microRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression

Functional miRNAs derived from the 5p or 3p arm of some miRNA duplexes have opposite roles in cancer progression. Here, the authors show that oncogenic miR-574-5p has greater preference in aggressive gastric cancer as compared with miR-574-3p and this arm preference is partly dependent on complement...

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Autores principales:	Zhengyi Zhang, Jingnan Pi, Dongling Zou, Xiaoshuang Wang, Jiayue Xu, Shan Yu, Ting Zhang, Feng Li, Xianxie Zhang, Hualu Zhao, Fang Wang, Dong Wang, Yanni Ma, Jia Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7260606bc40d4b239a3f39b04abc4d57
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spelling	oai:doaj.org-article:7260606bc40d4b239a3f39b04abc4d572021-12-02T15:35:48ZmicroRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression10.1038/s41467-019-12292-52041-1723https://doaj.org/article/7260606bc40d4b239a3f39b04abc4d572019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12292-5https://doaj.org/toc/2041-1723Functional miRNAs derived from the 5p or 3p arm of some miRNA duplexes have opposite roles in cancer progression. Here, the authors show that oncogenic miR-574-5p has greater preference in aggressive gastric cancer as compared with miR-574-3p and this arm preference is partly dependent on complementary targets mediated miRNA decay.Zhengyi ZhangJingnan PiDongling ZouXiaoshuang WangJiayue XuShan YuTing ZhangFeng LiXianxie ZhangHualu ZhaoFang WangDong WangYanni MaJia YuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhengyi Zhang Jingnan Pi Dongling Zou Xiaoshuang Wang Jiayue Xu Shan Yu Ting Zhang Feng Li Xianxie Zhang Hualu Zhao Fang Wang Dong Wang Yanni Ma Jia Yu microRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression
description	Functional miRNAs derived from the 5p or 3p arm of some miRNA duplexes have opposite roles in cancer progression. Here, the authors show that oncogenic miR-574-5p has greater preference in aggressive gastric cancer as compared with miR-574-3p and this arm preference is partly dependent on complementary targets mediated miRNA decay.
format	article
author	Zhengyi Zhang Jingnan Pi Dongling Zou Xiaoshuang Wang Jiayue Xu Shan Yu Ting Zhang Feng Li Xianxie Zhang Hualu Zhao Fang Wang Dong Wang Yanni Ma Jia Yu
author_facet	Zhengyi Zhang Jingnan Pi Dongling Zou Xiaoshuang Wang Jiayue Xu Shan Yu Ting Zhang Feng Li Xianxie Zhang Hualu Zhao Fang Wang Dong Wang Yanni Ma Jia Yu
author_sort	Zhengyi Zhang
title	microRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression
title_short	microRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression
title_full	microRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression
title_fullStr	microRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression
title_full_unstemmed	microRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression
title_sort	microrna arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7260606bc40d4b239a3f39b04abc4d57
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microRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression

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