Racial, ethnic, and gender differences in obesity and body fat distribution: An All of Us Research Program demonstration project.
Differences in obesity and body fat distribution across gender and race/ethnicity have been extensively described. We sought to replicate these differences and evaluate newly emerging data from the All of Us Research Program (AoU). We compared body mass index (BMI), waist circumference, and waist-to...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/7239c6ad194f4ca99d274e683234be27 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:7239c6ad194f4ca99d274e683234be27 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:7239c6ad194f4ca99d274e683234be272021-12-02T20:18:32ZRacial, ethnic, and gender differences in obesity and body fat distribution: An All of Us Research Program demonstration project.1932-620310.1371/journal.pone.0255583https://doaj.org/article/7239c6ad194f4ca99d274e683234be272021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255583https://doaj.org/toc/1932-6203Differences in obesity and body fat distribution across gender and race/ethnicity have been extensively described. We sought to replicate these differences and evaluate newly emerging data from the All of Us Research Program (AoU). We compared body mass index (BMI), waist circumference, and waist-to-hip ratio from the baseline physical examination, and alanine aminotransferase (ALT) from the electronic health record in up to 88,195 Non-Hispanic White (NHW), 40,770 Non-Hispanic Black (NHB), 35,640 Hispanic, and 5,648 Asian participants. We compared AoU sociodemographic variable distribution to National Health and Nutrition Examination Survey (NHANES) data and applied the pseudo-weighting method for adjusting selection biases of AoU recruitment. Our findings replicate previous observations with respect to gender differences in BMI. In particular, we replicate the large gender disparity in obesity rates among NHB participants, in which obesity and mean BMI are much higher in NHB women than NHB men (33.34 kg/m2 versus 28.40 kg/m2 respectively; p<2.22x10-308). The overall age-adjusted obesity prevalence in AoU participants is similar overall but lower than the prevalence found in NHANES for NHW participants. ALT was higher in men than women, and lower among NHB participants compared to other racial/ethnic groups, consistent with previous findings. Our data suggest consistency of AoU with national averages related to obesity and suggest this resource is likely to be a major source of scientific inquiry and discovery in diverse populations.Jason H KarnesAmit AroraJianglin FengHeidi E SteinerLina SuliemanEric BoerwinkleCheryl ClarkMine CicekElizabeth CohnKelly GeboRoxana Loperena-CortesLucila Ohno-MachadoKelsey MayoSteve MockrinAndrea RamirezSheri SchullyYann C KlimentidisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255583 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Jason H Karnes Amit Arora Jianglin Feng Heidi E Steiner Lina Sulieman Eric Boerwinkle Cheryl Clark Mine Cicek Elizabeth Cohn Kelly Gebo Roxana Loperena-Cortes Lucila Ohno-Machado Kelsey Mayo Steve Mockrin Andrea Ramirez Sheri Schully Yann C Klimentidis Racial, ethnic, and gender differences in obesity and body fat distribution: An All of Us Research Program demonstration project. |
| description |
Differences in obesity and body fat distribution across gender and race/ethnicity have been extensively described. We sought to replicate these differences and evaluate newly emerging data from the All of Us Research Program (AoU). We compared body mass index (BMI), waist circumference, and waist-to-hip ratio from the baseline physical examination, and alanine aminotransferase (ALT) from the electronic health record in up to 88,195 Non-Hispanic White (NHW), 40,770 Non-Hispanic Black (NHB), 35,640 Hispanic, and 5,648 Asian participants. We compared AoU sociodemographic variable distribution to National Health and Nutrition Examination Survey (NHANES) data and applied the pseudo-weighting method for adjusting selection biases of AoU recruitment. Our findings replicate previous observations with respect to gender differences in BMI. In particular, we replicate the large gender disparity in obesity rates among NHB participants, in which obesity and mean BMI are much higher in NHB women than NHB men (33.34 kg/m2 versus 28.40 kg/m2 respectively; p<2.22x10-308). The overall age-adjusted obesity prevalence in AoU participants is similar overall but lower than the prevalence found in NHANES for NHW participants. ALT was higher in men than women, and lower among NHB participants compared to other racial/ethnic groups, consistent with previous findings. Our data suggest consistency of AoU with national averages related to obesity and suggest this resource is likely to be a major source of scientific inquiry and discovery in diverse populations. |
| format |
article |
| author |
Jason H Karnes Amit Arora Jianglin Feng Heidi E Steiner Lina Sulieman Eric Boerwinkle Cheryl Clark Mine Cicek Elizabeth Cohn Kelly Gebo Roxana Loperena-Cortes Lucila Ohno-Machado Kelsey Mayo Steve Mockrin Andrea Ramirez Sheri Schully Yann C Klimentidis |
| author_facet |
Jason H Karnes Amit Arora Jianglin Feng Heidi E Steiner Lina Sulieman Eric Boerwinkle Cheryl Clark Mine Cicek Elizabeth Cohn Kelly Gebo Roxana Loperena-Cortes Lucila Ohno-Machado Kelsey Mayo Steve Mockrin Andrea Ramirez Sheri Schully Yann C Klimentidis |
| author_sort |
Jason H Karnes |
| title |
Racial, ethnic, and gender differences in obesity and body fat distribution: An All of Us Research Program demonstration project. |
| title_short |
Racial, ethnic, and gender differences in obesity and body fat distribution: An All of Us Research Program demonstration project. |
| title_full |
Racial, ethnic, and gender differences in obesity and body fat distribution: An All of Us Research Program demonstration project. |
| title_fullStr |
Racial, ethnic, and gender differences in obesity and body fat distribution: An All of Us Research Program demonstration project. |
| title_full_unstemmed |
Racial, ethnic, and gender differences in obesity and body fat distribution: An All of Us Research Program demonstration project. |
| title_sort |
racial, ethnic, and gender differences in obesity and body fat distribution: an all of us research program demonstration project. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/7239c6ad194f4ca99d274e683234be27 |
| work_keys_str_mv |
AT jasonhkarnes racialethnicandgenderdifferencesinobesityandbodyfatdistributionanallofusresearchprogramdemonstrationproject AT amitarora racialethnicandgenderdifferencesinobesityandbodyfatdistributionanallofusresearchprogramdemonstrationproject AT jianglinfeng racialethnicandgenderdifferencesinobesityandbodyfatdistributionanallofusresearchprogramdemonstrationproject AT heidiesteiner racialethnicandgenderdifferencesinobesityandbodyfatdistributionanallofusresearchprogramdemonstrationproject AT linasulieman racialethnicandgenderdifferencesinobesityandbodyfatdistributionanallofusresearchprogramdemonstrationproject AT ericboerwinkle racialethnicandgenderdifferencesinobesityandbodyfatdistributionanallofusresearchprogramdemonstrationproject AT cherylclark racialethnicandgenderdifferencesinobesityandbodyfatdistributionanallofusresearchprogramdemonstrationproject AT minecicek racialethnicandgenderdifferencesinobesityandbodyfatdistributionanallofusresearchprogramdemonstrationproject AT elizabethcohn racialethnicandgenderdifferencesinobesityandbodyfatdistributionanallofusresearchprogramdemonstrationproject AT kellygebo racialethnicandgenderdifferencesinobesityandbodyfatdistributionanallofusresearchprogramdemonstrationproject AT roxanaloperenacortes racialethnicandgenderdifferencesinobesityandbodyfatdistributionanallofusresearchprogramdemonstrationproject AT lucilaohnomachado racialethnicandgenderdifferencesinobesityandbodyfatdistributionanallofusresearchprogramdemonstrationproject AT kelseymayo racialethnicandgenderdifferencesinobesityandbodyfatdistributionanallofusresearchprogramdemonstrationproject AT stevemockrin racialethnicandgenderdifferencesinobesityandbodyfatdistributionanallofusresearchprogramdemonstrationproject AT andrearamirez racialethnicandgenderdifferencesinobesityandbodyfatdistributionanallofusresearchprogramdemonstrationproject AT sherischully racialethnicandgenderdifferencesinobesityandbodyfatdistributionanallofusresearchprogramdemonstrationproject AT yanncklimentidis racialethnicandgenderdifferencesinobesityandbodyfatdistributionanallofusresearchprogramdemonstrationproject |
| _version_ |
1718374290713214976 |