Profile of Obesity and Comorbidities in Elderly Patients with Heart Failure

Alexandra Dădârlat-Pop,1 Adela Sitar-Tăut,2 Dumitru Zdrenghea,3 Bogdan Caloian,3 Raluca Tomoaia,1 Dana Pop,3 Anca Buzoianu4 1Cardiology Department, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; 2Internal Medicine Department, 2nd Department, Medical...

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Autores principales:	Dădârlat-Pop A, Sitar-Tăut A, Zdrenghea D, Caloian B, Tomoaia R, Pop D, Buzoianu A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	obesity heart failure comorbidity elderly patients Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/722b5c8e23d7451b86f4b0a74b60231c
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spelling	oai:doaj.org-article:722b5c8e23d7451b86f4b0a74b60231c2021-12-02T09:00:52ZProfile of Obesity and Comorbidities in Elderly Patients with Heart Failure1178-1998https://doaj.org/article/722b5c8e23d7451b86f4b0a74b60231c2020-04-01T00:00:00Zhttps://www.dovepress.com/profile-of-obesity-and-comorbidities-in-elderly-patients-with-heart-fa-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Alexandra Dădârlat-Pop,1 Adela Sitar-Tăut,2 Dumitru Zdrenghea,3 Bogdan Caloian,3 Raluca Tomoaia,1 Dana Pop,3 Anca Buzoianu4 1Cardiology Department, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; 2Internal Medicine Department, 2nd Department, Medical Clinic IV, Cluj-Napoca, Romania; 3Internal Medicine Department, Cardiology - Rehabilitation Department, Clinical Rehabilitation Hospital, Cluj-Napoca, Romania; 4Department of Pharmacology, Toxicology and Clinical Pharmacology, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, RomaniaCorrespondence: Dana Pop Email pop67dana@gmail.comBackground and Purpose: In Romania, robust data about the prevalence of obesity and heart failure are lacking, especially in the elderly; therefore, this study aims to analyze the profile of overweight and obese patients aged > 65 years admitted to a Romanian hospital for worsening heart failure, and also their risk in the presence of comorbidities.Patients and Methods: This cross-sectional study was conducted in 126 consecutive elderly patients with overweight and obesity admitted to a Romanian hospital for worsening heart failure. They were divided into three groups: with reduced (< 40%) – HFrEF, mid-range (40– 49%) – HFmrEF and preserved (≥ 50%) ejection fraction – HFpEF. Obesity was defined according to the body mass index (BMI) status: obesity, ≥ 30 kg/m2; overweight, 25– 29.9 kg/m2. The Charlson Comorbidity Index (CCI) was calculated to evaluate the severity of comorbidity, with a score ranging from 2 (only heart failure present and age > 65 years) to 30 (extensive comorbidity).Results: NT-proBNP values are negatively correlated with BMI only in patients with HFpEF. Creatinine clearance (p=0.0166), the presence of atrial fibrillation (p=0.0095) and NYHA functional class were independent predictors of increased NT-proBNP values. CCI score is negatively correlated with NT-proBNP values in patients with HFmrEF (r= − 0.448, p=0.009) and HFpEF (r= − 0.273, p=0.043). The CCI risk was not significantly different between the three groups.Conclusion: Elderly heart failure patients with overweight or obesity have particular characteristics in terms of NT-proBNP values and presence of comorbidities. In the studied population, NT-proBNP levels were strongly influenced by renal function, NYHA functional class, the presence of atrial fibrillation and left ventricular ejection fraction.Keywords: obesity, heart failure, comorbidity, elderly patientsDădârlat-Pop ASitar-Tăut AZdrenghea DCaloian BTomoaia RPop DBuzoianu ADove Medical Pressarticleobesityheart failurecomorbidityelderly patientsGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 15, Pp 547-556 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity heart failure comorbidity elderly patients Geriatrics RC952-954.6
spellingShingle	obesity heart failure comorbidity elderly patients Geriatrics RC952-954.6 Dădârlat-Pop A Sitar-Tăut A Zdrenghea D Caloian B Tomoaia R Pop D Buzoianu A Profile of Obesity and Comorbidities in Elderly Patients with Heart Failure
description	Alexandra Dădârlat-Pop,1 Adela Sitar-Tăut,2 Dumitru Zdrenghea,3 Bogdan Caloian,3 Raluca Tomoaia,1 Dana Pop,3 Anca Buzoianu4 1Cardiology Department, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; 2Internal Medicine Department, 2nd Department, Medical Clinic IV, Cluj-Napoca, Romania; 3Internal Medicine Department, Cardiology - Rehabilitation Department, Clinical Rehabilitation Hospital, Cluj-Napoca, Romania; 4Department of Pharmacology, Toxicology and Clinical Pharmacology, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, RomaniaCorrespondence: Dana Pop Email pop67dana@gmail.comBackground and Purpose: In Romania, robust data about the prevalence of obesity and heart failure are lacking, especially in the elderly; therefore, this study aims to analyze the profile of overweight and obese patients aged > 65 years admitted to a Romanian hospital for worsening heart failure, and also their risk in the presence of comorbidities.Patients and Methods: This cross-sectional study was conducted in 126 consecutive elderly patients with overweight and obesity admitted to a Romanian hospital for worsening heart failure. They were divided into three groups: with reduced (< 40%) – HFrEF, mid-range (40– 49%) – HFmrEF and preserved (≥ 50%) ejection fraction – HFpEF. Obesity was defined according to the body mass index (BMI) status: obesity, ≥ 30 kg/m2; overweight, 25– 29.9 kg/m2. The Charlson Comorbidity Index (CCI) was calculated to evaluate the severity of comorbidity, with a score ranging from 2 (only heart failure present and age > 65 years) to 30 (extensive comorbidity).Results: NT-proBNP values are negatively correlated with BMI only in patients with HFpEF. Creatinine clearance (p=0.0166), the presence of atrial fibrillation (p=0.0095) and NYHA functional class were independent predictors of increased NT-proBNP values. CCI score is negatively correlated with NT-proBNP values in patients with HFmrEF (r= − 0.448, p=0.009) and HFpEF (r= − 0.273, p=0.043). The CCI risk was not significantly different between the three groups.Conclusion: Elderly heart failure patients with overweight or obesity have particular characteristics in terms of NT-proBNP values and presence of comorbidities. In the studied population, NT-proBNP levels were strongly influenced by renal function, NYHA functional class, the presence of atrial fibrillation and left ventricular ejection fraction.Keywords: obesity, heart failure, comorbidity, elderly patients
format	article
author	Dădârlat-Pop A Sitar-Tăut A Zdrenghea D Caloian B Tomoaia R Pop D Buzoianu A
author_facet	Dădârlat-Pop A Sitar-Tăut A Zdrenghea D Caloian B Tomoaia R Pop D Buzoianu A
author_sort	Dădârlat-Pop A
title	Profile of Obesity and Comorbidities in Elderly Patients with Heart Failure
title_short	Profile of Obesity and Comorbidities in Elderly Patients with Heart Failure
title_full	Profile of Obesity and Comorbidities in Elderly Patients with Heart Failure
title_fullStr	Profile of Obesity and Comorbidities in Elderly Patients with Heart Failure
title_full_unstemmed	Profile of Obesity and Comorbidities in Elderly Patients with Heart Failure
title_sort	profile of obesity and comorbidities in elderly patients with heart failure
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/722b5c8e23d7451b86f4b0a74b60231c
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Profile of Obesity and Comorbidities in Elderly Patients with Heart Failure

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