Dihydromyricetin affects BDNF levels in the nervous system in rats with comorbid diabetic neuropathic pain and depression

Abstract Diabetic neuropathic pain (DNP) and depression (DP) are the common complications in patients with diabetes. The purpose of our research was to observe whether brain-derived neurotrophic factor (BDNF) levels and tropomyosin receptor kinase B (TrkB) in the nervous system have effects on rats...

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Autores principales:	Huixiang Ge, Shu Guan, Yulin Shen, Mengyun Sun, Yuanzhen Hao, Lingkun He, Lijuan Liu, Cancan Yin, Ruoyu Huang, Wei Xiong, Yun Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/722a4f221d3243bd88cba99c98798e72
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spelling	oai:doaj.org-article:722a4f221d3243bd88cba99c98798e722021-12-02T15:08:59ZDihydromyricetin affects BDNF levels in the nervous system in rats with comorbid diabetic neuropathic pain and depression10.1038/s41598-019-51124-w2045-2322https://doaj.org/article/722a4f221d3243bd88cba99c98798e722019-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-51124-whttps://doaj.org/toc/2045-2322Abstract Diabetic neuropathic pain (DNP) and depression (DP) are the common complications in patients with diabetes. The purpose of our research was to observe whether brain-derived neurotrophic factor (BDNF) levels and tropomyosin receptor kinase B (TrkB) in the nervous system have effects on rats with comorbid DNP and DP, and to determine whether dihydromyricetin (DHM) may influence BDNF/ TrkB pathway to mitigatethe comorbidity. The study showed that DHM treatment could attenuates pain and depressive behavior in DNP and DP combined rats. Compared with the control group, the expression level of BDNF/TrkB in the hippocampus of DNP + DP group were reduced, while the expression levels in the spinal cord and DRG were increased. However, after treatment with DHM, those changes were reversed. Compared with the control group, the level of IL-1β and TNF-α in the hippocampus, spinal cord and DRG in the DNP + DP group was significantly increased, and DHM treatment could reduce the increase. Thus our study indicated that DHM can relief symptoms of DNP and DP by suppressing the BDNF/TrkB pathway and the proinflammatory factor, and BDNF/TrkB pathway may be an effective target for treatment of comorbid DNP and DP.Huixiang GeShu GuanYulin ShenMengyun SunYuanzhen HaoLingkun HeLijuan LiuCancan YinRuoyu HuangWei XiongYun GaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Huixiang Ge Shu Guan Yulin Shen Mengyun Sun Yuanzhen Hao Lingkun He Lijuan Liu Cancan Yin Ruoyu Huang Wei Xiong Yun Gao Dihydromyricetin affects BDNF levels in the nervous system in rats with comorbid diabetic neuropathic pain and depression
description	Abstract Diabetic neuropathic pain (DNP) and depression (DP) are the common complications in patients with diabetes. The purpose of our research was to observe whether brain-derived neurotrophic factor (BDNF) levels and tropomyosin receptor kinase B (TrkB) in the nervous system have effects on rats with comorbid DNP and DP, and to determine whether dihydromyricetin (DHM) may influence BDNF/ TrkB pathway to mitigatethe comorbidity. The study showed that DHM treatment could attenuates pain and depressive behavior in DNP and DP combined rats. Compared with the control group, the expression level of BDNF/TrkB in the hippocampus of DNP + DP group were reduced, while the expression levels in the spinal cord and DRG were increased. However, after treatment with DHM, those changes were reversed. Compared with the control group, the level of IL-1β and TNF-α in the hippocampus, spinal cord and DRG in the DNP + DP group was significantly increased, and DHM treatment could reduce the increase. Thus our study indicated that DHM can relief symptoms of DNP and DP by suppressing the BDNF/TrkB pathway and the proinflammatory factor, and BDNF/TrkB pathway may be an effective target for treatment of comorbid DNP and DP.
format	article
author	Huixiang Ge Shu Guan Yulin Shen Mengyun Sun Yuanzhen Hao Lingkun He Lijuan Liu Cancan Yin Ruoyu Huang Wei Xiong Yun Gao
author_facet	Huixiang Ge Shu Guan Yulin Shen Mengyun Sun Yuanzhen Hao Lingkun He Lijuan Liu Cancan Yin Ruoyu Huang Wei Xiong Yun Gao
author_sort	Huixiang Ge
title	Dihydromyricetin affects BDNF levels in the nervous system in rats with comorbid diabetic neuropathic pain and depression
title_short	Dihydromyricetin affects BDNF levels in the nervous system in rats with comorbid diabetic neuropathic pain and depression
title_full	Dihydromyricetin affects BDNF levels in the nervous system in rats with comorbid diabetic neuropathic pain and depression
title_fullStr	Dihydromyricetin affects BDNF levels in the nervous system in rats with comorbid diabetic neuropathic pain and depression
title_full_unstemmed	Dihydromyricetin affects BDNF levels in the nervous system in rats with comorbid diabetic neuropathic pain and depression
title_sort	dihydromyricetin affects bdnf levels in the nervous system in rats with comorbid diabetic neuropathic pain and depression
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/722a4f221d3243bd88cba99c98798e72
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Dihydromyricetin affects BDNF levels in the nervous system in rats with comorbid diabetic neuropathic pain and depression

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