Microbial contribution to the caloric restriction-triggered regulation of the intestinal levels of glutathione transferases, taurine, and bile acid

Recently we showed that caloric restriction (CR) triggers an increase in the levels of free taurine, taurine-conjugated bile acids (BA), and other taurine conjugates in intestinal mucosa while decreasing glutathione (GSH) levels in wild-type male mice. In the current project, we decided to investiga...

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Autores principales:	András Gregor, Marc Pignitter, Slave Trajanoski, Sandra Auernigg-Haselmaier, Veronika Somoza, Jürgen König, Kalina Duszka
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	caloric restriction microbiota bile acids taurine glutathione intestine Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/72436faee41d4e39a28adffc709bc685
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spelling	oai:doaj.org-article:72436faee41d4e39a28adffc709bc6852021-11-04T15:00:42ZMicrobial contribution to the caloric restriction-triggered regulation of the intestinal levels of glutathione transferases, taurine, and bile acid1949-09761949-098410.1080/19490976.2021.1992236https://doaj.org/article/72436faee41d4e39a28adffc709bc6852021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/19490976.2021.1992236https://doaj.org/toc/1949-0976https://doaj.org/toc/1949-0984Recently we showed that caloric restriction (CR) triggers an increase in the levels of free taurine, taurine-conjugated bile acids (BA), and other taurine conjugates in intestinal mucosa while decreasing glutathione (GSH) levels in wild-type male mice. In the current project, we decided to investigate whether the microbiota is involved in the response to CR by depleting gut bacteria. The antibiotics treatment diminished CR-specific increase in the levels of free taurine and its conjugates as well as upregulated expression and activity of GSH transferases (GST) in the intestinal mucosa. Further, it diminished a CR-related increase in BAs levels in the liver, plasma, and intestinal mucosa. Transplant of microbiota from CR mice to ad libitum fed mice triggered CR-like changes in MGST1 expression, levels of taurine and taurine conjugates in the mucosa of the ileum. We show for the first time, that microbiota contributes to the intestinal response to CR-triggered changes in BA, taurine, and GST levels.András GregorMarc PignitterSlave TrajanoskiSandra Auernigg-HaselmaierVeronika SomozaJürgen KönigKalina DuszkaTaylor & Francis Grouparticlecaloric restrictionmicrobiotabile acidstaurineglutathioneintestineDiseases of the digestive system. GastroenterologyRC799-869ENGut Microbes, Vol 13, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	caloric restriction microbiota bile acids taurine glutathione intestine Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	caloric restriction microbiota bile acids taurine glutathione intestine Diseases of the digestive system. Gastroenterology RC799-869 András Gregor Marc Pignitter Slave Trajanoski Sandra Auernigg-Haselmaier Veronika Somoza Jürgen König Kalina Duszka Microbial contribution to the caloric restriction-triggered regulation of the intestinal levels of glutathione transferases, taurine, and bile acid
description	Recently we showed that caloric restriction (CR) triggers an increase in the levels of free taurine, taurine-conjugated bile acids (BA), and other taurine conjugates in intestinal mucosa while decreasing glutathione (GSH) levels in wild-type male mice. In the current project, we decided to investigate whether the microbiota is involved in the response to CR by depleting gut bacteria. The antibiotics treatment diminished CR-specific increase in the levels of free taurine and its conjugates as well as upregulated expression and activity of GSH transferases (GST) in the intestinal mucosa. Further, it diminished a CR-related increase in BAs levels in the liver, plasma, and intestinal mucosa. Transplant of microbiota from CR mice to ad libitum fed mice triggered CR-like changes in MGST1 expression, levels of taurine and taurine conjugates in the mucosa of the ileum. We show for the first time, that microbiota contributes to the intestinal response to CR-triggered changes in BA, taurine, and GST levels.
format	article
author	András Gregor Marc Pignitter Slave Trajanoski Sandra Auernigg-Haselmaier Veronika Somoza Jürgen König Kalina Duszka
author_facet	András Gregor Marc Pignitter Slave Trajanoski Sandra Auernigg-Haselmaier Veronika Somoza Jürgen König Kalina Duszka
author_sort	András Gregor
title	Microbial contribution to the caloric restriction-triggered regulation of the intestinal levels of glutathione transferases, taurine, and bile acid
title_short	Microbial contribution to the caloric restriction-triggered regulation of the intestinal levels of glutathione transferases, taurine, and bile acid
title_full	Microbial contribution to the caloric restriction-triggered regulation of the intestinal levels of glutathione transferases, taurine, and bile acid
title_fullStr	Microbial contribution to the caloric restriction-triggered regulation of the intestinal levels of glutathione transferases, taurine, and bile acid
title_full_unstemmed	Microbial contribution to the caloric restriction-triggered regulation of the intestinal levels of glutathione transferases, taurine, and bile acid
title_sort	microbial contribution to the caloric restriction-triggered regulation of the intestinal levels of glutathione transferases, taurine, and bile acid
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/72436faee41d4e39a28adffc709bc685
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Microbial contribution to the caloric restriction-triggered regulation of the intestinal levels of glutathione transferases, taurine, and bile acid

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