Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation

Telomerase activity correlates with distinct cell states, but can be challenging to quantify. Here the authors quantify telomerase activity across a range of biological samples using the expression of 13 genes, and show it correlates with cancer cell proliferation and stemness.

Guardado en:

Detalles Bibliográficos
Autores principales:	Nighat Noureen, Shaofang Wu, Yingli Lv, Juechen Yang, W. K. Alfred Yung, Jonathan Gelfond, Xiaojing Wang, Dimpy Koul, Andrew Ludlow, Siyuan Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/724dd20ce70c4007ae4d8becee60fbbd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:724dd20ce70c4007ae4d8becee60fbbd
record_format	dspace
spelling	oai:doaj.org-article:724dd20ce70c4007ae4d8becee60fbbd2021-12-02T11:56:18ZIntegrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation10.1038/s41467-020-20474-92041-1723https://doaj.org/article/724dd20ce70c4007ae4d8becee60fbbd2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20474-9https://doaj.org/toc/2041-1723Telomerase activity correlates with distinct cell states, but can be challenging to quantify. Here the authors quantify telomerase activity across a range of biological samples using the expression of 13 genes, and show it correlates with cancer cell proliferation and stemness.Nighat NoureenShaofang WuYingli LvJuechen YangW. K. Alfred YungJonathan GelfondXiaojing WangDimpy KoulAndrew LudlowSiyuan ZhengNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nighat Noureen Shaofang Wu Yingli Lv Juechen Yang W. K. Alfred Yung Jonathan Gelfond Xiaojing Wang Dimpy Koul Andrew Ludlow Siyuan Zheng Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation
description	Telomerase activity correlates with distinct cell states, but can be challenging to quantify. Here the authors quantify telomerase activity across a range of biological samples using the expression of 13 genes, and show it correlates with cancer cell proliferation and stemness.
format	article
author	Nighat Noureen Shaofang Wu Yingli Lv Juechen Yang W. K. Alfred Yung Jonathan Gelfond Xiaojing Wang Dimpy Koul Andrew Ludlow Siyuan Zheng
author_facet	Nighat Noureen Shaofang Wu Yingli Lv Juechen Yang W. K. Alfred Yung Jonathan Gelfond Xiaojing Wang Dimpy Koul Andrew Ludlow Siyuan Zheng
author_sort	Nighat Noureen
title	Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation
title_short	Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation
title_full	Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation
title_fullStr	Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation
title_full_unstemmed	Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation
title_sort	integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/724dd20ce70c4007ae4d8becee60fbbd
work_keys_str_mv	AT nighatnoureen integratedanalysisoftelomeraseenzymaticactivityunravelsanassociationwithcancerstemnessandproliferation AT shaofangwu integratedanalysisoftelomeraseenzymaticactivityunravelsanassociationwithcancerstemnessandproliferation AT yinglilv integratedanalysisoftelomeraseenzymaticactivityunravelsanassociationwithcancerstemnessandproliferation AT juechenyang integratedanalysisoftelomeraseenzymaticactivityunravelsanassociationwithcancerstemnessandproliferation AT wkalfredyung integratedanalysisoftelomeraseenzymaticactivityunravelsanassociationwithcancerstemnessandproliferation AT jonathangelfond integratedanalysisoftelomeraseenzymaticactivityunravelsanassociationwithcancerstemnessandproliferation AT xiaojingwang integratedanalysisoftelomeraseenzymaticactivityunravelsanassociationwithcancerstemnessandproliferation AT dimpykoul integratedanalysisoftelomeraseenzymaticactivityunravelsanassociationwithcancerstemnessandproliferation AT andrewludlow integratedanalysisoftelomeraseenzymaticactivityunravelsanassociationwithcancerstemnessandproliferation AT siyuanzheng integratedanalysisoftelomeraseenzymaticactivityunravelsanassociationwithcancerstemnessandproliferation
_version_	1718394812242067456

Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation

Ejemplares similares