Rapid review of multisystem inflammatory syndrome in paediatrics: What we know one year later

Background: Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19) is an emerging condition that was first identified in paediatrics at the onset of the COVID-19 pandemic. The condition is also known as pediatric inflammatory multisystem syndrome te...

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Autores principales:	Megan Striha, Rojiemiahd Edjoc, Natalie Bresee, Nicole Atchessi, Lisa Waddell, Terri-Lyn Bennett, Emily Thompson, Maryem El Jaouhari, Samuel Bonti-Ankomah
Formato:	article
Lenguaje:	EN FR
Publicado:	Public Health Agency of Canada 2021
Materias:	multisystem inflammatory syndrome in children pediatric multisystem inflammatory syndrome covid-19 mis-c pims pims-ts Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/72364b68b8f34018b3505fe3db5547d5
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spelling	oai:doaj.org-article:72364b68b8f34018b3505fe3db5547d52021-11-18T19:53:13ZRapid review of multisystem inflammatory syndrome in paediatrics: What we know one year later10.14745/ccdr.v47i11a041481-8531https://doaj.org/article/72364b68b8f34018b3505fe3db5547d52021-11-01T00:00:00Zhttps://www.canada.ca/en/public-health/services/reports-publications/canada-communicable-disease-report-ccdr/monthly-issue/2021-47/issue-11-november-2021/rapid-review-multisystem-inflammatory-syndrome-paediatrics-canada.htmlhttps://doaj.org/toc/1481-8531Background: Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19) is an emerging condition that was first identified in paediatrics at the onset of the COVID-19 pandemic. The condition is also known as pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (PIMS-TS or PIMS), and multiple definitions have been established for this condition that share overlapping features with Kawasaki Disease and toxic shock syndrome. Methods: A review was conducted to identify literature describing the epidemiology of MIS-C, published up until March 9, 2021. A database established at the Public Health Agency of Canada with COVID-19 literature was searched for articles referencing MIS-C, PIMS or Kawasaki Disease in relation to COVID-19. Results: A total of 195 out of 988 articles were included in the review. The median age of MIS-C patients was between seven and 10 years of age, although children of all ages (and adults) can be affected. Multisystem inflammatory syndrome in children disproportionately affected males (58% patients), and Black and Hispanic children seem to be at an elevated risk for developing MIS-C. Roughly 62% of MIS-C patients required admission to an intensive care unit, with one in five patients requiring mechanical ventilation. Between 0% and 2% of MIS-C patients died, depending on the population and available interventions. Conclusion: Multisystem inflammatory syndrome in children can affect children of all ages. A significant proportion of patients required intensive care unit and mechanical ventilation and 0%–2% of cases resulted in fatalities. More evidence is needed on the role of race, ethnicity and comorbidities in the development of MIS-C.Megan StrihaRojiemiahd EdjocNatalie BreseeNicole AtchessiLisa WaddellTerri-Lyn BennettEmily ThompsonMaryem El Jaouhari Samuel Bonti-AnkomahPublic Health Agency of Canadaarticlemultisystem inflammatory syndrome in childrenpediatric multisystem inflammatory syndromecovid-19mis-cpimspims-tsInfectious and parasitic diseasesRC109-216ENFRCanada Communicable Disease Report , Vol 47, Iss 11, Pp 466-472 (2021)
institution	DOAJ
collection	DOAJ
language	EN FR
topic	multisystem inflammatory syndrome in children pediatric multisystem inflammatory syndrome covid-19 mis-c pims pims-ts Infectious and parasitic diseases RC109-216
spellingShingle	multisystem inflammatory syndrome in children pediatric multisystem inflammatory syndrome covid-19 mis-c pims pims-ts Infectious and parasitic diseases RC109-216 Megan Striha Rojiemiahd Edjoc Natalie Bresee Nicole Atchessi Lisa Waddell Terri-Lyn Bennett Emily Thompson Maryem El Jaouhari Samuel Bonti-Ankomah Rapid review of multisystem inflammatory syndrome in paediatrics: What we know one year later
description	Background: Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19) is an emerging condition that was first identified in paediatrics at the onset of the COVID-19 pandemic. The condition is also known as pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (PIMS-TS or PIMS), and multiple definitions have been established for this condition that share overlapping features with Kawasaki Disease and toxic shock syndrome. Methods: A review was conducted to identify literature describing the epidemiology of MIS-C, published up until March 9, 2021. A database established at the Public Health Agency of Canada with COVID-19 literature was searched for articles referencing MIS-C, PIMS or Kawasaki Disease in relation to COVID-19. Results: A total of 195 out of 988 articles were included in the review. The median age of MIS-C patients was between seven and 10 years of age, although children of all ages (and adults) can be affected. Multisystem inflammatory syndrome in children disproportionately affected males (58% patients), and Black and Hispanic children seem to be at an elevated risk for developing MIS-C. Roughly 62% of MIS-C patients required admission to an intensive care unit, with one in five patients requiring mechanical ventilation. Between 0% and 2% of MIS-C patients died, depending on the population and available interventions. Conclusion: Multisystem inflammatory syndrome in children can affect children of all ages. A significant proportion of patients required intensive care unit and mechanical ventilation and 0%–2% of cases resulted in fatalities. More evidence is needed on the role of race, ethnicity and comorbidities in the development of MIS-C.
format	article
author	Megan Striha Rojiemiahd Edjoc Natalie Bresee Nicole Atchessi Lisa Waddell Terri-Lyn Bennett Emily Thompson Maryem El Jaouhari Samuel Bonti-Ankomah
author_facet	Megan Striha Rojiemiahd Edjoc Natalie Bresee Nicole Atchessi Lisa Waddell Terri-Lyn Bennett Emily Thompson Maryem El Jaouhari Samuel Bonti-Ankomah
author_sort	Megan Striha
title	Rapid review of multisystem inflammatory syndrome in paediatrics: What we know one year later
title_short	Rapid review of multisystem inflammatory syndrome in paediatrics: What we know one year later
title_full	Rapid review of multisystem inflammatory syndrome in paediatrics: What we know one year later
title_fullStr	Rapid review of multisystem inflammatory syndrome in paediatrics: What we know one year later
title_full_unstemmed	Rapid review of multisystem inflammatory syndrome in paediatrics: What we know one year later
title_sort	rapid review of multisystem inflammatory syndrome in paediatrics: what we know one year later
publisher	Public Health Agency of Canada
publishDate	2021
url	https://doaj.org/article/72364b68b8f34018b3505fe3db5547d5
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Rapid review of multisystem inflammatory syndrome in paediatrics: What we know one year later

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