Anti-aging and antioxidant of four traditional malaysian plants using simplex centroid mixture design approach

Aging is a naturally biological process with adverse effects. The continuous accumulation of reactive oxygen species (ROS) trigger cellular and tissue damage by activating several aging enzymes. The antioxidant properties of traditional medicinal plants used by Jakun aborigine’s community are a prom...

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Autores principales:	Yazan Ranneh, Mohd Fadzelly Abu Bakar, Nur Amalina Ismail, Faridah Kormin, Maryati Mohamed, Abdah Md Akim, Azizul Isha
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Anti-aging Herbal Formulation Women Antioxidant Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/72469b786f6244d5b1d5d928d9b24066
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spelling	oai:doaj.org-article:72469b786f6244d5b1d5d928d9b240662021-11-20T04:56:23ZAnti-aging and antioxidant of four traditional malaysian plants using simplex centroid mixture design approach1319-562X10.1016/j.sjbs.2021.07.048https://doaj.org/article/72469b786f6244d5b1d5d928d9b240662021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1319562X21006306https://doaj.org/toc/1319-562XAging is a naturally biological process with adverse effects. The continuous accumulation of reactive oxygen species (ROS) trigger cellular and tissue damage by activating several aging enzymes. The antioxidant properties of traditional medicinal plants used by Jakun aborigine’s community are a promising approach to alleviate aging process and prevent Alzheimer. The aim of the current investigation was to optimize a novel anti-aging formulation from traditional plants (Cnestis palala stem, Urceola micrantha stem, Marantodes pumilum stem and Microporus xanthopus fruiting bodies) using simplex centroid mixture design (SCMD). After selecting the optimal formulations based on desirability function of antioxidant activity (DPPḢ, ABTṠ+ and FRAP), they were further examined against the activity of aging-related-enzymes (collagenase, tyrosinase, acetyl- and butyrylcholinesterase). The single extracts of C. palala, U. micrantha and the binary mixture of C. palala and U. micrantha were the optimal formulations with high antioxidant activities. Single extract of U. micrantha showed the highest inhibition towards matrix metalloproteinase-1 (49.44 ± 4.11 %), while C. palala water extract showed highest inhibitions towards tyrosinase (14.06 ± 0.31%), acetylcholinesterase (32.92 ± 2.13%) and butyrylcholinesterase (34.89 ± 2.84%) enzymes. The single extracts of C. palala and U. micrantha displayed better activity as compared to the binary mixture formulation. In conclusion, these findings could be a baseline for further exploration of novel anti-aging agents from natural resources.Yazan RannehMohd Fadzelly Abu BakarNur Amalina IsmailFaridah KorminMaryati MohamedAbdah Md AkimAzizul IshaElsevierarticleAnti-agingHerbalFormulationWomenAntioxidantBiology (General)QH301-705.5ENSaudi Journal of Biological Sciences, Vol 28, Iss 12, Pp 6711-6720 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Anti-aging Herbal Formulation Women Antioxidant Biology (General) QH301-705.5
spellingShingle	Anti-aging Herbal Formulation Women Antioxidant Biology (General) QH301-705.5 Yazan Ranneh Mohd Fadzelly Abu Bakar Nur Amalina Ismail Faridah Kormin Maryati Mohamed Abdah Md Akim Azizul Isha Anti-aging and antioxidant of four traditional malaysian plants using simplex centroid mixture design approach
description	Aging is a naturally biological process with adverse effects. The continuous accumulation of reactive oxygen species (ROS) trigger cellular and tissue damage by activating several aging enzymes. The antioxidant properties of traditional medicinal plants used by Jakun aborigine’s community are a promising approach to alleviate aging process and prevent Alzheimer. The aim of the current investigation was to optimize a novel anti-aging formulation from traditional plants (Cnestis palala stem, Urceola micrantha stem, Marantodes pumilum stem and Microporus xanthopus fruiting bodies) using simplex centroid mixture design (SCMD). After selecting the optimal formulations based on desirability function of antioxidant activity (DPPḢ, ABTṠ+ and FRAP), they were further examined against the activity of aging-related-enzymes (collagenase, tyrosinase, acetyl- and butyrylcholinesterase). The single extracts of C. palala, U. micrantha and the binary mixture of C. palala and U. micrantha were the optimal formulations with high antioxidant activities. Single extract of U. micrantha showed the highest inhibition towards matrix metalloproteinase-1 (49.44 ± 4.11 %), while C. palala water extract showed highest inhibitions towards tyrosinase (14.06 ± 0.31%), acetylcholinesterase (32.92 ± 2.13%) and butyrylcholinesterase (34.89 ± 2.84%) enzymes. The single extracts of C. palala and U. micrantha displayed better activity as compared to the binary mixture formulation. In conclusion, these findings could be a baseline for further exploration of novel anti-aging agents from natural resources.
format	article
author	Yazan Ranneh Mohd Fadzelly Abu Bakar Nur Amalina Ismail Faridah Kormin Maryati Mohamed Abdah Md Akim Azizul Isha
author_facet	Yazan Ranneh Mohd Fadzelly Abu Bakar Nur Amalina Ismail Faridah Kormin Maryati Mohamed Abdah Md Akim Azizul Isha
author_sort	Yazan Ranneh
title	Anti-aging and antioxidant of four traditional malaysian plants using simplex centroid mixture design approach
title_short	Anti-aging and antioxidant of four traditional malaysian plants using simplex centroid mixture design approach
title_full	Anti-aging and antioxidant of four traditional malaysian plants using simplex centroid mixture design approach
title_fullStr	Anti-aging and antioxidant of four traditional malaysian plants using simplex centroid mixture design approach
title_full_unstemmed	Anti-aging and antioxidant of four traditional malaysian plants using simplex centroid mixture design approach
title_sort	anti-aging and antioxidant of four traditional malaysian plants using simplex centroid mixture design approach
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/72469b786f6244d5b1d5d928d9b24066
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Anti-aging and antioxidant of four traditional malaysian plants using simplex centroid mixture design approach

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