Pathogenesis of Alzheimer′s disease
Russell H SwerdlowDepartment of Neurology, University of Virginia School of Medicine, Charlottesville, VA, USAAbstract: Alzheimer’s disease (AD) is incredibly common. Increasing longevity ensures its prevalence will rise even further. Ongoing efforts to understand AD pathogenesis reveal nu...
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2007
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| Acceso en línea: | https://doaj.org/article/7260fbb5f0bb47af8c6fc4d692fbcb38 |
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| Sumario: | Russell H SwerdlowDepartment of Neurology, University of Virginia School of Medicine, Charlottesville, VA, USAAbstract: Alzheimer’s disease (AD) is incredibly common. Increasing longevity ensures its prevalence will rise even further. Ongoing efforts to understand AD pathogenesis reveal numerous tantalizing leads. Formulating a comprehensive AD pathogenesis theory capable of incorporating these disparate leads, though, has proven difficult. This review discusses current attempts to formulate a comprehensive AD pathogenesis theory. In doing so, it focuses on clinical and molecular relationships between AD and aging. A better understanding of these relationships could inform and impact future development of AD-directed treatment strategies.Keywords: Alzheimer’s disease, aging, amyloid, cascade, mitochondria |
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