The 2-Year Leakage Index and Quantitative Microaneurysm Results of the RECOVERY Study: Quantitative Ultra-Widefield Findings in Proliferative Diabetic Retinopathy Treated with Intravitreal Aflibercept

Eyes with proliferative diabetic retinopathy (PDR) have been shown to improve in the leakage index and microaneurysm (MA) count after intravitreal aflibercept (IAI) treatment. The authors investigated these changes via automatic segmentation on ultra-widefield fluorescein angiography (UWFA). Forty s...

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Autores principales: Amy S. Babiuch, Charles C. Wykoff, Sari Yordi, Hannah Yu, Sunil K. Srivastava, Ming Hu, Thuy K. Le, Leina Lunasco, Jamie Reese, Muneeswar G. Nittala, SriniVas R. Sadda, Justis P. Ehlers
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spelling oai:doaj.org-article:723c4e4a16f54907b6ccb379a57b2c462021-11-25T18:07:24ZThe 2-Year Leakage Index and Quantitative Microaneurysm Results of the RECOVERY Study: Quantitative Ultra-Widefield Findings in Proliferative Diabetic Retinopathy Treated with Intravitreal Aflibercept10.3390/jpm111111262075-4426https://doaj.org/article/723c4e4a16f54907b6ccb379a57b2c462021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1126https://doaj.org/toc/2075-4426Eyes with proliferative diabetic retinopathy (PDR) have been shown to improve in the leakage index and microaneurysm (MA) count after intravitreal aflibercept (IAI) treatment. The authors investigated these changes via automatic segmentation on ultra-widefield fluorescein angiography (UWFA). Forty subjects with PDR were randomized to receive either 2 mg IAI every 4 weeks (Arm 1) or every 12 weeks (Arm 2) through Year 1. After Year 1, Arm 1 switched to quarterly IAI and Arm 2 to monthly IAI through Year 2. By Year 2, the Arm 1 leakage index decreased by 43% from Baseline (<i>p</i> = 0.03) but increased by 59% from Year 1 (<i>p</i> = 0.04). Arm 2 decreased by 61% from Baseline (<i>p</i> = 0.008) and by 31% from Year 1 (<i>p</i> = 0.12). Both cohorts exhibited a significant decline in MAs from Baseline to Year 2 (871 to 410; <i>p</i> < 0.001; 776 to 207; <i>p</i> < 0.001, respectively). Subjects with an improved leakage and MA count showed a more significant improvement in the Diabetic Retinopathy Severity Scale (DRSS) score. Moreover, central subfield thickness (CST) was positively associated with changes in the leakage index. In conclusion, the leakage index and MA counts significantly improved from Baseline following IAI treatment, and monthly injections provided a more rapid and sustained reduction in these parameters compared with quarterly injections.Amy S. BabiuchCharles C. WykoffSari YordiHannah YuSunil K. SrivastavaMing HuThuy K. LeLeina LunascoJamie ReeseMuneeswar G. NittalaSriniVas R. SaddaJustis P. EhlersMDPI AGarticleanti-vascular endothelial growth factordiabetic macular edemadiabetic retinopathyleakage indexmicroaneurysmsintravitreal afliberceptMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1126, p 1126 (2021)
institution DOAJ
collection DOAJ
language EN
topic anti-vascular endothelial growth factor
diabetic macular edema
diabetic retinopathy
leakage index
microaneurysms
intravitreal aflibercept
Medicine
R
spellingShingle anti-vascular endothelial growth factor
diabetic macular edema
diabetic retinopathy
leakage index
microaneurysms
intravitreal aflibercept
Medicine
R
Amy S. Babiuch
Charles C. Wykoff
Sari Yordi
Hannah Yu
Sunil K. Srivastava
Ming Hu
Thuy K. Le
Leina Lunasco
Jamie Reese
Muneeswar G. Nittala
SriniVas R. Sadda
Justis P. Ehlers
The 2-Year Leakage Index and Quantitative Microaneurysm Results of the RECOVERY Study: Quantitative Ultra-Widefield Findings in Proliferative Diabetic Retinopathy Treated with Intravitreal Aflibercept
description Eyes with proliferative diabetic retinopathy (PDR) have been shown to improve in the leakage index and microaneurysm (MA) count after intravitreal aflibercept (IAI) treatment. The authors investigated these changes via automatic segmentation on ultra-widefield fluorescein angiography (UWFA). Forty subjects with PDR were randomized to receive either 2 mg IAI every 4 weeks (Arm 1) or every 12 weeks (Arm 2) through Year 1. After Year 1, Arm 1 switched to quarterly IAI and Arm 2 to monthly IAI through Year 2. By Year 2, the Arm 1 leakage index decreased by 43% from Baseline (<i>p</i> = 0.03) but increased by 59% from Year 1 (<i>p</i> = 0.04). Arm 2 decreased by 61% from Baseline (<i>p</i> = 0.008) and by 31% from Year 1 (<i>p</i> = 0.12). Both cohorts exhibited a significant decline in MAs from Baseline to Year 2 (871 to 410; <i>p</i> < 0.001; 776 to 207; <i>p</i> < 0.001, respectively). Subjects with an improved leakage and MA count showed a more significant improvement in the Diabetic Retinopathy Severity Scale (DRSS) score. Moreover, central subfield thickness (CST) was positively associated with changes in the leakage index. In conclusion, the leakage index and MA counts significantly improved from Baseline following IAI treatment, and monthly injections provided a more rapid and sustained reduction in these parameters compared with quarterly injections.
format article
author Amy S. Babiuch
Charles C. Wykoff
Sari Yordi
Hannah Yu
Sunil K. Srivastava
Ming Hu
Thuy K. Le
Leina Lunasco
Jamie Reese
Muneeswar G. Nittala
SriniVas R. Sadda
Justis P. Ehlers
author_facet Amy S. Babiuch
Charles C. Wykoff
Sari Yordi
Hannah Yu
Sunil K. Srivastava
Ming Hu
Thuy K. Le
Leina Lunasco
Jamie Reese
Muneeswar G. Nittala
SriniVas R. Sadda
Justis P. Ehlers
author_sort Amy S. Babiuch
title The 2-Year Leakage Index and Quantitative Microaneurysm Results of the RECOVERY Study: Quantitative Ultra-Widefield Findings in Proliferative Diabetic Retinopathy Treated with Intravitreal Aflibercept
title_short The 2-Year Leakage Index and Quantitative Microaneurysm Results of the RECOVERY Study: Quantitative Ultra-Widefield Findings in Proliferative Diabetic Retinopathy Treated with Intravitreal Aflibercept
title_full The 2-Year Leakage Index and Quantitative Microaneurysm Results of the RECOVERY Study: Quantitative Ultra-Widefield Findings in Proliferative Diabetic Retinopathy Treated with Intravitreal Aflibercept
title_fullStr The 2-Year Leakage Index and Quantitative Microaneurysm Results of the RECOVERY Study: Quantitative Ultra-Widefield Findings in Proliferative Diabetic Retinopathy Treated with Intravitreal Aflibercept
title_full_unstemmed The 2-Year Leakage Index and Quantitative Microaneurysm Results of the RECOVERY Study: Quantitative Ultra-Widefield Findings in Proliferative Diabetic Retinopathy Treated with Intravitreal Aflibercept
title_sort 2-year leakage index and quantitative microaneurysm results of the recovery study: quantitative ultra-widefield findings in proliferative diabetic retinopathy treated with intravitreal aflibercept
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/723c4e4a16f54907b6ccb379a57b2c46
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