A spatio-temporal analysis of scrub typhus and murine typhus in Laos; implications from changing landscapes and climate.

<h4>Background</h4>Scrub typhus (ST) and murine typhus (MT) are common but poorly understood causes of fever in Laos. We examined the spatial and temporal distribution of ST and MT, with the intent of informing interventions to prevent and control both diseases.<h4>Methodology and...

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Autores principales:	Tamalee Roberts, Daniel M Parker, Philip L Bulterys, Sayaphet Rattanavong, Ivo Elliott, Koukeo Phommasone, Mayfong Mayxay, Vilada Chansamouth, Matthew T Robinson, Stuart D Blacksell, Paul N Newton
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/723c561424fa4c169c134e5e8730f412
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spelling	oai:doaj.org-article:723c561424fa4c169c134e5e8730f4122021-12-02T20:24:16ZA spatio-temporal analysis of scrub typhus and murine typhus in Laos; implications from changing landscapes and climate.1935-27271935-273510.1371/journal.pntd.0009685https://doaj.org/article/723c561424fa4c169c134e5e8730f4122021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009685https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>Scrub typhus (ST) and murine typhus (MT) are common but poorly understood causes of fever in Laos. We examined the spatial and temporal distribution of ST and MT, with the intent of informing interventions to prevent and control both diseases.<h4>Methodology and principle findings</h4>This study included samples submitted from 2003 to 2017 to Mahosot Hospital, Vientiane, for ST and MT investigation. Serum samples were tested using IgM rapid diagnostic tests. Patient demographic data along with meteorological and environmental data from Laos were analysed. Approximately 17% of patients were positive for either ST (1,337/8,150 patients tested) or MT (1,283/7,552 patients tested). While both diseases occurred in inhabitants from Vientiane Capital, from the univariable analysis MT was positively and ST negatively associated with residence in Vientiane Capital. ST was highly seasonal, with cases two times more likely to occur during the wet season months of July-September compared to the dry season whilst MT peaked in the dry season. Multivariable regression analysis linked ST incidence to fluctuations in relative humidity whereas MT was linked to variation in temperature. Patients with ST infection were more likely to come from villages with higher levels of surface flooding and vegetation in the 16 days leading up to diagnosis.<h4>Conclusions</h4>The data suggest that as cities expand, high risk areas for MT will also expand. With global heating and risks of attendant higher precipitation, these data suggest that the incidence and spatial distribution of both MT and ST will increase.Tamalee RobertsDaniel M ParkerPhilip L BulterysSayaphet RattanavongIvo ElliottKoukeo PhommasoneMayfong MayxayVilada ChansamouthMatthew T RobinsonStuart D BlacksellPaul N NewtonPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009685 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Tamalee Roberts Daniel M Parker Philip L Bulterys Sayaphet Rattanavong Ivo Elliott Koukeo Phommasone Mayfong Mayxay Vilada Chansamouth Matthew T Robinson Stuart D Blacksell Paul N Newton A spatio-temporal analysis of scrub typhus and murine typhus in Laos; implications from changing landscapes and climate.
description	<h4>Background</h4>Scrub typhus (ST) and murine typhus (MT) are common but poorly understood causes of fever in Laos. We examined the spatial and temporal distribution of ST and MT, with the intent of informing interventions to prevent and control both diseases.<h4>Methodology and principle findings</h4>This study included samples submitted from 2003 to 2017 to Mahosot Hospital, Vientiane, for ST and MT investigation. Serum samples were tested using IgM rapid diagnostic tests. Patient demographic data along with meteorological and environmental data from Laos were analysed. Approximately 17% of patients were positive for either ST (1,337/8,150 patients tested) or MT (1,283/7,552 patients tested). While both diseases occurred in inhabitants from Vientiane Capital, from the univariable analysis MT was positively and ST negatively associated with residence in Vientiane Capital. ST was highly seasonal, with cases two times more likely to occur during the wet season months of July-September compared to the dry season whilst MT peaked in the dry season. Multivariable regression analysis linked ST incidence to fluctuations in relative humidity whereas MT was linked to variation in temperature. Patients with ST infection were more likely to come from villages with higher levels of surface flooding and vegetation in the 16 days leading up to diagnosis.<h4>Conclusions</h4>The data suggest that as cities expand, high risk areas for MT will also expand. With global heating and risks of attendant higher precipitation, these data suggest that the incidence and spatial distribution of both MT and ST will increase.
format	article
author	Tamalee Roberts Daniel M Parker Philip L Bulterys Sayaphet Rattanavong Ivo Elliott Koukeo Phommasone Mayfong Mayxay Vilada Chansamouth Matthew T Robinson Stuart D Blacksell Paul N Newton
author_facet	Tamalee Roberts Daniel M Parker Philip L Bulterys Sayaphet Rattanavong Ivo Elliott Koukeo Phommasone Mayfong Mayxay Vilada Chansamouth Matthew T Robinson Stuart D Blacksell Paul N Newton
author_sort	Tamalee Roberts
title	A spatio-temporal analysis of scrub typhus and murine typhus in Laos; implications from changing landscapes and climate.
title_short	A spatio-temporal analysis of scrub typhus and murine typhus in Laos; implications from changing landscapes and climate.
title_full	A spatio-temporal analysis of scrub typhus and murine typhus in Laos; implications from changing landscapes and climate.
title_fullStr	A spatio-temporal analysis of scrub typhus and murine typhus in Laos; implications from changing landscapes and climate.
title_full_unstemmed	A spatio-temporal analysis of scrub typhus and murine typhus in Laos; implications from changing landscapes and climate.
title_sort	spatio-temporal analysis of scrub typhus and murine typhus in laos; implications from changing landscapes and climate.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/723c561424fa4c169c134e5e8730f412
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A spatio-temporal analysis of scrub typhus and murine typhus in Laos; implications from changing landscapes and climate.

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