Sortilin limits EGFR signaling by promoting its internalization in lung cancer

Sortilin limits EGFR signaling by promoting its internalization in lung cancer

Disruptions in epidermal growth factor receptor (EGFR) trafficking has been linked to tumor progression. Here the authors show that sortilin limits cell proliferation and tumor growth by promoting EGFR internalization.

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Detalles Bibliográficos
Autores principales: Hussein Al-Akhrass, Thomas Naves, François Vincent, Amandine Magnaudeix, Karine Durand, François Bertin, Boris Melloni, Marie-Odile Jauberteau, Fabrice Lalloué
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/722e02c5061e4c01af173af761d7e04f
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