Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate

Invasion of the adipose tissue correlates with poor prognosis in breast cancer. Here, the authors show that mammary gland adipocytes promote malignancy via β-hydroxybutyrate, which acts on cancer cells through the monocarboxylate transporter MCT2 resulting in tumour-promoting epigenetic modification...

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Auteurs principaux:	Chun-Kai Huang, Po-Hao Chang, Wen-Hung Kuo, Chi-Long Chen, Yung-Ming Jeng, King-Jen Chang, Jin-Yuh Shew, Chun-Mei Hu, Wen-Hwa Lee
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/722e51da423e4a8a8df28fb9227a5890
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spelling	oai:doaj.org-article:722e51da423e4a8a8df28fb9227a58902021-12-02T17:06:13ZAdipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate10.1038/ncomms147062041-1723https://doaj.org/article/722e51da423e4a8a8df28fb9227a58902017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14706https://doaj.org/toc/2041-1723Invasion of the adipose tissue correlates with poor prognosis in breast cancer. Here, the authors show that mammary gland adipocytes promote malignancy via β-hydroxybutyrate, which acts on cancer cells through the monocarboxylate transporter MCT2 resulting in tumour-promoting epigenetic modifications.Chun-Kai HuangPo-Hao ChangWen-Hung KuoChi-Long ChenYung-Ming JengKing-Jen ChangJin-Yuh ShewChun-Mei HuWen-Hwa LeeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chun-Kai Huang Po-Hao Chang Wen-Hung Kuo Chi-Long Chen Yung-Ming Jeng King-Jen Chang Jin-Yuh Shew Chun-Mei Hu Wen-Hwa Lee Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate
description	Invasion of the adipose tissue correlates with poor prognosis in breast cancer. Here, the authors show that mammary gland adipocytes promote malignancy via β-hydroxybutyrate, which acts on cancer cells through the monocarboxylate transporter MCT2 resulting in tumour-promoting epigenetic modifications.
format	article
author	Chun-Kai Huang Po-Hao Chang Wen-Hung Kuo Chi-Long Chen Yung-Ming Jeng King-Jen Chang Jin-Yuh Shew Chun-Mei Hu Wen-Hwa Lee
author_facet	Chun-Kai Huang Po-Hao Chang Wen-Hung Kuo Chi-Long Chen Yung-Ming Jeng King-Jen Chang Jin-Yuh Shew Chun-Mei Hu Wen-Hwa Lee
author_sort	Chun-Kai Huang
title	Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate
title_short	Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate
title_full	Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate
title_fullStr	Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate
title_full_unstemmed	Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate
title_sort	adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/722e51da423e4a8a8df28fb9227a5890
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Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate

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