miRNA, lncRNA and circRNA: Targeted Molecules Full of Therapeutic Prospects in the Development of Diabetic Retinopathy

Diabetic retinopathy (DR) is a common diabetic complication and the main cause of blindness worldwide, which seriously affects the quality of life of patients. Studies have shown that noncoding RNA (ncRNA) has distinct differentiated expression in DR and plays an important role in the occurrence and...

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Autores principales:	Xingyu Chang, Guomao Zhu, Zongyan Cai, Yaqi Wang, Rongna Lian, Xulei Tang, Chengxu Ma, Songbo Fu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	diabetic retinopathy miRNA lncRNA circRNA diabetes Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/722444a50177401ba00a10b1e7d93cd3
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spelling	oai:doaj.org-article:722444a50177401ba00a10b1e7d93cd32021-11-10T07:37:25ZmiRNA, lncRNA and circRNA: Targeted Molecules Full of Therapeutic Prospects in the Development of Diabetic Retinopathy1664-239210.3389/fendo.2021.771552https://doaj.org/article/722444a50177401ba00a10b1e7d93cd32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.771552/fullhttps://doaj.org/toc/1664-2392Diabetic retinopathy (DR) is a common diabetic complication and the main cause of blindness worldwide, which seriously affects the quality of life of patients. Studies have shown that noncoding RNA (ncRNA) has distinct differentiated expression in DR and plays an important role in the occurrence and development of DR. ncRNAs represented by microRNAs (miRNAs), lncRNAs (lncRNAs), and circRNAs (circRNAs) have been shown to be widely involved in the regulation of gene expression and affect multiple biological processes of retinopathy. This article will review three RNAs related to the occurrence and development of DR on the basis of previous studies (especially their effects on retinal microangiopathy, retinal pigment epithelial cells, and retinal nerve cells) and discuss their underlying mechanisms and connections. Overall, this review will help us better understand the role of ncRNAs in the occurrence and development of DR and provide ideas for exploring potential therapeutic directions and targets.Xingyu ChangGuomao ZhuZongyan CaiYaqi WangRongna LianXulei TangXulei TangXulei TangChengxu MaChengxu MaSongbo FuSongbo FuSongbo FuFrontiers Media S.A.articlediabetic retinopathymiRNAlncRNAcircRNAdiabetesDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic retinopathy miRNA lncRNA circRNA diabetes Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	diabetic retinopathy miRNA lncRNA circRNA diabetes Diseases of the endocrine glands. Clinical endocrinology RC648-665 Xingyu Chang Guomao Zhu Zongyan Cai Yaqi Wang Rongna Lian Xulei Tang Xulei Tang Xulei Tang Chengxu Ma Chengxu Ma Songbo Fu Songbo Fu Songbo Fu miRNA, lncRNA and circRNA: Targeted Molecules Full of Therapeutic Prospects in the Development of Diabetic Retinopathy
description	Diabetic retinopathy (DR) is a common diabetic complication and the main cause of blindness worldwide, which seriously affects the quality of life of patients. Studies have shown that noncoding RNA (ncRNA) has distinct differentiated expression in DR and plays an important role in the occurrence and development of DR. ncRNAs represented by microRNAs (miRNAs), lncRNAs (lncRNAs), and circRNAs (circRNAs) have been shown to be widely involved in the regulation of gene expression and affect multiple biological processes of retinopathy. This article will review three RNAs related to the occurrence and development of DR on the basis of previous studies (especially their effects on retinal microangiopathy, retinal pigment epithelial cells, and retinal nerve cells) and discuss their underlying mechanisms and connections. Overall, this review will help us better understand the role of ncRNAs in the occurrence and development of DR and provide ideas for exploring potential therapeutic directions and targets.
format	article
author	Xingyu Chang Guomao Zhu Zongyan Cai Yaqi Wang Rongna Lian Xulei Tang Xulei Tang Xulei Tang Chengxu Ma Chengxu Ma Songbo Fu Songbo Fu Songbo Fu
author_facet	Xingyu Chang Guomao Zhu Zongyan Cai Yaqi Wang Rongna Lian Xulei Tang Xulei Tang Xulei Tang Chengxu Ma Chengxu Ma Songbo Fu Songbo Fu Songbo Fu
author_sort	Xingyu Chang
title	miRNA, lncRNA and circRNA: Targeted Molecules Full of Therapeutic Prospects in the Development of Diabetic Retinopathy
title_short	miRNA, lncRNA and circRNA: Targeted Molecules Full of Therapeutic Prospects in the Development of Diabetic Retinopathy
title_full	miRNA, lncRNA and circRNA: Targeted Molecules Full of Therapeutic Prospects in the Development of Diabetic Retinopathy
title_fullStr	miRNA, lncRNA and circRNA: Targeted Molecules Full of Therapeutic Prospects in the Development of Diabetic Retinopathy
title_full_unstemmed	miRNA, lncRNA and circRNA: Targeted Molecules Full of Therapeutic Prospects in the Development of Diabetic Retinopathy
title_sort	mirna, lncrna and circrna: targeted molecules full of therapeutic prospects in the development of diabetic retinopathy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/722444a50177401ba00a10b1e7d93cd3
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miRNA, lncRNA and circRNA: Targeted Molecules Full of Therapeutic Prospects in the Development of Diabetic Retinopathy

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