The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging

Muscle regeneration depends on self-renewal of muscle stem cells but how this is regulated on aging is unclear. Here, the authors identify Slug as regulating p16 Ink4a in quiescent muscle stem cells, and when Slug expression reduces in aged stem cells, p16Ink4a accumulates, causing regenerative defe...

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Autores principales:	Pei Zhu, Chunping Zhang, Yongxing Gao, Furen Wu, Yalu Zhou, Wen-Shu Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/723f96fddfe440c2b28aee7a57cb3f10
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spelling	oai:doaj.org-article:723f96fddfe440c2b28aee7a57cb3f102021-12-02T14:40:20ZThe transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging10.1038/s41467-019-10479-42041-1723https://doaj.org/article/723f96fddfe440c2b28aee7a57cb3f102019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10479-4https://doaj.org/toc/2041-1723Muscle regeneration depends on self-renewal of muscle stem cells but how this is regulated on aging is unclear. Here, the authors identify Slug as regulating p16 Ink4a in quiescent muscle stem cells, and when Slug expression reduces in aged stem cells, p16Ink4a accumulates, causing regenerative defects.Pei ZhuChunping ZhangYongxing GaoFuren WuYalu ZhouWen-Shu WuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pei Zhu Chunping Zhang Yongxing Gao Furen Wu Yalu Zhou Wen-Shu Wu The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging
description	Muscle regeneration depends on self-renewal of muscle stem cells but how this is regulated on aging is unclear. Here, the authors identify Slug as regulating p16 Ink4a in quiescent muscle stem cells, and when Slug expression reduces in aged stem cells, p16Ink4a accumulates, causing regenerative defects.
format	article
author	Pei Zhu Chunping Zhang Yongxing Gao Furen Wu Yalu Zhou Wen-Shu Wu
author_facet	Pei Zhu Chunping Zhang Yongxing Gao Furen Wu Yalu Zhou Wen-Shu Wu
author_sort	Pei Zhu
title	The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging
title_short	The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging
title_full	The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging
title_fullStr	The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging
title_full_unstemmed	The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging
title_sort	transcription factor slug represses p16ink4a and regulates murine muscle stem cell aging
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/723f96fddfe440c2b28aee7a57cb3f10
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The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging

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