Squamous Cell Carcinoma as a Complication of Long-Term Hydroxyurea Treatment

Hydroxyurea therapy is commonly used in the treatment of patients suffering from myeloproliferative diseases, such as polycythemia vera. It is supported by evidence that this type of therapy can generate mild skin lesions like leg ulcers, erythema, and hyperpigmentation. There are also some studies...

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Autores principales:	Miłosz Lewandowski, Paweł Łukowicz, Jerzy Jankau, Jan Romantowski, Wioletta Barańska-Rybak
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	squamous cell carcinoma hydroxyurea nonmelanoma skin cancer chemoprevention complication Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/724fd26635d44e19a5253a89de4d543a
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spelling	oai:doaj.org-article:724fd26635d44e19a5253a89de4d543a2021-12-02T12:40:22ZSquamous Cell Carcinoma as a Complication of Long-Term Hydroxyurea Treatment1662-656710.1159/000520542https://doaj.org/article/724fd26635d44e19a5253a89de4d543a2021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/520542https://doaj.org/toc/1662-6567Hydroxyurea therapy is commonly used in the treatment of patients suffering from myeloproliferative diseases, such as polycythemia vera. It is supported by evidence that this type of therapy can generate mild skin lesions like leg ulcers, erythema, and hyperpigmentation. There are also some studies that show an increased risk of development of nonmelanoma skin cancers. We report a 56-year-old man with a 13-year history of polycythemia vera, treated chronically with hydroxyurea. In April 2020, the patient presented a skin lesion on the forehead, skin horn on the left forearm, and hyperkeratosis on the rims of both ears. In the patient’s history, in October 2019, complete excision of the skin lesion in the central area of the forehead was performed. After 4 months, a new skin lesion appeared at the same area of the forehead, which in May 2020 after resection in the histopathological examination was diagnosed as recurrence of squamous cell carcinoma. The aim of the case is to draw the clinicians’ attention to the increased risk of squamous cell carcinoma and basal cell carcinoma in patients treated with hydroxyurea. Increased vigilance would make it possible to recognize them earlier, and thus potentially reduce the undesirable effects associated with the delayed radical treatment of these skin cancers. Randomized clinical trials assessing the potential benefits of oral retinoids for chemoprevention of nonmelanoma skin cancers in the hydroxyurea-treated population should also be considered.Miłosz LewandowskiPaweł ŁukowiczJerzy JankauJan RomantowskiWioletta Barańska-RybakKarger Publishersarticlesquamous cell carcinomahydroxyureanonmelanoma skin cancerchemopreventioncomplicationDermatologyRL1-803ENCase Reports in Dermatology, Vol 13, Iss 3, Pp 542-546 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	squamous cell carcinoma hydroxyurea nonmelanoma skin cancer chemoprevention complication Dermatology RL1-803
spellingShingle	squamous cell carcinoma hydroxyurea nonmelanoma skin cancer chemoprevention complication Dermatology RL1-803 Miłosz Lewandowski Paweł Łukowicz Jerzy Jankau Jan Romantowski Wioletta Barańska-Rybak Squamous Cell Carcinoma as a Complication of Long-Term Hydroxyurea Treatment
description	Hydroxyurea therapy is commonly used in the treatment of patients suffering from myeloproliferative diseases, such as polycythemia vera. It is supported by evidence that this type of therapy can generate mild skin lesions like leg ulcers, erythema, and hyperpigmentation. There are also some studies that show an increased risk of development of nonmelanoma skin cancers. We report a 56-year-old man with a 13-year history of polycythemia vera, treated chronically with hydroxyurea. In April 2020, the patient presented a skin lesion on the forehead, skin horn on the left forearm, and hyperkeratosis on the rims of both ears. In the patient’s history, in October 2019, complete excision of the skin lesion in the central area of the forehead was performed. After 4 months, a new skin lesion appeared at the same area of the forehead, which in May 2020 after resection in the histopathological examination was diagnosed as recurrence of squamous cell carcinoma. The aim of the case is to draw the clinicians’ attention to the increased risk of squamous cell carcinoma and basal cell carcinoma in patients treated with hydroxyurea. Increased vigilance would make it possible to recognize them earlier, and thus potentially reduce the undesirable effects associated with the delayed radical treatment of these skin cancers. Randomized clinical trials assessing the potential benefits of oral retinoids for chemoprevention of nonmelanoma skin cancers in the hydroxyurea-treated population should also be considered.
format	article
author	Miłosz Lewandowski Paweł Łukowicz Jerzy Jankau Jan Romantowski Wioletta Barańska-Rybak
author_facet	Miłosz Lewandowski Paweł Łukowicz Jerzy Jankau Jan Romantowski Wioletta Barańska-Rybak
author_sort	Miłosz Lewandowski
title	Squamous Cell Carcinoma as a Complication of Long-Term Hydroxyurea Treatment
title_short	Squamous Cell Carcinoma as a Complication of Long-Term Hydroxyurea Treatment
title_full	Squamous Cell Carcinoma as a Complication of Long-Term Hydroxyurea Treatment
title_fullStr	Squamous Cell Carcinoma as a Complication of Long-Term Hydroxyurea Treatment
title_full_unstemmed	Squamous Cell Carcinoma as a Complication of Long-Term Hydroxyurea Treatment
title_sort	squamous cell carcinoma as a complication of long-term hydroxyurea treatment
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/724fd26635d44e19a5253a89de4d543a
work_keys_str_mv	AT miłoszlewandowski squamouscellcarcinomaasacomplicationoflongtermhydroxyureatreatment AT pawełłukowicz squamouscellcarcinomaasacomplicationoflongtermhydroxyureatreatment AT jerzyjankau squamouscellcarcinomaasacomplicationoflongtermhydroxyureatreatment AT janromantowski squamouscellcarcinomaasacomplicationoflongtermhydroxyureatreatment AT wiolettabaranskarybak squamouscellcarcinomaasacomplicationoflongtermhydroxyureatreatment
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Squamous Cell Carcinoma as a Complication of Long-Term Hydroxyurea Treatment

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