Pathogenesis of Alzheimer′s disease
Russell H SwerdlowDepartment of Neurology, University of Virginia School of Medicine, Charlottesville, VA, USAAbstract: Alzheimer’s disease (AD) is incredibly common. Increasing longevity ensures its prevalence will rise even further. Ongoing efforts to understand AD pathogenesis reveal nu...
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Dove Medical Press
2007
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oai:doaj.org-article:7260fbb5f0bb47af8c6fc4d692fbcb382021-12-02T00:30:23ZPathogenesis of Alzheimer′s disease1178-1998https://doaj.org/article/7260fbb5f0bb47af8c6fc4d692fbcb382007-10-01T00:00:00Zhttps://www.dovepress.com/pathogenesis-of-alzheimerprimes-disease-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Russell H SwerdlowDepartment of Neurology, University of Virginia School of Medicine, Charlottesville, VA, USAAbstract: Alzheimer’s disease (AD) is incredibly common. Increasing longevity ensures its prevalence will rise even further. Ongoing efforts to understand AD pathogenesis reveal numerous tantalizing leads. Formulating a comprehensive AD pathogenesis theory capable of incorporating these disparate leads, though, has proven difficult. This review discusses current attempts to formulate a comprehensive AD pathogenesis theory. In doing so, it focuses on clinical and molecular relationships between AD and aging. A better understanding of these relationships could inform and impact future development of AD-directed treatment strategies.Keywords: Alzheimer’s disease, aging, amyloid, cascade, mitochondriaRussell H SwerdlowDove Medical PressarticleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 2, Pp 347-359 (2007) |
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DOAJ |
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EN |
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Geriatrics RC952-954.6 |
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Geriatrics RC952-954.6 Russell H Swerdlow Pathogenesis of Alzheimer′s disease |
| description |
Russell H SwerdlowDepartment of Neurology, University of Virginia School of Medicine, Charlottesville, VA, USAAbstract: Alzheimer’s disease (AD) is incredibly common. Increasing longevity ensures its prevalence will rise even further. Ongoing efforts to understand AD pathogenesis reveal numerous tantalizing leads. Formulating a comprehensive AD pathogenesis theory capable of incorporating these disparate leads, though, has proven difficult. This review discusses current attempts to formulate a comprehensive AD pathogenesis theory. In doing so, it focuses on clinical and molecular relationships between AD and aging. A better understanding of these relationships could inform and impact future development of AD-directed treatment strategies.Keywords: Alzheimer’s disease, aging, amyloid, cascade, mitochondria |
| format |
article |
| author |
Russell H Swerdlow |
| author_facet |
Russell H Swerdlow |
| author_sort |
Russell H Swerdlow |
| title |
Pathogenesis of Alzheimer′s disease |
| title_short |
Pathogenesis of Alzheimer′s disease |
| title_full |
Pathogenesis of Alzheimer′s disease |
| title_fullStr |
Pathogenesis of Alzheimer′s disease |
| title_full_unstemmed |
Pathogenesis of Alzheimer′s disease |
| title_sort |
pathogenesis of alzheimer′s disease |
| publisher |
Dove Medical Press |
| publishDate |
2007 |
| url |
https://doaj.org/article/7260fbb5f0bb47af8c6fc4d692fbcb38 |
| work_keys_str_mv |
AT russellhswerdlow pathogenesisofalzheimerprimesdisease |
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1718403682334146560 |