Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation

EZH2-mediated methylatation of histone 3 is essential for immune regulation. Here, the authors show that EZH2 inhibitors attenuate experimental colitis in mice by promoting the development of myeloid-derived suppressor cells, and delay the onset of colitis-associated cancer.

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Autores principales:	Jie Zhou, Shuo Huang, Zhongyu Wang, Jiani Huang, Liang Xu, Xuefeng Tang, Yisong Y. Wan, Qi-jing Li, Alistair L. J. Symonds, Haixia Long, Bo Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/725ed1506054442e94b8485433a49e9f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:725ed1506054442e94b8485433a49e9f2021-12-02T16:57:24ZTargeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation10.1038/s41467-019-10176-22041-1723https://doaj.org/article/725ed1506054442e94b8485433a49e9f2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10176-2https://doaj.org/toc/2041-1723EZH2-mediated methylatation of histone 3 is essential for immune regulation. Here, the authors show that EZH2 inhibitors attenuate experimental colitis in mice by promoting the development of myeloid-derived suppressor cells, and delay the onset of colitis-associated cancer.Jie ZhouShuo HuangZhongyu WangJiani HuangLiang XuXuefeng TangYisong Y. WanQi-jing LiAlistair L. J. SymondsHaixia LongBo ZhuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jie Zhou Shuo Huang Zhongyu Wang Jiani Huang Liang Xu Xuefeng Tang Yisong Y. Wan Qi-jing Li Alistair L. J. Symonds Haixia Long Bo Zhu Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation
description	EZH2-mediated methylatation of histone 3 is essential for immune regulation. Here, the authors show that EZH2 inhibitors attenuate experimental colitis in mice by promoting the development of myeloid-derived suppressor cells, and delay the onset of colitis-associated cancer.
format	article
author	Jie Zhou Shuo Huang Zhongyu Wang Jiani Huang Liang Xu Xuefeng Tang Yisong Y. Wan Qi-jing Li Alistair L. J. Symonds Haixia Long Bo Zhu
author_facet	Jie Zhou Shuo Huang Zhongyu Wang Jiani Huang Liang Xu Xuefeng Tang Yisong Y. Wan Qi-jing Li Alistair L. J. Symonds Haixia Long Bo Zhu
author_sort	Jie Zhou
title	Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation
title_short	Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation
title_full	Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation
title_fullStr	Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation
title_full_unstemmed	Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation
title_sort	targeting ezh2 histone methyltransferase activity alleviates experimental intestinal inflammation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/725ed1506054442e94b8485433a49e9f
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Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation

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