The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging
Muscle regeneration depends on self-renewal of muscle stem cells but how this is regulated on aging is unclear. Here, the authors identify Slug as regulating p16 Ink4a in quiescent muscle stem cells, and when Slug expression reduces in aged stem cells, p16Ink4a accumulates, causing regenerative defe...
Guardado en:
Autores principales: | Pei Zhu, Chunping Zhang, Yongxing Gao, Furen Wu, Yalu Zhou, Wen-Shu Wu |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
|
Materias: | |
Acceso en línea: | https://doaj.org/article/723f96fddfe440c2b28aee7a57cb3f10 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Human Papillomavirus 16 (HPV16) E2 Repression of TWIST1 Transcription Is a Potential Mediator of HPV16 Cancer Outcomes
por: Christian T. Fontan, et al.
Publicado: (2020) -
Aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila.
por: Kun Wu, et al.
Publicado: (2021) -
Human Papillomavirus 16 E6 and E7 Synergistically Repress Innate Immune Gene Transcription
por: Claire D. James, et al.
Publicado: (2020) -
Radionuclide, magnetic resonance and computed tomography imaging in European round back slugs (Arionidae) and leopard slugs (Limacidae)
por: Nicola Beindorff, et al.
Publicado: (2021) -
The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer.
por: Archana Dhasarathy, et al.
Publicado: (2011)