Activation of the Host Immune Response in Hyphantria cunea (Drury) (Lepidoptera: Noctuidae) Induced by Serratia marcescens Bizio

Host–pathogen interactions are essential to our understanding of biological pesticides. Hyphantria cunea (Drury) is an important forest pest worldwide. The immune mechanism of the interaction between H. cunea and Serratia marcescens Bizio (SM1...

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Autores principales:	Zhiqiang Wang, Kai Feng, Fang Tang, Meng Xu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Hyphantria cunea</i> (Drury) <i>Serratia marcescens</i> Bizio insect–bacteria interaction antimicrobial peptides melanization cellular immunity Science Q
Acceso en línea:	https://doaj.org/article/72591dfd3f6c4e3f980e1c559da6e270
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spelling	oai:doaj.org-article:72591dfd3f6c4e3f980e1c559da6e2702021-11-25T17:59:16ZActivation of the Host Immune Response in <i>Hyphantria cunea</i> (Drury) (Lepidoptera: Noctuidae) Induced by <i>Serratia marcescens</i> Bizio10.3390/insects121109832075-4450https://doaj.org/article/72591dfd3f6c4e3f980e1c559da6e2702021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4450/12/11/983https://doaj.org/toc/2075-4450Host–pathogen interactions are essential to our understanding of biological pesticides. <i>Hyphantria cunea</i> (Drury) is an important forest pest worldwide. The immune mechanism of the interaction between <i>H. cunea</i> and <i>Serratia marcescens</i> Bizio (SM1) is unclear. First, transcriptome sequencing and quantitative real-time PCR (qRT-PCR) analysis described the <i>H. cunea</i> immune response to SM1. A total of 234 immune-related differentially expressed genes (DEGs) were found. Many immune regulatory genes in three classical pathways were found. Antimicrobial peptides, including attacin B, cecropin A, gloverin, lebocin and diapausin, are involved in defending against SM1 challenge, and are mainly produced by Toll and immune deficiency (IMD) pathways. Some melanization genes were changed in <i>H. cunea</i>, which suggested that <i>H. cunea</i> melanization was activated by SM1. Furthermore, phagocytosis, autophagolysosome and apoptosis pathways in cellular immunity were activated in <i>H. cunea</i> against SM1. Finally, the expression patterns of 10 immune genes were analyzed systematically by qRT-PCR, and most of the genes were upregulated compared to the control. Our studies provide useful information about the immune response of <i>H. cunea</i> under the stress of SM1, which is important to understand how SM1 affects the immune system of <i>H. cunea</i> and provides new ideas to control <i>H. cunea</i> by using SM1.Zhiqiang WangKai FengFang TangMeng XuMDPI AGarticle<i>Hyphantria cunea</i> (Drury)<i>Serratia marcescens</i> Bizioinsect–bacteria interactionantimicrobial peptidesmelanizationcellular immunityScienceQENInsects, Vol 12, Iss 983, p 983 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Hyphantria cunea</i> (Drury) <i>Serratia marcescens</i> Bizio insect–bacteria interaction antimicrobial peptides melanization cellular immunity Science Q
spellingShingle	<i>Hyphantria cunea</i> (Drury) <i>Serratia marcescens</i> Bizio insect–bacteria interaction antimicrobial peptides melanization cellular immunity Science Q Zhiqiang Wang Kai Feng Fang Tang Meng Xu Activation of the Host Immune Response in <i>Hyphantria cunea</i> (Drury) (Lepidoptera: Noctuidae) Induced by <i>Serratia marcescens</i> Bizio
description	Host–pathogen interactions are essential to our understanding of biological pesticides. <i>Hyphantria cunea</i> (Drury) is an important forest pest worldwide. The immune mechanism of the interaction between <i>H. cunea</i> and <i>Serratia marcescens</i> Bizio (SM1) is unclear. First, transcriptome sequencing and quantitative real-time PCR (qRT-PCR) analysis described the <i>H. cunea</i> immune response to SM1. A total of 234 immune-related differentially expressed genes (DEGs) were found. Many immune regulatory genes in three classical pathways were found. Antimicrobial peptides, including attacin B, cecropin A, gloverin, lebocin and diapausin, are involved in defending against SM1 challenge, and are mainly produced by Toll and immune deficiency (IMD) pathways. Some melanization genes were changed in <i>H. cunea</i>, which suggested that <i>H. cunea</i> melanization was activated by SM1. Furthermore, phagocytosis, autophagolysosome and apoptosis pathways in cellular immunity were activated in <i>H. cunea</i> against SM1. Finally, the expression patterns of 10 immune genes were analyzed systematically by qRT-PCR, and most of the genes were upregulated compared to the control. Our studies provide useful information about the immune response of <i>H. cunea</i> under the stress of SM1, which is important to understand how SM1 affects the immune system of <i>H. cunea</i> and provides new ideas to control <i>H. cunea</i> by using SM1.
format	article
author	Zhiqiang Wang Kai Feng Fang Tang Meng Xu
author_facet	Zhiqiang Wang Kai Feng Fang Tang Meng Xu
author_sort	Zhiqiang Wang
title	Activation of the Host Immune Response in <i>Hyphantria cunea</i> (Drury) (Lepidoptera: Noctuidae) Induced by <i>Serratia marcescens</i> Bizio
title_short	Activation of the Host Immune Response in <i>Hyphantria cunea</i> (Drury) (Lepidoptera: Noctuidae) Induced by <i>Serratia marcescens</i> Bizio
title_full	Activation of the Host Immune Response in <i>Hyphantria cunea</i> (Drury) (Lepidoptera: Noctuidae) Induced by <i>Serratia marcescens</i> Bizio
title_fullStr	Activation of the Host Immune Response in <i>Hyphantria cunea</i> (Drury) (Lepidoptera: Noctuidae) Induced by <i>Serratia marcescens</i> Bizio
title_full_unstemmed	Activation of the Host Immune Response in <i>Hyphantria cunea</i> (Drury) (Lepidoptera: Noctuidae) Induced by <i>Serratia marcescens</i> Bizio
title_sort	activation of the host immune response in <i>hyphantria cunea</i> (drury) (lepidoptera: noctuidae) induced by <i>serratia marcescens</i> bizio
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/72591dfd3f6c4e3f980e1c559da6e270
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_version_	1718411750741639168

Activation of the Host Immune Response in <i>Hyphantria cunea</i> (Drury) (Lepidoptera: Noctuidae) Induced by <i>Serratia marcescens</i> Bizio

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