Conserved and species-specific molecular denominators in mammalian skeletal muscle aging

Conserved and unique aging regulatory pathways Aging is a complex phenomenon involving functional declines in multiple physiological systems with the passage of time. Focusing on skeletal muscle, a group of international scientists identified pathways involved in healthspan and by determining global...

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Autores principales:	Evi M. Mercken, Miriam Capri, Bethany A. Carboneau, Maria Conte, Juliana Heidler, Aurelia Santoro, Alejandro Martin-Montalvo, Marta Gonzalez-Freire, Husam Khraiwesh, José A. González-Reyes, Ruin Moaddel, Yongqing Zhang, Kevin G. Becker, José M. Villalba, Julie A. Mattison, Ilka Wittig, Claudio Franceschi, Rafael de Cabo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/7226c7ed427e4ac3ac7634971f4fca38
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spelling	oai:doaj.org-article:7226c7ed427e4ac3ac7634971f4fca382021-12-02T13:41:46ZConserved and species-specific molecular denominators in mammalian skeletal muscle aging10.1038/s41514-017-0009-82056-3973https://doaj.org/article/7226c7ed427e4ac3ac7634971f4fca382017-05-01T00:00:00Zhttps://doi.org/10.1038/s41514-017-0009-8https://doaj.org/toc/2056-3973Conserved and unique aging regulatory pathways Aging is a complex phenomenon involving functional declines in multiple physiological systems with the passage of time. Focusing on skeletal muscle, a group of international scientists identified pathways involved in healthspan and by determining global gene expression profiles across species they exposed common mechanisms fundamental to the aging process. Their experimental design involved comparative analysis of mice, rats, rhesus monkeys and humans, targeting three key time points during their respective lifespans. Pathways related to oxidative stress, inflammation and nutrient signaling, which function collectively to affect the quality and status of mitochondria, emerged across all species in an age-influenced manner. The identification of conserved pathways reveals molecular mechanisms intrinsic to health and survival, whereas the unveiling of species-specific pathways emphasizes the importance of human studies for devising optimal therapeutic modalities to slow the aging process.Evi M. MerckenMiriam CapriBethany A. CarboneauMaria ConteJuliana HeidlerAurelia SantoroAlejandro Martin-MontalvoMarta Gonzalez-FreireHusam KhraiweshJosé A. González-ReyesRuin MoaddelYongqing ZhangKevin G. BeckerJosé M. VillalbaJulie A. MattisonIlka WittigClaudio FranceschiRafael de CaboNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 3, Iss 1, Pp 1-22 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Evi M. Mercken Miriam Capri Bethany A. Carboneau Maria Conte Juliana Heidler Aurelia Santoro Alejandro Martin-Montalvo Marta Gonzalez-Freire Husam Khraiwesh José A. González-Reyes Ruin Moaddel Yongqing Zhang Kevin G. Becker José M. Villalba Julie A. Mattison Ilka Wittig Claudio Franceschi Rafael de Cabo Conserved and species-specific molecular denominators in mammalian skeletal muscle aging
description	Conserved and unique aging regulatory pathways Aging is a complex phenomenon involving functional declines in multiple physiological systems with the passage of time. Focusing on skeletal muscle, a group of international scientists identified pathways involved in healthspan and by determining global gene expression profiles across species they exposed common mechanisms fundamental to the aging process. Their experimental design involved comparative analysis of mice, rats, rhesus monkeys and humans, targeting three key time points during their respective lifespans. Pathways related to oxidative stress, inflammation and nutrient signaling, which function collectively to affect the quality and status of mitochondria, emerged across all species in an age-influenced manner. The identification of conserved pathways reveals molecular mechanisms intrinsic to health and survival, whereas the unveiling of species-specific pathways emphasizes the importance of human studies for devising optimal therapeutic modalities to slow the aging process.
format	article
author	Evi M. Mercken Miriam Capri Bethany A. Carboneau Maria Conte Juliana Heidler Aurelia Santoro Alejandro Martin-Montalvo Marta Gonzalez-Freire Husam Khraiwesh José A. González-Reyes Ruin Moaddel Yongqing Zhang Kevin G. Becker José M. Villalba Julie A. Mattison Ilka Wittig Claudio Franceschi Rafael de Cabo
author_facet	Evi M. Mercken Miriam Capri Bethany A. Carboneau Maria Conte Juliana Heidler Aurelia Santoro Alejandro Martin-Montalvo Marta Gonzalez-Freire Husam Khraiwesh José A. González-Reyes Ruin Moaddel Yongqing Zhang Kevin G. Becker José M. Villalba Julie A. Mattison Ilka Wittig Claudio Franceschi Rafael de Cabo
author_sort	Evi M. Mercken
title	Conserved and species-specific molecular denominators in mammalian skeletal muscle aging
title_short	Conserved and species-specific molecular denominators in mammalian skeletal muscle aging
title_full	Conserved and species-specific molecular denominators in mammalian skeletal muscle aging
title_fullStr	Conserved and species-specific molecular denominators in mammalian skeletal muscle aging
title_full_unstemmed	Conserved and species-specific molecular denominators in mammalian skeletal muscle aging
title_sort	conserved and species-specific molecular denominators in mammalian skeletal muscle aging
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7226c7ed427e4ac3ac7634971f4fca38
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_version_	1718392559802253312

Conserved and species-specific molecular denominators in mammalian skeletal muscle aging

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