Helicobacter pylori eradication improves motor fluctuations in advanced Parkinson's disease patients: A prospective cohort study (HP-PD trial).

<h4>Background</h4>Helicobacter pylori (HP) is a bacterium associated with many gastrointestinal (GI) diseases and has shown a high prevalence in Parkinson's disease (PD). As HP-associated GI dysfunction could affect L-dopa (levodopa) absorption, HP eradication might improve the cli...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Praween Lolekha, Thanakarn Sriphanom, Ratha-Korn Vilaichone
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7253bbd2f4804341af3ce59629042993
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7253bbd2f4804341af3ce59629042993
record_format	dspace
spelling	oai:doaj.org-article:7253bbd2f4804341af3ce596290429932021-11-25T06:19:22ZHelicobacter pylori eradication improves motor fluctuations in advanced Parkinson's disease patients: A prospective cohort study (HP-PD trial).1932-620310.1371/journal.pone.0251042https://doaj.org/article/7253bbd2f4804341af3ce596290429932021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251042https://doaj.org/toc/1932-6203<h4>Background</h4>Helicobacter pylori (HP) is a bacterium associated with many gastrointestinal (GI) diseases and has shown a high prevalence in Parkinson's disease (PD). As HP-associated GI dysfunction could affect L-dopa (levodopa) absorption, HP eradication might improve the clinical response and decrease motor fluctuations.<h4>Methods</h4>A prospective cohort study was conducted on the clinical symptoms of PD patients with motor fluctuations. The 13C-urea breath test was used to diagnose a current HP infection. All patients with HP infection received a 2-week regimen of triple therapy. The changes in the Unified Parkinson's Disease Rating Scale (UPDRS) motor score, L-dopa onset time, wearing-off symptoms, mean daily on-off time, GI symptom scores, and quality of life score were measured at baseline and at a 6-week follow-up.<h4>Results</h4>A total of 163 PD patients were assessed, of whom 40 were enrolled. Fifty-five percent of the enrolled patients (22/40) had a current HP infection, whereas HP eradication was identified in 17 of 22 (77.3%) patients who received eradication therapy. Patients with HP eradication showed a significant decrease in daily 'off' time (4.0 vs. 4.7 h, p = 0.040) and an increase in daily 'on' time (11.8 vs. 10.9 h, p = 0.009). Total wearing-off score (4.4 vs. 6.0, p = 0.001) and the GI symptom score (8.1 vs. 12.8, p = 0.007) were significantly improved. There was no significant improvement in L-dopa onset time, UPDRS motor score, or quality of life score.<h4>Conclusions</h4>HP eradication leads to significant clinical improvement in the symptoms of PD. Eradication of HP not only increases the total daily 'on' time but also decreases wearing-off symptoms and improves GI symptoms.Praween LolekhaThanakarn SriphanomRatha-Korn VilaichonePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251042 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Praween Lolekha Thanakarn Sriphanom Ratha-Korn Vilaichone Helicobacter pylori eradication improves motor fluctuations in advanced Parkinson's disease patients: A prospective cohort study (HP-PD trial).
description	<h4>Background</h4>Helicobacter pylori (HP) is a bacterium associated with many gastrointestinal (GI) diseases and has shown a high prevalence in Parkinson's disease (PD). As HP-associated GI dysfunction could affect L-dopa (levodopa) absorption, HP eradication might improve the clinical response and decrease motor fluctuations.<h4>Methods</h4>A prospective cohort study was conducted on the clinical symptoms of PD patients with motor fluctuations. The 13C-urea breath test was used to diagnose a current HP infection. All patients with HP infection received a 2-week regimen of triple therapy. The changes in the Unified Parkinson's Disease Rating Scale (UPDRS) motor score, L-dopa onset time, wearing-off symptoms, mean daily on-off time, GI symptom scores, and quality of life score were measured at baseline and at a 6-week follow-up.<h4>Results</h4>A total of 163 PD patients were assessed, of whom 40 were enrolled. Fifty-five percent of the enrolled patients (22/40) had a current HP infection, whereas HP eradication was identified in 17 of 22 (77.3%) patients who received eradication therapy. Patients with HP eradication showed a significant decrease in daily 'off' time (4.0 vs. 4.7 h, p = 0.040) and an increase in daily 'on' time (11.8 vs. 10.9 h, p = 0.009). Total wearing-off score (4.4 vs. 6.0, p = 0.001) and the GI symptom score (8.1 vs. 12.8, p = 0.007) were significantly improved. There was no significant improvement in L-dopa onset time, UPDRS motor score, or quality of life score.<h4>Conclusions</h4>HP eradication leads to significant clinical improvement in the symptoms of PD. Eradication of HP not only increases the total daily 'on' time but also decreases wearing-off symptoms and improves GI symptoms.
format	article
author	Praween Lolekha Thanakarn Sriphanom Ratha-Korn Vilaichone
author_facet	Praween Lolekha Thanakarn Sriphanom Ratha-Korn Vilaichone
author_sort	Praween Lolekha
title	Helicobacter pylori eradication improves motor fluctuations in advanced Parkinson's disease patients: A prospective cohort study (HP-PD trial).
title_short	Helicobacter pylori eradication improves motor fluctuations in advanced Parkinson's disease patients: A prospective cohort study (HP-PD trial).
title_full	Helicobacter pylori eradication improves motor fluctuations in advanced Parkinson's disease patients: A prospective cohort study (HP-PD trial).
title_fullStr	Helicobacter pylori eradication improves motor fluctuations in advanced Parkinson's disease patients: A prospective cohort study (HP-PD trial).
title_full_unstemmed	Helicobacter pylori eradication improves motor fluctuations in advanced Parkinson's disease patients: A prospective cohort study (HP-PD trial).
title_sort	helicobacter pylori eradication improves motor fluctuations in advanced parkinson's disease patients: a prospective cohort study (hp-pd trial).
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/7253bbd2f4804341af3ce59629042993
work_keys_str_mv	AT praweenlolekha helicobacterpylorieradicationimprovesmotorfluctuationsinadvancedparkinsonsdiseasepatientsaprospectivecohortstudyhppdtrial AT thanakarnsriphanom helicobacterpylorieradicationimprovesmotorfluctuationsinadvancedparkinsonsdiseasepatientsaprospectivecohortstudyhppdtrial AT rathakornvilaichone helicobacterpylorieradicationimprovesmotorfluctuationsinadvancedparkinsonsdiseasepatientsaprospectivecohortstudyhppdtrial
_version_	1718413870039564288

Helicobacter pylori eradication improves motor fluctuations in advanced Parkinson's disease patients: A prospective cohort study (HP-PD trial).

Ejemplares similares