Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm

Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm

Tocilizumab has been used to treat the excessive inflammatory responses in COVID-19 patients. Here, the authors use single-cell RNA sequencing results from two severe COIVD-19 patients to provide high-dimensional immune profiling data, and to implicate potential cellular and molecular insights for t...

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Autores principales: Chuang Guo, Bin Li, Huan Ma, Xiaofang Wang, Pengfei Cai, Qiaoni Yu, Lin Zhu, Liying Jin, Chen Jiang, Jingwen Fang, Qian Liu, Dandan Zong, Wen Zhang, Yichen Lu, Kun Li, Xuyuan Gao, Binqing Fu, Lianxin Liu, Xiaoling Ma, Jianping Weng, Haiming Wei, Tengchuan Jin, Jun Lin, Kun Qu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/725c63210c6543e5bbfeb15fc0ba1839
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spelling oai:doaj.org-article:725c63210c6543e5bbfeb15fc0ba18392021-12-02T17:06:12ZSingle-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm10.1038/s41467-020-17834-w2041-1723https://doaj.org/article/725c63210c6543e5bbfeb15fc0ba18392020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17834-whttps://doaj.org/toc/2041-1723Tocilizumab has been used to treat the excessive inflammatory responses in COVID-19 patients. Here, the authors use single-cell RNA sequencing results from two severe COIVD-19 patients to provide high-dimensional immune profiling data, and to implicate potential cellular and molecular insights for the therapeutic effects of tocilizumab.Chuang GuoBin LiHuan MaXiaofang WangPengfei CaiQiaoni YuLin ZhuLiying JinChen JiangJingwen FangQian LiuDandan ZongWen ZhangYichen LuKun LiXuyuan GaoBinqing FuLianxin LiuXiaoling MaJianping WengHaiming WeiTengchuan JinJun LinKun QuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chuang Guo
Bin Li
Huan Ma
Xiaofang Wang
Pengfei Cai
Qiaoni Yu
Lin Zhu
Liying Jin
Chen Jiang
Jingwen Fang
Qian Liu
Dandan Zong
Wen Zhang
Yichen Lu
Kun Li
Xuyuan Gao
Binqing Fu
Lianxin Liu
Xiaoling Ma
Jianping Weng
Haiming Wei
Tengchuan Jin
Jun Lin
Kun Qu
Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm
description Tocilizumab has been used to treat the excessive inflammatory responses in COVID-19 patients. Here, the authors use single-cell RNA sequencing results from two severe COIVD-19 patients to provide high-dimensional immune profiling data, and to implicate potential cellular and molecular insights for the therapeutic effects of tocilizumab.
format article
author Chuang Guo
Bin Li
Huan Ma
Xiaofang Wang
Pengfei Cai
Qiaoni Yu
Lin Zhu
Liying Jin
Chen Jiang
Jingwen Fang
Qian Liu
Dandan Zong
Wen Zhang
Yichen Lu
Kun Li
Xuyuan Gao
Binqing Fu
Lianxin Liu
Xiaoling Ma
Jianping Weng
Haiming Wei
Tengchuan Jin
Jun Lin
Kun Qu
author_facet Chuang Guo
Bin Li
Huan Ma
Xiaofang Wang
Pengfei Cai
Qiaoni Yu
Lin Zhu
Liying Jin
Chen Jiang
Jingwen Fang
Qian Liu
Dandan Zong
Wen Zhang
Yichen Lu
Kun Li
Xuyuan Gao
Binqing Fu
Lianxin Liu
Xiaoling Ma
Jianping Weng
Haiming Wei
Tengchuan Jin
Jun Lin
Kun Qu
author_sort Chuang Guo
title Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm
title_short Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm
title_full Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm
title_fullStr Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm
title_full_unstemmed Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm
title_sort single-cell analysis of two severe covid-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/725c63210c6543e5bbfeb15fc0ba1839
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