A [6+4]-cycloaddition adduct is the biosynthetic intermediate in streptoseomycin biosynthesis

Streptoseomycin is a potent antibiotic that contains a pentacyclic 5/14/10/6/6 ring system. Here, the authors report the enzymatic and non-enzymatic steps of the downstream modification of streptoseomycin biosynthesis and show a [6 + 4]-cycloaddition adduct as an unexpected biosynthetic intermediate...

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Autores principales:	Kai Biao Wang, Wen Wang, Bo Zhang, Xin Wang, Yu Chen, Hong Jie Zhu, Yong Liang, Ren Xiang Tan, Hui Ming Ge
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7246c7166a5548fca61b1e86049ac423
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spelling	oai:doaj.org-article:7246c7166a5548fca61b1e86049ac4232021-12-02T14:21:15ZA [6+4]-cycloaddition adduct is the biosynthetic intermediate in streptoseomycin biosynthesis10.1038/s41467-021-22395-72041-1723https://doaj.org/article/7246c7166a5548fca61b1e86049ac4232021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22395-7https://doaj.org/toc/2041-1723Streptoseomycin is a potent antibiotic that contains a pentacyclic 5/14/10/6/6 ring system. Here, the authors report the enzymatic and non-enzymatic steps of the downstream modification of streptoseomycin biosynthesis and show a [6 + 4]-cycloaddition adduct as an unexpected biosynthetic intermediate.Kai Biao WangWen WangBo ZhangXin WangYu ChenHong Jie ZhuYong LiangRen Xiang TanHui Ming GeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kai Biao Wang Wen Wang Bo Zhang Xin Wang Yu Chen Hong Jie Zhu Yong Liang Ren Xiang Tan Hui Ming Ge A [6+4]-cycloaddition adduct is the biosynthetic intermediate in streptoseomycin biosynthesis
description	Streptoseomycin is a potent antibiotic that contains a pentacyclic 5/14/10/6/6 ring system. Here, the authors report the enzymatic and non-enzymatic steps of the downstream modification of streptoseomycin biosynthesis and show a [6 + 4]-cycloaddition adduct as an unexpected biosynthetic intermediate.
format	article
author	Kai Biao Wang Wen Wang Bo Zhang Xin Wang Yu Chen Hong Jie Zhu Yong Liang Ren Xiang Tan Hui Ming Ge
author_facet	Kai Biao Wang Wen Wang Bo Zhang Xin Wang Yu Chen Hong Jie Zhu Yong Liang Ren Xiang Tan Hui Ming Ge
author_sort	Kai Biao Wang
title	A [6+4]-cycloaddition adduct is the biosynthetic intermediate in streptoseomycin biosynthesis
title_short	A [6+4]-cycloaddition adduct is the biosynthetic intermediate in streptoseomycin biosynthesis
title_full	A [6+4]-cycloaddition adduct is the biosynthetic intermediate in streptoseomycin biosynthesis
title_fullStr	A [6+4]-cycloaddition adduct is the biosynthetic intermediate in streptoseomycin biosynthesis
title_full_unstemmed	A [6+4]-cycloaddition adduct is the biosynthetic intermediate in streptoseomycin biosynthesis
title_sort	[6+4]-cycloaddition adduct is the biosynthetic intermediate in streptoseomycin biosynthesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7246c7166a5548fca61b1e86049ac423
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A [6+4]-cycloaddition adduct is the biosynthetic intermediate in streptoseomycin biosynthesis

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