Main Risk Factors Related to Activities of Daily Living in Non-Dialysis Patients with Chronic Kidney Disease Stage 3–5: A Case–Control Study
Jing Chang,* Wen-Wen Hou,* Yan-Fei Wang, Qian-Mei Sun Department of Internal Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qian-Mei Sun Email sunqianmei5825@126.comIntroduct...
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2020
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oai:doaj.org-article:72271aa85d8443739e3bbb799128f9382021-12-02T12:10:54ZMain Risk Factors Related to Activities of Daily Living in Non-Dialysis Patients with Chronic Kidney Disease Stage 3–5: A Case–Control Study1178-1998https://doaj.org/article/72271aa85d8443739e3bbb799128f9382020-05-01T00:00:00Zhttps://www.dovepress.com/main-risk-factors-related-to-activities-of-daily-living-in-non-dialysi-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Jing Chang,* Wen-Wen Hou,* Yan-Fei Wang, Qian-Mei Sun Department of Internal Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qian-Mei Sun Email sunqianmei5825@126.comIntroduction: Elderly people are at increased risk of falls, disability and death due to reduced functional reserve, decline in multiple systems functions, which affects their activities of daily living (ADL) and eventually develop into frailty. The ADL assessment is conducive to early detection to avoid further serious situations. Previous studies on patients’ activities of daily living with chronic kidney disease (CKD) are mainly focused on dialysis patients. Little information is available on non-dialysis patients.Patients and Methods: A total of 303 elderly patients with CKD stage 3– 5 who were admitted to our hospital were selected. ADL evaluation was performed on patients at admission, with Barthel index (BI) as the evaluation tool. They were divided into two groups based on BI (≥ 60 and < 60). Demographic information, lifestyle and clinical profile were collected. The risk factors related to ADL were analyzed by univariate and multivariate models.Results: The data of 303 patients enrolled in this study were analyzed. The average age of patients was 84.48± 7.14 years and 62.05% were male. There were 88 patients (29.04%) in BI < 60 group and 215 patients (70.96%) in the BI ≥ 60 group. The average age of subjects in the two groups was 87.47 ± 5.85 years and 83.26± 7.28 years, respectively. On univariate analysis, ADL impairment was associated with many factors, such as age, body mass index, blood lipid, heart rate, smoking history, Charlson comorbidity index (CCI), hemoglobin, serum albumin, BNP, eGFR, etc. Multivariate logistic regression showed that age (OR 1.08, 95% CI 1.00– 1.17, P=0.0390), Charlson comorbidity index (OR 4.75, 95% CI 1.17– 19.30, P=0.0295), and serum albumin (OR 0.80, 95% CI 0.70– 0.92, P=0.0012) were the independent risk factors of ADL impairment.Conclusion: Decline of ADL in CKD patients was independently correlated with age, Charlson comorbidity index and serum albumin. ADL and its influential factors in the elderly CKD patients deserve further attention.Keywords: chronic kidney disease, activities of daily living, risk factorsChang JHou WWWang YFSun QMDove Medical Pressarticlechronic kidney diseaseactivities of daily livingrisk factors.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 15, Pp 609-618 (2020) |
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chronic kidney disease activities of daily living risk factors. Geriatrics RC952-954.6 |
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chronic kidney disease activities of daily living risk factors. Geriatrics RC952-954.6 Chang J Hou WW Wang YF Sun QM Main Risk Factors Related to Activities of Daily Living in Non-Dialysis Patients with Chronic Kidney Disease Stage 3–5: A Case–Control Study |
| description |
Jing Chang,* Wen-Wen Hou,* Yan-Fei Wang, Qian-Mei Sun Department of Internal Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qian-Mei Sun Email sunqianmei5825@126.comIntroduction: Elderly people are at increased risk of falls, disability and death due to reduced functional reserve, decline in multiple systems functions, which affects their activities of daily living (ADL) and eventually develop into frailty. The ADL assessment is conducive to early detection to avoid further serious situations. Previous studies on patients’ activities of daily living with chronic kidney disease (CKD) are mainly focused on dialysis patients. Little information is available on non-dialysis patients.Patients and Methods: A total of 303 elderly patients with CKD stage 3– 5 who were admitted to our hospital were selected. ADL evaluation was performed on patients at admission, with Barthel index (BI) as the evaluation tool. They were divided into two groups based on BI (≥ 60 and < 60). Demographic information, lifestyle and clinical profile were collected. The risk factors related to ADL were analyzed by univariate and multivariate models.Results: The data of 303 patients enrolled in this study were analyzed. The average age of patients was 84.48± 7.14 years and 62.05% were male. There were 88 patients (29.04%) in BI < 60 group and 215 patients (70.96%) in the BI ≥ 60 group. The average age of subjects in the two groups was 87.47 ± 5.85 years and 83.26± 7.28 years, respectively. On univariate analysis, ADL impairment was associated with many factors, such as age, body mass index, blood lipid, heart rate, smoking history, Charlson comorbidity index (CCI), hemoglobin, serum albumin, BNP, eGFR, etc. Multivariate logistic regression showed that age (OR 1.08, 95% CI 1.00– 1.17, P=0.0390), Charlson comorbidity index (OR 4.75, 95% CI 1.17– 19.30, P=0.0295), and serum albumin (OR 0.80, 95% CI 0.70– 0.92, P=0.0012) were the independent risk factors of ADL impairment.Conclusion: Decline of ADL in CKD patients was independently correlated with age, Charlson comorbidity index and serum albumin. ADL and its influential factors in the elderly CKD patients deserve further attention.Keywords: chronic kidney disease, activities of daily living, risk factors |
| format |
article |
| author |
Chang J Hou WW Wang YF Sun QM |
| author_facet |
Chang J Hou WW Wang YF Sun QM |
| author_sort |
Chang J |
| title |
Main Risk Factors Related to Activities of Daily Living in Non-Dialysis Patients with Chronic Kidney Disease Stage 3–5: A Case–Control Study |
| title_short |
Main Risk Factors Related to Activities of Daily Living in Non-Dialysis Patients with Chronic Kidney Disease Stage 3–5: A Case–Control Study |
| title_full |
Main Risk Factors Related to Activities of Daily Living in Non-Dialysis Patients with Chronic Kidney Disease Stage 3–5: A Case–Control Study |
| title_fullStr |
Main Risk Factors Related to Activities of Daily Living in Non-Dialysis Patients with Chronic Kidney Disease Stage 3–5: A Case–Control Study |
| title_full_unstemmed |
Main Risk Factors Related to Activities of Daily Living in Non-Dialysis Patients with Chronic Kidney Disease Stage 3–5: A Case–Control Study |
| title_sort |
main risk factors related to activities of daily living in non-dialysis patients with chronic kidney disease stage 3–5: a case–control study |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/72271aa85d8443739e3bbb799128f938 |
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