The association between psychological stress and miscarriage: A systematic review and meta-analysis
title_fullStr	The association between psychological stress and miscarriage: A systematic review and meta-analysis
title_full_unstemmed	The association between psychological stress and miscarriage: A systematic review and meta-analysis
title_sort	association between psychological stress and miscarriage: a systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/722140c0cf634ca7bc837ce05016982f
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The association between psychological stress and miscarriage: A systematic review and meta-analysis

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