Use of multiple metrics to assess antibiotic use in Italian children’s hospitals

Abstract Quantification of antibiotic utilization is an essential component of antibiotic stewardship programs. In this multicentric study, we used different metrics to evaluate inpatient antibiotic use in children. The study objectives were to describe point prevalence of antibiotic use by indicati...

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Autores principales:	Carmen D’Amore, Marta Luisa Ciofi degli Atti, Carla Zotti, Rosa Prato, Giuliano Guareschi, Raffaele Spiazzi, Gaetano Petitti, Maria Luisa Moro, Massimiliano Raponi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/723ea1c0b5464b1599d0794f99a04eac
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spelling	oai:doaj.org-article:723ea1c0b5464b1599d0794f99a04eac2021-12-02T14:26:55ZUse of multiple metrics to assess antibiotic use in Italian children’s hospitals10.1038/s41598-021-83026-12045-2322https://doaj.org/article/723ea1c0b5464b1599d0794f99a04eac2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83026-1https://doaj.org/toc/2045-2322Abstract Quantification of antibiotic utilization is an essential component of antibiotic stewardship programs. In this multicentric study, we used different metrics to evaluate inpatient antibiotic use in children. The study objectives were to describe point prevalence of antibiotic use by indication and patient characteristics, to evaluate DOTs, LOTs and PDDs, and to compare PDDs to DDDs, which assume average maintenance dose per day in adults. All children hospitalized on the days of the study were included. Trained personnel collected demographic and clinical data from patients’ clinical records. We recorded information about antibiotics administered on the date of data collection, and in the previous 30 days of hospitalization. Of 810 patients, 380 (46.9%; CI 95%: 43.4–50.4) received one or more antibiotics; prevalence of use was 27.0% for prophylaxis (219/810), and 20.7% (168/810) for treatment. Overall, 587 drugs were issued to the 380 patients receiving antibiotics (1.5 antibiotic per patient). When considering treatments, DOT and LOT per 100 patient-days were 30.5 and 19.1, respectively, resulting in a DOT/LOT ratio of 1.6. PDDs increased with age and approached DDDs only in children aged ≥ 10 years; the ratio between PDDs estimated in children aged ≥ 10 years and in 0–11 month-old infants ranged from 2 for sulfamethoxazole and trimethoprim, to 25 for meropenem. Our results confirm that DOT, LOT and PDD are better alternatives to DDD in children.Carmen D’AmoreMarta Luisa Ciofi degli AttiCarla ZottiRosa PratoGiuliano GuareschiRaffaele SpiazziGaetano PetittiMaria Luisa MoroMassimiliano RaponiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carmen D’Amore Marta Luisa Ciofi degli Atti Carla Zotti Rosa Prato Giuliano Guareschi Raffaele Spiazzi Gaetano Petitti Maria Luisa Moro Massimiliano Raponi Use of multiple metrics to assess antibiotic use in Italian children’s hospitals
description	Abstract Quantification of antibiotic utilization is an essential component of antibiotic stewardship programs. In this multicentric study, we used different metrics to evaluate inpatient antibiotic use in children. The study objectives were to describe point prevalence of antibiotic use by indication and patient characteristics, to evaluate DOTs, LOTs and PDDs, and to compare PDDs to DDDs, which assume average maintenance dose per day in adults. All children hospitalized on the days of the study were included. Trained personnel collected demographic and clinical data from patients’ clinical records. We recorded information about antibiotics administered on the date of data collection, and in the previous 30 days of hospitalization. Of 810 patients, 380 (46.9%; CI 95%: 43.4–50.4) received one or more antibiotics; prevalence of use was 27.0% for prophylaxis (219/810), and 20.7% (168/810) for treatment. Overall, 587 drugs were issued to the 380 patients receiving antibiotics (1.5 antibiotic per patient). When considering treatments, DOT and LOT per 100 patient-days were 30.5 and 19.1, respectively, resulting in a DOT/LOT ratio of 1.6. PDDs increased with age and approached DDDs only in children aged ≥ 10 years; the ratio between PDDs estimated in children aged ≥ 10 years and in 0–11 month-old infants ranged from 2 for sulfamethoxazole and trimethoprim, to 25 for meropenem. Our results confirm that DOT, LOT and PDD are better alternatives to DDD in children.
format	article
author	Carmen D’Amore Marta Luisa Ciofi degli Atti Carla Zotti Rosa Prato Giuliano Guareschi Raffaele Spiazzi Gaetano Petitti Maria Luisa Moro Massimiliano Raponi
author_facet	Carmen D’Amore Marta Luisa Ciofi degli Atti Carla Zotti Rosa Prato Giuliano Guareschi Raffaele Spiazzi Gaetano Petitti Maria Luisa Moro Massimiliano Raponi
author_sort	Carmen D’Amore
title	Use of multiple metrics to assess antibiotic use in Italian children’s hospitals
title_short	Use of multiple metrics to assess antibiotic use in Italian children’s hospitals
title_full	Use of multiple metrics to assess antibiotic use in Italian children’s hospitals
title_fullStr	Use of multiple metrics to assess antibiotic use in Italian children’s hospitals
title_full_unstemmed	Use of multiple metrics to assess antibiotic use in Italian children’s hospitals
title_sort	use of multiple metrics to assess antibiotic use in italian children’s hospitals
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/723ea1c0b5464b1599d0794f99a04eac
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_version_	1718391317961113600

Use of multiple metrics to assess antibiotic use in Italian children’s hospitals

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