Computational Analysis of Lung and Isolated Airway Bifurcations under Mechanical Ventilation and Normal Breathing

Mechanical ventilation is required for many patients who cannot breathe normally as a result of lung disease and other factors that result in reduced lung function. In this study, we investigated the effects of mechanical ventilation and normal breathing on whole lung geometry as well as isolated bi...

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Autores principales:	Jongwon Kim, Ramana M. Pidaparti
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	lung airway bifurcations computations mechanical ventilation normal breathing Thermodynamics QC310.15-319 Descriptive and experimental mechanics QC120-168.85
Acceso en línea:	https://doaj.org/article/7224ce919e1548aca57b800e334ba070
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spelling	oai:doaj.org-article:7224ce919e1548aca57b800e334ba0702021-11-25T17:31:32ZComputational Analysis of Lung and Isolated Airway Bifurcations under Mechanical Ventilation and Normal Breathing10.3390/fluids61103882311-5521https://doaj.org/article/7224ce919e1548aca57b800e334ba0702021-10-01T00:00:00Zhttps://www.mdpi.com/2311-5521/6/11/388https://doaj.org/toc/2311-5521Mechanical ventilation is required for many patients who cannot breathe normally as a result of lung disease and other factors that result in reduced lung function. In this study, we investigated the effects of mechanical ventilation and normal breathing on whole lung geometry as well as isolated bifurcations through computational fluid dynamic (CFD) simulations. Results of flow characteristics (airflow velocity, wall pressure, and wall shear stress) obtained from the CFD simulations are presented. Similar flow patterns and pressure drops were obtained between the whole lung geometry and isolated bifurcations under both normal breathing and mechanical ventilation, respectively. Results obtained from simulations suggest that analyzing specific local bifurcations may be a more feasible alternative as it may reduce the computational time and numerical errors resulting from computations as compared to simulating a complex whole lung geometry. The approach presented in this study also demonstrated that analyses of isolated bifurcations gave similar flow characteristics to that of whole lung geometry. Therefore, this approach may be useful for quickly obtaining results that will assist in making clinical predictions and other applications.Jongwon KimRamana M. PidapartiMDPI AGarticlelungairway bifurcationscomputationsmechanical ventilationnormal breathingThermodynamicsQC310.15-319Descriptive and experimental mechanicsQC120-168.85ENFluids, Vol 6, Iss 388, p 388 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lung airway bifurcations computations mechanical ventilation normal breathing Thermodynamics QC310.15-319 Descriptive and experimental mechanics QC120-168.85
spellingShingle	lung airway bifurcations computations mechanical ventilation normal breathing Thermodynamics QC310.15-319 Descriptive and experimental mechanics QC120-168.85 Jongwon Kim Ramana M. Pidaparti Computational Analysis of Lung and Isolated Airway Bifurcations under Mechanical Ventilation and Normal Breathing
description	Mechanical ventilation is required for many patients who cannot breathe normally as a result of lung disease and other factors that result in reduced lung function. In this study, we investigated the effects of mechanical ventilation and normal breathing on whole lung geometry as well as isolated bifurcations through computational fluid dynamic (CFD) simulations. Results of flow characteristics (airflow velocity, wall pressure, and wall shear stress) obtained from the CFD simulations are presented. Similar flow patterns and pressure drops were obtained between the whole lung geometry and isolated bifurcations under both normal breathing and mechanical ventilation, respectively. Results obtained from simulations suggest that analyzing specific local bifurcations may be a more feasible alternative as it may reduce the computational time and numerical errors resulting from computations as compared to simulating a complex whole lung geometry. The approach presented in this study also demonstrated that analyses of isolated bifurcations gave similar flow characteristics to that of whole lung geometry. Therefore, this approach may be useful for quickly obtaining results that will assist in making clinical predictions and other applications.
format	article
author	Jongwon Kim Ramana M. Pidaparti
author_facet	Jongwon Kim Ramana M. Pidaparti
author_sort	Jongwon Kim
title	Computational Analysis of Lung and Isolated Airway Bifurcations under Mechanical Ventilation and Normal Breathing
title_short	Computational Analysis of Lung and Isolated Airway Bifurcations under Mechanical Ventilation and Normal Breathing
title_full	Computational Analysis of Lung and Isolated Airway Bifurcations under Mechanical Ventilation and Normal Breathing
title_fullStr	Computational Analysis of Lung and Isolated Airway Bifurcations under Mechanical Ventilation and Normal Breathing
title_full_unstemmed	Computational Analysis of Lung and Isolated Airway Bifurcations under Mechanical Ventilation and Normal Breathing
title_sort	computational analysis of lung and isolated airway bifurcations under mechanical ventilation and normal breathing
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7224ce919e1548aca57b800e334ba070
work_keys_str_mv	AT jongwonkim computationalanalysisoflungandisolatedairwaybifurcationsundermechanicalventilationandnormalbreathing AT ramanampidaparti computationalanalysisoflungandisolatedairwaybifurcationsundermechanicalventilationandnormalbreathing
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Computational Analysis of Lung and Isolated Airway Bifurcations under Mechanical Ventilation and Normal Breathing

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