The effects of aging on sleep parameters in a healthy, melatonin-competent mouse model

Jiffin K Paulose,1 Chanung Wang,1,2 Bruce F O’Hara,1 Vincent M Cassone11Department of Biology, University of Kentucky, Lexington, KY 40515, USA; 2Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USABackground: Sleep disturbances are common maladies as...

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Autores principales:	Paulose JK, Wang C, O'Hara BF, Cassone VM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Sleep Circadian rhythms Aging Piezoelectric CBA/J Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/725d1a73bf6f450680d74e589d085041
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spelling	oai:doaj.org-article:725d1a73bf6f450680d74e589d0850412021-12-02T09:26:54ZThe effects of aging on sleep parameters in a healthy, melatonin-competent mouse model1179-1608https://doaj.org/article/725d1a73bf6f450680d74e589d0850412019-08-01T00:00:00Zhttps://www.dovepress.com/the-effects-of-aging-on-sleep-parameters-in-a-healthy-melatonin-compet-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Jiffin K Paulose,1 Chanung Wang,1,2 Bruce F O’Hara,1 Vincent M Cassone11Department of Biology, University of Kentucky, Lexington, KY 40515, USA; 2Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USABackground: Sleep disturbances are common maladies associated with human age. Sleep duration is decreased, sleep fragmentation is increased, and the timing of sleep onset and sleep offset is earlier. These disturbances have been associated with several neurodegenerative diseases. Mouse models for human sleep disturbances can be powerful due to the accessibility to neuroscientific and genetic approaches, but these are hampered by the fact that most mouse models employed in sleep research have spontaneous mutations in the biosynthetic pathway(s) regulating the rhythmic production of the pineal hormone melatonin, which has been implicated in human sleep.Purpose and method: The present study employed a non-invasive piezoelectric measure of sleep wake cycles in young, middle-aged and old CBA mice, a strain capable of melatonin biosynthesis, to investigate naturally-occurring changes in sleep and circadian parameters as the result of aging.Results: The results indicate that young mice sleep less than do middle-aged or aged mice, especially during the night, while the timing of activity onset and acrophase is delayed in aged mice compared to younger mice.Conclusion: These data point to an effect of aging on the quality and timing of sleep in these mice but also that there are fundamental differences between control of sleep in humans and in laboratory mice.Keywords: sleep, circadian rhythms, aging, piezoelectric, CBA/JPaulose JKWang CO'Hara BFCassone VMDove Medical PressarticleSleepCircadian rhythmsAgingPiezoelectricCBA/JPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 11, Pp 113-121 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sleep Circadian rhythms Aging Piezoelectric CBA/J Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	Sleep Circadian rhythms Aging Piezoelectric CBA/J Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Paulose JK Wang C O'Hara BF Cassone VM The effects of aging on sleep parameters in a healthy, melatonin-competent mouse model
description	Jiffin K Paulose,1 Chanung Wang,1,2 Bruce F O’Hara,1 Vincent M Cassone11Department of Biology, University of Kentucky, Lexington, KY 40515, USA; 2Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USABackground: Sleep disturbances are common maladies associated with human age. Sleep duration is decreased, sleep fragmentation is increased, and the timing of sleep onset and sleep offset is earlier. These disturbances have been associated with several neurodegenerative diseases. Mouse models for human sleep disturbances can be powerful due to the accessibility to neuroscientific and genetic approaches, but these are hampered by the fact that most mouse models employed in sleep research have spontaneous mutations in the biosynthetic pathway(s) regulating the rhythmic production of the pineal hormone melatonin, which has been implicated in human sleep.Purpose and method: The present study employed a non-invasive piezoelectric measure of sleep wake cycles in young, middle-aged and old CBA mice, a strain capable of melatonin biosynthesis, to investigate naturally-occurring changes in sleep and circadian parameters as the result of aging.Results: The results indicate that young mice sleep less than do middle-aged or aged mice, especially during the night, while the timing of activity onset and acrophase is delayed in aged mice compared to younger mice.Conclusion: These data point to an effect of aging on the quality and timing of sleep in these mice but also that there are fundamental differences between control of sleep in humans and in laboratory mice.Keywords: sleep, circadian rhythms, aging, piezoelectric, CBA/J
format	article
author	Paulose JK Wang C O'Hara BF Cassone VM
author_facet	Paulose JK Wang C O'Hara BF Cassone VM
author_sort	Paulose JK
title	The effects of aging on sleep parameters in a healthy, melatonin-competent mouse model
title_short	The effects of aging on sleep parameters in a healthy, melatonin-competent mouse model
title_full	The effects of aging on sleep parameters in a healthy, melatonin-competent mouse model
title_fullStr	The effects of aging on sleep parameters in a healthy, melatonin-competent mouse model
title_full_unstemmed	The effects of aging on sleep parameters in a healthy, melatonin-competent mouse model
title_sort	effects of aging on sleep parameters in a healthy, melatonin-competent mouse model
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/725d1a73bf6f450680d74e589d085041
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The effects of aging on sleep parameters in a healthy, melatonin-competent mouse model

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