Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes

Myelodysplastic syndrome (MDS) arises from mutations in hematopoietic stem cells (HSCs). Here, the authors demonstrate that HSCs in higher-risk MDS express the surface marker CD123 and are characterized by activation of protein synthesis machinery and increased oxidative phosphorylation.

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Autores principales:	Brett M. Stevens, Nabilah Khan, Angelo D’Alessandro, Travis Nemkov, Amanda Winters, Courtney L. Jones, Wei Zhang, Daniel A. Pollyea, Craig T. Jordan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7232188cb74f401c89e6e1606e8171e9
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spelling	oai:doaj.org-article:7232188cb74f401c89e6e1606e8171e92021-12-02T16:50:05ZCharacterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes10.1038/s41467-018-05984-x2041-1723https://doaj.org/article/7232188cb74f401c89e6e1606e8171e92018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05984-xhttps://doaj.org/toc/2041-1723Myelodysplastic syndrome (MDS) arises from mutations in hematopoietic stem cells (HSCs). Here, the authors demonstrate that HSCs in higher-risk MDS express the surface marker CD123 and are characterized by activation of protein synthesis machinery and increased oxidative phosphorylation.Brett M. StevensNabilah KhanAngelo D’AlessandroTravis NemkovAmanda WintersCourtney L. JonesWei ZhangDaniel A. PollyeaCraig T. JordanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brett M. Stevens Nabilah Khan Angelo D’Alessandro Travis Nemkov Amanda Winters Courtney L. Jones Wei Zhang Daniel A. Pollyea Craig T. Jordan Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes
description	Myelodysplastic syndrome (MDS) arises from mutations in hematopoietic stem cells (HSCs). Here, the authors demonstrate that HSCs in higher-risk MDS express the surface marker CD123 and are characterized by activation of protein synthesis machinery and increased oxidative phosphorylation.
format	article
author	Brett M. Stevens Nabilah Khan Angelo D’Alessandro Travis Nemkov Amanda Winters Courtney L. Jones Wei Zhang Daniel A. Pollyea Craig T. Jordan
author_facet	Brett M. Stevens Nabilah Khan Angelo D’Alessandro Travis Nemkov Amanda Winters Courtney L. Jones Wei Zhang Daniel A. Pollyea Craig T. Jordan
author_sort	Brett M. Stevens
title	Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes
title_short	Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes
title_full	Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes
title_fullStr	Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes
title_full_unstemmed	Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes
title_sort	characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7232188cb74f401c89e6e1606e8171e9
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Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes

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