The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging

Muscle regeneration depends on self-renewal of muscle stem cells but how this is regulated on aging is unclear. Here, the authors identify Slug as regulating p16 Ink4a in quiescent muscle stem cells, and when Slug expression reduces in aged stem cells, p16Ink4a accumulates, causing regenerative defe...

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Autores principales: Pei Zhu, Chunping Zhang, Yongxing Gao, Furen Wu, Yalu Zhou, Wen-Shu Wu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/723f96fddfe440c2b28aee7a57cb3f10
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Sumario:Muscle regeneration depends on self-renewal of muscle stem cells but how this is regulated on aging is unclear. Here, the authors identify Slug as regulating p16 Ink4a in quiescent muscle stem cells, and when Slug expression reduces in aged stem cells, p16Ink4a accumulates, causing regenerative defects.