Carbon nanoparticle suspension could help get a more accurate nodal staging for patient with rectal cancer

Abstract This study aimed to evaluate whether carbon nanoparticles could improve the accuracy of nodal staging in colorectal cancer (CRC). We performed a randomized controlled trial with CRC at the department of general surgery, the affiliated hospital of Nanjing University Medical School. A total o...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wei Ge, Qiang Li, Wen-jia Liu, Xiao-Qi Zhang, Xiang-shan Fan, Li-hua Shao, Liang Tao, Wen-xian Guan, Gang Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/722d14e6797f458eadb2c416be328570
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:722d14e6797f458eadb2c416be328570
record_format	dspace
spelling	oai:doaj.org-article:722d14e6797f458eadb2c416be3285702021-12-02T14:35:47ZCarbon nanoparticle suspension could help get a more accurate nodal staging for patient with rectal cancer10.1038/s41598-021-89541-52045-2322https://doaj.org/article/722d14e6797f458eadb2c416be3285702021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89541-5https://doaj.org/toc/2045-2322Abstract This study aimed to evaluate whether carbon nanoparticles could improve the accuracy of nodal staging in colorectal cancer (CRC). We performed a randomized controlled trial with CRC at the department of general surgery, the affiliated hospital of Nanjing University Medical School. A total of 160 patients were recruited in this research and 132 patients were included in the safety analyses. Among these patients, 72 cases were classified into control group and 60 cases into study group. The mean number of lymph nodes harvested from patients in study group was 19.3 ± 6.7 (range from 4 to 38), which was higher than that in control group (15.1 ± 5.7 (range from 3 to 29)) (p < 0.001). The mean number of positive lymph nodes got from patients in study group was 1.7 ± 3.5 (range from 0 to 22), which was also higher than that in control group (0.7 ± 1.4 (range from 0 to 7)) (p = 0.045). In study group, there were 30 patients (50%) proved to be N0, and remaining 30 patients (50%) were N1 or N2. However, 50 patients (69.4%) were N0 and 22 patients (30.6%) were N1 or N2 in control group. The rate of N0 in control group was significantly higher than that in study group (p = 0.023). Injecting carbon nanoparticle suspension could get a more accurate nodal staging to receive enough chemoradiotherapy, improving prognosis. Besides, injecting carbon nanoparticles suspension at four points 5 cm, 10 cm, 15 cm and 20 cm away from the anus by “sandwich” method was a new try. Trial registration: This study was registered with ClinicalTrials.gov, number ChiCTR1900025127 on 12/8/2019.Wei GeQiang LiWen-jia LiuXiao-Qi ZhangXiang-shan FanLi-hua ShaoLiang TaoWen-xian GuanGang ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wei Ge Qiang Li Wen-jia Liu Xiao-Qi Zhang Xiang-shan Fan Li-hua Shao Liang Tao Wen-xian Guan Gang Chen Carbon nanoparticle suspension could help get a more accurate nodal staging for patient with rectal cancer
description	Abstract This study aimed to evaluate whether carbon nanoparticles could improve the accuracy of nodal staging in colorectal cancer (CRC). We performed a randomized controlled trial with CRC at the department of general surgery, the affiliated hospital of Nanjing University Medical School. A total of 160 patients were recruited in this research and 132 patients were included in the safety analyses. Among these patients, 72 cases were classified into control group and 60 cases into study group. The mean number of lymph nodes harvested from patients in study group was 19.3 ± 6.7 (range from 4 to 38), which was higher than that in control group (15.1 ± 5.7 (range from 3 to 29)) (p < 0.001). The mean number of positive lymph nodes got from patients in study group was 1.7 ± 3.5 (range from 0 to 22), which was also higher than that in control group (0.7 ± 1.4 (range from 0 to 7)) (p = 0.045). In study group, there were 30 patients (50%) proved to be N0, and remaining 30 patients (50%) were N1 or N2. However, 50 patients (69.4%) were N0 and 22 patients (30.6%) were N1 or N2 in control group. The rate of N0 in control group was significantly higher than that in study group (p = 0.023). Injecting carbon nanoparticle suspension could get a more accurate nodal staging to receive enough chemoradiotherapy, improving prognosis. Besides, injecting carbon nanoparticles suspension at four points 5 cm, 10 cm, 15 cm and 20 cm away from the anus by “sandwich” method was a new try. Trial registration: This study was registered with ClinicalTrials.gov, number ChiCTR1900025127 on 12/8/2019.
format	article
author	Wei Ge Qiang Li Wen-jia Liu Xiao-Qi Zhang Xiang-shan Fan Li-hua Shao Liang Tao Wen-xian Guan Gang Chen
author_facet	Wei Ge Qiang Li Wen-jia Liu Xiao-Qi Zhang Xiang-shan Fan Li-hua Shao Liang Tao Wen-xian Guan Gang Chen
author_sort	Wei Ge
title	Carbon nanoparticle suspension could help get a more accurate nodal staging for patient with rectal cancer
title_short	Carbon nanoparticle suspension could help get a more accurate nodal staging for patient with rectal cancer
title_full	Carbon nanoparticle suspension could help get a more accurate nodal staging for patient with rectal cancer
title_fullStr	Carbon nanoparticle suspension could help get a more accurate nodal staging for patient with rectal cancer
title_full_unstemmed	Carbon nanoparticle suspension could help get a more accurate nodal staging for patient with rectal cancer
title_sort	carbon nanoparticle suspension could help get a more accurate nodal staging for patient with rectal cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/722d14e6797f458eadb2c416be328570
work_keys_str_mv	AT weige carbonnanoparticlesuspensioncouldhelpgetamoreaccuratenodalstagingforpatientwithrectalcancer AT qiangli carbonnanoparticlesuspensioncouldhelpgetamoreaccuratenodalstagingforpatientwithrectalcancer AT wenjialiu carbonnanoparticlesuspensioncouldhelpgetamoreaccuratenodalstagingforpatientwithrectalcancer AT xiaoqizhang carbonnanoparticlesuspensioncouldhelpgetamoreaccuratenodalstagingforpatientwithrectalcancer AT xiangshanfan carbonnanoparticlesuspensioncouldhelpgetamoreaccuratenodalstagingforpatientwithrectalcancer AT lihuashao carbonnanoparticlesuspensioncouldhelpgetamoreaccuratenodalstagingforpatientwithrectalcancer AT liangtao carbonnanoparticlesuspensioncouldhelpgetamoreaccuratenodalstagingforpatientwithrectalcancer AT wenxianguan carbonnanoparticlesuspensioncouldhelpgetamoreaccuratenodalstagingforpatientwithrectalcancer AT gangchen carbonnanoparticlesuspensioncouldhelpgetamoreaccuratenodalstagingforpatientwithrectalcancer
_version_	1718391079310458880

Carbon nanoparticle suspension could help get a more accurate nodal staging for patient with rectal cancer

Ejemplares similares