Sortilin limits EGFR signaling by promoting its internalization in lung cancer

Sortilin limits EGFR signaling by promoting its internalization in lung cancer

Disruptions in epidermal growth factor receptor (EGFR) trafficking has been linked to tumor progression. Here the authors show that sortilin limits cell proliferation and tumor growth by promoting EGFR internalization.

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Autores principales: Hussein Al-Akhrass, Thomas Naves, François Vincent, Amandine Magnaudeix, Karine Durand, François Bertin, Boris Melloni, Marie-Odile Jauberteau, Fabrice Lalloué
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/722e02c5061e4c01af173af761d7e04f
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spelling oai:doaj.org-article:722e02c5061e4c01af173af761d7e04f2021-12-02T14:42:37ZSortilin limits EGFR signaling by promoting its internalization in lung cancer10.1038/s41467-017-01172-52041-1723https://doaj.org/article/722e02c5061e4c01af173af761d7e04f2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01172-5https://doaj.org/toc/2041-1723Disruptions in epidermal growth factor receptor (EGFR) trafficking has been linked to tumor progression. Here the authors show that sortilin limits cell proliferation and tumor growth by promoting EGFR internalization.Hussein Al-AkhrassThomas NavesFrançois VincentAmandine MagnaudeixKarine DurandFrançois BertinBoris MelloniMarie-Odile JauberteauFabrice LallouéNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hussein Al-Akhrass
Thomas Naves
François Vincent
Amandine Magnaudeix
Karine Durand
François Bertin
Boris Melloni
Marie-Odile Jauberteau
Fabrice Lalloué
Sortilin limits EGFR signaling by promoting its internalization in lung cancer
description Disruptions in epidermal growth factor receptor (EGFR) trafficking has been linked to tumor progression. Here the authors show that sortilin limits cell proliferation and tumor growth by promoting EGFR internalization.
format article
author Hussein Al-Akhrass
Thomas Naves
François Vincent
Amandine Magnaudeix
Karine Durand
François Bertin
Boris Melloni
Marie-Odile Jauberteau
Fabrice Lalloué
author_facet Hussein Al-Akhrass
Thomas Naves
François Vincent
Amandine Magnaudeix
Karine Durand
François Bertin
Boris Melloni
Marie-Odile Jauberteau
Fabrice Lalloué
author_sort Hussein Al-Akhrass
title Sortilin limits EGFR signaling by promoting its internalization in lung cancer
title_short Sortilin limits EGFR signaling by promoting its internalization in lung cancer
title_full Sortilin limits EGFR signaling by promoting its internalization in lung cancer
title_fullStr Sortilin limits EGFR signaling by promoting its internalization in lung cancer
title_full_unstemmed Sortilin limits EGFR signaling by promoting its internalization in lung cancer
title_sort sortilin limits egfr signaling by promoting its internalization in lung cancer
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/722e02c5061e4c01af173af761d7e04f
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AT francoisvincent sortilinlimitsegfrsignalingbypromotingitsinternalizationinlungcancer
AT amandinemagnaudeix sortilinlimitsegfrsignalingbypromotingitsinternalizationinlungcancer
AT karinedurand sortilinlimitsegfrsignalingbypromotingitsinternalizationinlungcancer
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