Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

Chronic lymphocytic leukaemia has a hereditary component, much of which remains to be identified. Here, the authors perform a genome-wide association study and find new risk loci for the disease, which are associated with genes involved in immune function.

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Autores principales:	Philip J. Law, Sonja I. Berndt, Helen E. Speedy, Nicola J. Camp, Georgina P. Sava, Christine F. Skibola, Amy Holroyd, Vijai Joseph, Nicola J. Sunter, Alexandra Nieters, Silvia Bea, Alain Monnereau, David Martin-Garcia, Lynn R. Goldin, Guillem Clot, Lauren R. Teras, Inés Quintela, Brenda M. Birmann, Sandrine Jayne, Wendy Cozen, Aneela Majid, Karin E. Smedby, Qing Lan, Claire Dearden, Angela R. Brooks-Wilson, Andrew G. Hall, Mark P. Purdue, Tryfonia Mainou-Fowler, Claire M. Vajdic, Graham H. Jackson, Pierluigi Cocco, Helen Marr, Yawei Zhang, Tongzhang Zheng, Graham G. Giles, Charles Lawrence, Timothy G. Call, Mark Liebow, Mads Melbye, Bengt Glimelius, Larry Mansouri, Martha Glenn, Karen Curtin, W Ryan Diver, Brian K. Link, Lucia Conde, Paige M. Bracci, Elizabeth A. Holly, Rebecca D. Jackson, Lesley F. Tinker, Yolanda Benavente, Paolo Boffetta, Paul Brennan, Marc Maynadie, James McKay, Demetrius Albanes, Stephanie Weinstein, Zhaoming Wang, Neil E. Caporaso, Lindsay M. Morton, Richard K. Severson, Elio Riboli, Paolo Vineis, Roel C. H. Vermeulen, Melissa C. Southey, Roger L. Milne, Jacqueline Clavel, Sabine Topka, John J. Spinelli, Peter Kraft, Maria Grazia Ennas, Geoffrey Summerfield, Giovanni M. Ferri, Robert J. Harris, Lucia Miligi, Andrew R. Pettitt, Kari E. North, David J. Allsup, Joseph F. Fraumeni, James R. Bailey, Kenneth Offit, Guy Pratt, Henrik Hjalgrim, Chris Pepper, Stephen J. Chanock, Chris Fegan, Richard Rosenquist, Silvia de Sanjose, Angel Carracedo, Martin J. S. Dyer, Daniel Catovsky, Elias Campo, James R. Cerhan, James M. Allan, Nathanial Rothman, Richard Houlston, Susan Slager
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7260f008ee8e4abd981c7eed2433bb15
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spelling	oai:doaj.org-article:7260f008ee8e4abd981c7eed2433bb152021-12-02T14:42:10ZGenome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia10.1038/ncomms141752041-1723https://doaj.org/article/7260f008ee8e4abd981c7eed2433bb152017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14175https://doaj.org/toc/2041-1723Chronic lymphocytic leukaemia has a hereditary component, much of which remains to be identified. Here, the authors perform a genome-wide association study and find new risk loci for the disease, which are associated with genes involved in immune function.Philip J. LawSonja I. BerndtHelen E. SpeedyNicola J. CampGeorgina P. SavaChristine F. SkibolaAmy HolroydVijai JosephNicola J. SunterAlexandra NietersSilvia BeaAlain MonnereauDavid Martin-GarciaLynn R. GoldinGuillem ClotLauren R. TerasInés QuintelaBrenda M. BirmannSandrine JayneWendy CozenAneela MajidKarin E. SmedbyQing LanClaire DeardenAngela R. Brooks-WilsonAndrew G. HallMark P. PurdueTryfonia Mainou-FowlerClaire M. VajdicGraham H. JacksonPierluigi CoccoHelen MarrYawei ZhangTongzhang ZhengGraham G. GilesCharles LawrenceTimothy G. CallMark LiebowMads MelbyeBengt GlimeliusLarry MansouriMartha GlennKaren CurtinW Ryan DiverBrian K. LinkLucia CondePaige M. BracciElizabeth A. HollyRebecca D. JacksonLesley F. TinkerYolanda BenaventePaolo BoffettaPaul BrennanMarc MaynadieJames McKayDemetrius AlbanesStephanie WeinsteinZhaoming WangNeil E. CaporasoLindsay M. MortonRichard K. SeversonElio RiboliPaolo VineisRoel C. H. VermeulenMelissa C. SoutheyRoger L. MilneJacqueline ClavelSabine TopkaJohn J. SpinelliPeter KraftMaria Grazia EnnasGeoffrey SummerfieldGiovanni M. FerriRobert J. HarrisLucia MiligiAndrew R. PettittKari E. NorthDavid J. AllsupJoseph F. FraumeniJames R. BaileyKenneth OffitGuy PrattHenrik HjalgrimChris PepperStephen J. ChanockChris FeganRichard RosenquistSilvia de SanjoseAngel CarracedoMartin J. S. DyerDaniel CatovskyElias CampoJames R. CerhanJames M. AllanNathanial RothmanRichard HoulstonSusan SlagerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Philip J. Law Sonja I. Berndt Helen E. Speedy Nicola J. Camp Georgina P. Sava Christine F. Skibola Amy Holroyd Vijai Joseph Nicola J. Sunter Alexandra Nieters Silvia Bea Alain Monnereau David Martin-Garcia Lynn R. Goldin Guillem Clot Lauren R. Teras Inés Quintela Brenda M. Birmann Sandrine Jayne Wendy Cozen Aneela Majid Karin E. Smedby Qing Lan Claire Dearden Angela R. Brooks-Wilson Andrew G. Hall Mark P. Purdue Tryfonia Mainou-Fowler Claire M. Vajdic Graham H. Jackson Pierluigi Cocco Helen Marr Yawei Zhang Tongzhang Zheng Graham G. Giles Charles Lawrence Timothy G. Call Mark Liebow Mads Melbye Bengt Glimelius Larry Mansouri Martha Glenn Karen Curtin W Ryan Diver Brian K. Link Lucia Conde Paige M. Bracci Elizabeth A. Holly Rebecca D. Jackson Lesley F. Tinker Yolanda Benavente Paolo Boffetta Paul Brennan Marc Maynadie James McKay Demetrius Albanes Stephanie Weinstein Zhaoming Wang Neil E. Caporaso Lindsay M. Morton Richard K. Severson Elio Riboli Paolo Vineis Roel C. H. Vermeulen Melissa C. Southey Roger L. Milne Jacqueline Clavel Sabine Topka John J. Spinelli Peter Kraft Maria Grazia Ennas Geoffrey Summerfield Giovanni M. Ferri Robert J. Harris Lucia Miligi Andrew R. Pettitt Kari E. North David J. Allsup Joseph F. Fraumeni James R. Bailey Kenneth Offit Guy Pratt Henrik Hjalgrim Chris Pepper Stephen J. Chanock Chris Fegan Richard Rosenquist Silvia de Sanjose Angel Carracedo Martin J. S. Dyer Daniel Catovsky Elias Campo James R. Cerhan James M. Allan Nathanial Rothman Richard Houlston Susan Slager Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia
description	Chronic lymphocytic leukaemia has a hereditary component, much of which remains to be identified. Here, the authors perform a genome-wide association study and find new risk loci for the disease, which are associated with genes involved in immune function.
format	article
author	Philip J. Law Sonja I. Berndt Helen E. Speedy Nicola J. Camp Georgina P. Sava Christine F. Skibola Amy Holroyd Vijai Joseph Nicola J. Sunter Alexandra Nieters Silvia Bea Alain Monnereau David Martin-Garcia Lynn R. Goldin Guillem Clot Lauren R. Teras Inés Quintela Brenda M. Birmann Sandrine Jayne Wendy Cozen Aneela Majid Karin E. Smedby Qing Lan Claire Dearden Angela R. Brooks-Wilson Andrew G. Hall Mark P. Purdue Tryfonia Mainou-Fowler Claire M. Vajdic Graham H. Jackson Pierluigi Cocco Helen Marr Yawei Zhang Tongzhang Zheng Graham G. Giles Charles Lawrence Timothy G. Call Mark Liebow Mads Melbye Bengt Glimelius Larry Mansouri Martha Glenn Karen Curtin W Ryan Diver Brian K. Link Lucia Conde Paige M. Bracci Elizabeth A. Holly Rebecca D. Jackson Lesley F. Tinker Yolanda Benavente Paolo Boffetta Paul Brennan Marc Maynadie James McKay Demetrius Albanes Stephanie Weinstein Zhaoming Wang Neil E. Caporaso Lindsay M. Morton Richard K. Severson Elio Riboli Paolo Vineis Roel C. H. Vermeulen Melissa C. Southey Roger L. Milne Jacqueline Clavel Sabine Topka John J. Spinelli Peter Kraft Maria Grazia Ennas Geoffrey Summerfield Giovanni M. Ferri Robert J. Harris Lucia Miligi Andrew R. Pettitt Kari E. North David J. Allsup Joseph F. Fraumeni James R. Bailey Kenneth Offit Guy Pratt Henrik Hjalgrim Chris Pepper Stephen J. Chanock Chris Fegan Richard Rosenquist Silvia de Sanjose Angel Carracedo Martin J. S. Dyer Daniel Catovsky Elias Campo James R. Cerhan James M. Allan Nathanial Rothman Richard Houlston Susan Slager
author_facet	Philip J. Law Sonja I. Berndt Helen E. Speedy Nicola J. Camp Georgina P. Sava Christine F. Skibola Amy Holroyd Vijai Joseph Nicola J. Sunter Alexandra Nieters Silvia Bea Alain Monnereau David Martin-Garcia Lynn R. Goldin Guillem Clot Lauren R. Teras Inés Quintela Brenda M. Birmann Sandrine Jayne Wendy Cozen Aneela Majid Karin E. Smedby Qing Lan Claire Dearden Angela R. Brooks-Wilson Andrew G. Hall Mark P. Purdue Tryfonia Mainou-Fowler Claire M. Vajdic Graham H. Jackson Pierluigi Cocco Helen Marr Yawei Zhang Tongzhang Zheng Graham G. Giles Charles Lawrence Timothy G. Call Mark Liebow Mads Melbye Bengt Glimelius Larry Mansouri Martha Glenn Karen Curtin W Ryan Diver Brian K. Link Lucia Conde Paige M. Bracci Elizabeth A. Holly Rebecca D. Jackson Lesley F. Tinker Yolanda Benavente Paolo Boffetta Paul Brennan Marc Maynadie James McKay Demetrius Albanes Stephanie Weinstein Zhaoming Wang Neil E. Caporaso Lindsay M. Morton Richard K. Severson Elio Riboli Paolo Vineis Roel C. H. Vermeulen Melissa C. Southey Roger L. Milne Jacqueline Clavel Sabine Topka John J. Spinelli Peter Kraft Maria Grazia Ennas Geoffrey Summerfield Giovanni M. Ferri Robert J. Harris Lucia Miligi Andrew R. Pettitt Kari E. North David J. Allsup Joseph F. Fraumeni James R. Bailey Kenneth Offit Guy Pratt Henrik Hjalgrim Chris Pepper Stephen J. Chanock Chris Fegan Richard Rosenquist Silvia de Sanjose Angel Carracedo Martin J. S. Dyer Daniel Catovsky Elias Campo James R. Cerhan James M. Allan Nathanial Rothman Richard Houlston Susan Slager
author_sort	Philip J. Law
title	Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia
title_short	Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia
title_full	Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia
title_fullStr	Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia
title_full_unstemmed	Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia
title_sort	genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7260f008ee8e4abd981c7eed2433bb15
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Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

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